ArticlePloS one2016
Tracking the Time-Dependent Role of the Hippocampus in Memory Recall Using DREADDs.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 34 citations in OpenAlex.
- Article
- Adult neurogenesis improves spatial information encoding in the mouse hippocampus.Nature communications · 2024Article
- Distinct Contribution of Granular and Agranular Subdivisions of the Retrosplenial Cortex to Remote Contextual Fear Memory Retrieval.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- The Medial Prefrontal Cortex and Fear Memory: Dynamics, Connectivity, and Engrams.International journal of molecular sciences · 2021Review
- Mechanisms and plasticity of chemogenically induced interneuronal suppression of principal cells.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- mPFC spindle cycles organize sparse thalamic activation and recently active CA1 cells during non-REM sleep.eLife · 2020Article
- The Quest for the Hippocampal Memory Engram: From Theories to Experimental Evidence.Frontiers in behavioral neuroscience · 2020Review
- Coincident Pre- and Post-Synaptic Cortical Remodelling Disengages Episodic Memory from Its Original Context.Molecular neurobiology · 2019Article
- Article
- Elevation of Hippocampal Neurogenesis Induces a Temporally Graded Pattern of Forgetting of Contextual Fear Memories.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- The mysteries of remote memory.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Review
- Chemogenetic Tools for Causal Cellular and Neuronal Biology.Physiological reviews · 2018Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
The hippocampus is critical for the storage of new autobiographical experiences as memories. Following an initial encoding stage in the hippocampus, memories undergo a process of systems-level consolidation, which leads to greater stability through time and an increased reliance on neocortical areas for retrieval. The extent to which the retrieval of these consolidated memories still requires the hippocampus is unclear, as both spared and severely degraded remote memory recall have been reported following post-training hippocampal lesions. One difficulty in definitively addressing the role of the hippocampus in remote memory retrieval is the precision with which the entire volume of the hippocampal region can be inactivated. To address this issue, we used Designer Receptors Exclusively Activated by Designer Drugs (DREADDs), a chemical-genetic tool capable of highly specific neuronal manipulation over large volumes of brain tissue. We find that remote (>7 weeks after acquisition), but not recent (1-2 days after acquisition) contextual fear memories can be recalled after injection of the DREADD agonist (CNO) in animals expressing the inhibitory DREADD in the entire hippocampus. Our data demonstrate a time-dependent role of the hippocampus in memory retrieval, supporting the standard model of systems consolidation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.