Evidence map›Paper›PMID 27145456›Full record

ArticleOncotarget2016

The prognostic and predictive value of the lymphocyte to monocyte ratio in luminal-type breast cancer patients treated with CEF chemotherapy.

Hongfei Ji, Qijia Xuan, Caichuan Yan, Tao Liu, Abiyasi Nanding, Qingyuan Zhang

Abstract read
In one paragraph

Article in Oncotarget, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hongfei JiDepartment of Cancer Molecular and Biology, Cancer Institute, Harbin Medical University, Harbin, China.
Qijia XuanDepartment of Medical Oncology, Tumor Hospital of Harbin Medical University, Harbin, China.
Caichuan YanDepartment of Cancer Molecular and Biology, Cancer Institute, Harbin Medical University, Harbin, China.
Tao LiuDepartment of Medical Oncology, Tumor Hospital of Harbin Medical University, Harbin, China.
Abiyasi NandingDepartment of Pathology, Tumor Hospital of Harbin Medical University, Harbin, China.
Qingyuan ZhangDepartment of Cancer Molecular and Biology, Cancer Institute, Harbin Medical University, Harbin, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several reports have suggested that peripheral blood-based parameters are associated with host immunity response, which is an essential component of the pathogenesis and progression of cancer. The purpose of the present study was to identify the prognostic significance of various peripheral blood-based biomarkers and to determine the optimal cut-off value suitable for luminal breast cancer patients. We found that lymphocyte-to-monocyte ratio (LMR) was significant prognostic predictors. And the patients with a CEF regimen and LMR ratio ≥ 5.2 gained a good prognosis. This study suggested that the LMR could be regarded as an independent prognostic factor in luminal breast cancer patients. The elevated LMR level also had enhanced 5-fluorouracil sensitivity in luminal breast cancer patients.

Indexed as

Lymphocyte CountAdultAgedAntineoplastic AgentsAntineoplastic Combined Chemotherapy ProtocolsBreast NeoplasmsCell Line, TumorCyclophosphamideCytarabineDoxorubicinEpirubicinFemaleFluorouracilHumansLymphocytesMCF-7 CellsAntineoplastic AgentsCyclophosphamideCytarabineDoxorubicinEpirubicinFluorouracilTaxoids5-fluorouracilbreast cancerlymphocyte-to-monocyte ratioprognostic factor

Identifiers

PMID27145456
PMCPMC5085196

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.