ArticleInvestigative ophthalmology & visual science2016
Sebum/Meibum Surface Film Interactions and Phase Transitional Differences.
Article in Investigative ophthalmology & visual science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 40 citations in OpenAlex.
- Meibum Lipid Saturation Related to Dry Eye, Age, and Sex Using Nuclear Magnetic Resonance Spectroscopy.Investigative ophthalmology & visual science · 2026Article
- Biophysical Interactions of Silicon Quantum Dots With Human Tears and Dry Eye Drops: A Langmuir Trough Study.Translational vision science & technology · 2026Article
- Comparative Characterization of Human Meibomian Glands, Free Sebaceous Glands, and Hair-Associated Sebaceous Glands Based on Biomarkers, Analysis of Secretion Composition, and Gland Morphology.International journal of molecular sciences · 2024Article
- Relationship Between Human Meibum Lipid Composition and the Severity of Meibomian Gland Dysfunction: A Spectroscopic Analysis.Investigative ophthalmology & visual science · 2023Article
- Integrated multi-omics and machine learning approach reveals lipid metabolic biomarkers and signaling in age-related meibomian gland dysfunction.Computational and structural biotechnology journal · 2023Article
- The Riddle of Cetuximab-Related Skin Toxicity:Cancers · 2022Article
- Dermatochalasis Aggravates Meibomian Gland Dysfunction Related Dry Eyes.Journal of clinical medicine · 2022Article
- Surface Chemistry Study of the Interactions of Sesame Oil with Meibomian Films.Molecules (Basel, Switzerland) · 2022Article
- Meibum sphingolipid composition is altered in individuals with meibomian gland dysfunction-a side by side comparison of Meibum and Tear Sphingolipids.The ocular surface · 2022Article
- A spectroscopic approach to measuring meibum lipid composition and conformation in donors with Sjӧgren's syndrome.Experimental eye research · 2021Article
- A spectroscopic study of the composition and conformation of cholesteryl and wax esters purified from meibum.Chemistry and physics of lipids · 2021Article
- Hyaluronic acid-lipid binding.BMC chemistry · 2021Article
- Meibum Lipid Composition and Conformation in Parkinsonism.EC ophthalmology · 2021Article
- Meibum lipid hydrocarbon chain branching and rheology after hematopoietic stem cell transplantation.Biochemistry and biophysics reports · 2020Article
- Concentration dependent cholesteryl-ester and wax-ester structural relationships and meibomian gland dysfunction.Biochemistry and biophysics reports · 2020Article
- Changes in meibum composition following plaque bachytherapy for choroidal melanoma.BMJ open ophthalmology · 2020Article
- Article
- Structural Differences in Meibum From Donors After Hematopoietic Stem Cell Transplantations.Cornea · 2019Article
- Lipid Saturation and the Rheology of Human Tear Lipids.International journal of molecular sciences · 2019Article
- Human Meibum Cholesteryl and Wax Ester Variability With Age, Sex, and Meibomian Gland Dysfunction.Investigative ophthalmology & visual science · 2019Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
purposeSebum may contribute to the composition of the tear film lipid layer naturally or as a contaminant artifact from collection. The aims of this study were to determine: if sebum changes the rheology of meibum surface films; if the resonance near 5.2 ppm in the 1H-NMR spectra of sebum is due to squalene (SQ); and if sebum or SQ, a major component of sebum, interacts with human meibum.
methodsHuman meibum was collected from the lid margin with a platinum spatula. Human sebum was collected using lipid absorbent tape. Langmuir trough technology was used to measure the rheology of surface films. Infrared spectroscopy was used to measure lipid conformation and phase transitions. We used 1H-NMR to measure composition and confirm the primary structure of SQ.
resultsThe NMR resonance near 5.2 ppm in the spectra of human sebum was from SQ which composed 28 mole percent of sebum. Both sebum and SQ lowered the lipid order of meibum. Sebum expanded meibum films at lower concentrations and condensed meibum films at higher concentrations. Sebum caused meibum to be more stable at higher pressures (greater maximum surface pressure).
conclusionsPhysiological levels of sebum would be expected to expand or fluidize meibum making it spread better and be more surface active (qualities beneficial for tear film stability). Sebum would also be expected to stabilize the tear film lipid layer, which may allow it to withstand the high shear pressure of a blink.
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