Evidence map›Paper›PMID 27145447›Full record

Trial reportPsycho-oncology2017

Examination of moderators of expressive writing in patients with renal cell carcinoma: the role of depression and social support.

Kathrin Milbury, Gabriel Lopez, Amy Spelman, Christopher Wood, Surena F Matin, Nizar M Tannir, Eric Jonasch, Louis Pisters, Qi Wei, Lorenzo Cohen

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Psycho-oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 3 pooled it
3.0field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 27 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Distress Management, Version 3.2019, NCCN Clinical Practice Guidelines in Oncology.Journal of the National Comprehensive Cancer Network : JNCCN · 2019
    Guideline
  4. Effects of expressive helping writing during stem cell transplant: Randomized controlled trial.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2025
    Trial
  5. Trial
  6. Trial
  7. Article
  8. Article
  9. Article
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  11. Article
  12. Emotional state and cancer-related self-efficacy as affecting resilience and quality of life in kidney cancer patients: a cross-sectional study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. The modifying effects of social support on psychological outcomes in patients with heart failure.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2019
    Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Kathrin MilburyDepartment of Palliative, Rehabilitation & Integrative Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Gabriel LopezDepartment of Palliative, Rehabilitation & Integrative Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Amy SpelmanDepartment of Palliative, Rehabilitation & Integrative Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Christopher WoodDepartment of Urology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Surena F MatinDepartment of Urology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Nizar M TannirDepartment of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Eric JonaschDepartment of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Louis PistersDepartment of Urology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Qi WeiDepartment of Palliative, Rehabilitation & Integrative Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Lorenzo CohenDepartment of Palliative, Rehabilitation & Integrative Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
The University of Texas MD Anderson Cancer Center · US

Funding

Biobehavioral Effects of Emotional Expression in CancerR01CA090966 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI COHEN, LORENZO · 2002 to 2006
$2.5M
Couple-Based Mind-Body Program for Lung Cancer Patients and their PartnersK01AT007559 · NCCIH · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI MILBURY, KATHRIN · 2013 to 2017
$652k
NCCIH NIH HHS K01 AT007559NCI NIH HHS R01 CA090966
6 · The paper itself

Abstract

objectiveTo identify groups most likely to benefit from an Expressive Writing (EW) intervention, we examined psychosocial variables as intervention moderators. We hypothesized that EW would be particularly effective for participants with high levels of depressive symptoms and social support at study entry.

methodsPatients (n = 277; 60.6% male) with kidney cancer were randomly assigned to either an expressive (EW) or neutral writing (NW) condition. Intervention outcomes included measures of depressive symptoms (CESD), cancer-related symptoms (MDASI), fatigue (BFI), and sleep disturbances (PSQI) assessed at baseline, 1, 4, and 10 months later. Moderators were measured at baseline.

resultsAs hypothesized, depressive symptoms and social support moderated intervention efficacy. When examining both moderators simultaneously, EW appeared to be most effective in terms of cancer-related symptoms (p < 0.05) and depressive symptoms (p < 0.01) for participants with elevated depressive symptoms who received high levels of social support at baseline relative to their counterparts in the NW condition. Moreover, participants in EW with high levels of social support at baseline reported lower levels sleep disturbances (p = 0.005) than their counterparts in NW.

conclusionsRecognition of baseline depressive symptoms and social support as intervention moderators may lead to improved patient selection for EW interventions, as EW may be particularly beneficial regarding QOL outcomes for patients that have social support available including participants with depressive symptoms. EW may not be beneficial, or potentially even contraindicated, for participants lacking social support. Copyright © 2016 John Wiley & Sons, Ltd.

Indexed as

Expressed EmotionWritingAdaptation, PsychologicalCarcinoma, Renal CellDepressionFemaleHumansKidney NeoplasmsMaleMiddle AgedSocial SupportTreatment Outcomecontraindicationexpressive writingkidney cancermoderationmoderatorsquality of life

Identifiers

PMID27145447
PMCPMC5094904
OpenAlexW2346273458

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.