SynthesisHuman brain mapping2016
Toward a cumulative science of functional integration: A meta-analysis of psychophysiological interactions.
Synthesis in Human brain mapping, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Which software packages did researchers use to meta-analyze fMRI data? A literature survey from 2019 to 2024.Frontiers in human neuroscience · 2025Pooled it
- Functional parcellation of the default mode network: a large-scale meta-analysis.Scientific reports · 2020Pooled it
- Concurrent amygdalar and ventromedial prefrontal cortical responses during emotion processing: a meta-analysis of the effects of valence of emotion and passive exposure versus active regulation.Brain structure & function · 2020Pooled it
- Meta-analysis of reward processing in major depressive disorder reveals distinct abnormalities within the reward circuit.Translational psychiatry · 2019Pooled it
- The neural basis of motivational influences on cognitive control.Human brain mapping · 2018Pooled it
- Meta-analysis of psychophysiological interactions: Revisiting cluster-level thresholding and sample sizes.Human brain mapping · 2017Pooled it
- Structural Alterations in Large-scale Brain Networks and Their Relationship with Sleep Disturbances in the Adolescent Population.Scientific reports · 2020Trial
- Home numeracy experiences are associated with number-related brain activity and connectivity in early childhood.NPJ science of learning · 2026Article
- α -tACS Modulates Reward-Dependent Pupil Responses and Corticostriatal Connectivity.bioRxiv : the preprint server for biology · 2026Article
- Social closeness and reward sensitivity enhance corticostriatal function during experiences of shared rewards.Biological psychology · 2026Article
- Trait reward sensitivity and behavioral motivation are associated with connectivity between the default mode network and the striatum during reward anticipation.bioRxiv : the preprint server for biology · 2025Article
- Older Adults Show Altered Network Connectivity during Fairness Decisions with Similar and Dissimilar Partners.bioRxiv : the preprint server for biology · 2025Article
- Social Closeness and Reward Sensitivity Enhance Corticostriatal Function during Experiences of Shared Rewards.bioRxiv : the preprint server for biology · 2025Article
- Comparison of whole-brain task-modulated functional connectivity methods for fMRI task connectomics.Communications biology · 2024Article
- Comparison of whole-brain task-modulated functional connectivity methods for fMRI task connectomics.bioRxiv : the preprint server for biology · 2024Article
- Trait reward sensitivity modulates connectivity with the temporoparietal junction and Anterior Insula during strategic decision making.Biological psychology · 2024Article
- Trait Reward Sensitivity Modulates Connectivity with the Temporoparietal Junction and Anterior Insula during Strategic Decision Making.bioRxiv : the preprint server for biology · 2024Article
- Connectivity analyses for task-based fMRI.Physics of life reviews · 2024Review
- Corticostriatal responses to social reward are linked to trait reward sensitivity and subclinical substance use in young adults.Social cognitive and affective neuroscience · 2024Article
- Corticostriatal Responses to Social Reward are Linked to Trait Reward Sensitivity and Subclinical Substance Use in Young Adults.bioRxiv : the preprint server for biology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Much of the work in cognitive neuroscience is shifting from a focus on single brain regions to a focus on the connectivity between multiple brain regions. These inter-regional connectivity patterns contribute to a wide range of behaviors and are studied with models of functional integration. The rapid expansion of the literature on functional integration offers an opportunity to scrutinize the consistency and specificity of one of the most popular approaches for quantifying connectivity: psychophysiological interaction (PPI) analysis. We performed coordinate-based meta-analyses on 284 PPI studies, which allowed us to test (a) whether those studies consistently converge on similar target regions and (b) whether the identified target regions are specific to the chosen seed region and psychological context. Our analyses revealed two key results. First, we found that different types of PPI studies-e.g., those using seeds such as amygdala and dorsolateral prefrontal cortex (DLPFC) and contexts such as emotion and cognitive control, respectively-each consistently converge on similar target regions, thus supporting the reliability of PPI as a tool for studying functional integration. Second, we also found target regions that were specific to the chosen seed region and psychological context, indicating distinct patterns of brain connectivity. For example, the DLPFC seed reliably contributed to a posterior cingulate cortex target during cognitive control but contributed to an amygdala target in other contexts. Our results point to the robustness of PPI while highlighting common and distinct patterns of functional integration, potentially advancing models of brain connectivity. Hum Brain Mapp 37:2904-2917, 2016. © 2016 Wiley Periodicals, Inc.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.