Evidence map›Paper›PMID 27145003›Full record

ArticleEndocrinology2016

Cardiometabolic Effects of Chronic Hyperandrogenemia in a New Model of Postmenopausal Polycystic Ovary Syndrome.

Carolina Dalmasso, Rodrigo Maranon, Chetan Patil, Elizabeth Bui, Mohadetheh Moulana, Howei Zhang, Andrew Smith, Licy L Yanes Cardozo, Jane F Reckelhoff

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Endocrinology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Carolina DalmassoDepartments of Physiology and Biophysics (C.D., R.M., C.P., L.L.Y.C., J.F.R.), Medicine (E.B., R.M., L.L.Y.C.), Psychiatry (M.M.), Radiology (H.Z., A.S.), Endocrinology (L.L.Y.C.), and Women's Health Research Center (C.D., R.M., C.P., L.L.Y.C., J.F.R.), University of Mississippi Medical Center, Jackson, Mississippi 39216.
Rodrigo MaranonDepartments of Physiology and Biophysics (C.D., R.M., C.P., L.L.Y.C., J.F.R.), Medicine (E.B., R.M., L.L.Y.C.), Psychiatry (M.M.), Radiology (H.Z., A.S.), Endocrinology (L.L.Y.C.), and Women's Health Research Center (C.D., R.M., C.P., L.L.Y.C., J.F.R.), University of Mississippi Medical Center, Jackson, Mississippi 39216.
Chetan PatilDepartments of Physiology and Biophysics (C.D., R.M., C.P., L.L.Y.C., J.F.R.), Medicine (E.B., R.M., L.L.Y.C.), Psychiatry (M.M.), Radiology (H.Z., A.S.), Endocrinology (L.L.Y.C.), and Women's Health Research Center (C.D., R.M., C.P., L.L.Y.C., J.F.R.), University of Mississippi Medical Center, Jackson, Mississippi 39216.
Elizabeth BuiDepartments of Physiology and Biophysics (C.D., R.M., C.P., L.L.Y.C., J.F.R.), Medicine (E.B., R.M., L.L.Y.C.), Psychiatry (M.M.), Radiology (H.Z., A.S.), Endocrinology (L.L.Y.C.), and Women's Health Research Center (C.D., R.M., C.P., L.L.Y.C., J.F.R.), University of Mississippi Medical Center, Jackson, Mississippi 39216.
Mohadetheh MoulanaDepartments of Physiology and Biophysics (C.D., R.M., C.P., L.L.Y.C., J.F.R.), Medicine (E.B., R.M., L.L.Y.C.), Psychiatry (M.M.), Radiology (H.Z., A.S.), Endocrinology (L.L.Y.C.), and Women's Health Research Center (C.D., R.M., C.P., L.L.Y.C., J.F.R.), University of Mississippi Medical Center, Jackson, Mississippi 39216.
Howei ZhangDepartments of Physiology and Biophysics (C.D., R.M., C.P., L.L.Y.C., J.F.R.), Medicine (E.B., R.M., L.L.Y.C.), Psychiatry (M.M.), Radiology (H.Z., A.S.), Endocrinology (L.L.Y.C.), and Women's Health Research Center (C.D., R.M., C.P., L.L.Y.C., J.F.R.), University of Mississippi Medical Center, Jackson, Mississippi 39216.
Andrew SmithDepartments of Physiology and Biophysics (C.D., R.M., C.P., L.L.Y.C., J.F.R.), Medicine (E.B., R.M., L.L.Y.C.), Psychiatry (M.M.), Radiology (H.Z., A.S.), Endocrinology (L.L.Y.C.), and Women's Health Research Center (C.D., R.M., C.P., L.L.Y.C., J.F.R.), University of Mississippi Medical Center, Jackson, Mississippi 39216.
Licy L Yanes CardozoDepartments of Physiology and Biophysics (C.D., R.M., C.P., L.L.Y.C., J.F.R.), Medicine (E.B., R.M., L.L.Y.C.), Psychiatry (M.M.), Radiology (H.Z., A.S.), Endocrinology (L.L.Y.C.), and Women's Health Research Center (C.D., R.M., C.P., L.L.Y.C., J.F.R.), University of Mississippi Medical Center, Jackson, Mississippi 39216.
Jane F ReckelhoffDepartments of Physiology and Biophysics (C.D., R.M., C.P., L.L.Y.C., J.F.R.), Medicine (E.B., R.M., L.L.Y.C.), Psychiatry (M.M.), Radiology (H.Z., A.S.), Endocrinology (L.L.Y.C.), and Women's Health Research Center (C.D., R.M., C.P., L.L.Y.C., J.F.R.), University of Mississippi Medical Center, Jackson, Mississippi 39216.

Funding

STRUCTURAL VASCULAR ADAPTATION OF THE MICROCIRCULATIONP01HL051971 · NHLBI · UNIVERSITY OF MISSISSIPPI MEDICAL CENTER · PI HESTER, ROBERT L · 1993 to 2018
$39.4M
The role of leptin in autoimmune-associated hypertensionP20GM104357 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI TAYLOR, ERIN BASSFORD · 2013 to 2022
$23.4M
HUMORAL FACTORS IN GENDER DIFFERENCES IN BP CONTROLR01HL066072 · NHLBI · UNIVERSITY OF MISSISSIPPI MEDICAL CENTER · PI RECKELHOFF, JANE F · 2001 to 2015
$3.9M
Gender and susceptibility to kidney damage in high BP.R01HL069194 · NHLBI · UNIVERSITY OF MISSISSIPPI MEDICAL CENTER · PI RECKELHOFF, JANE F · 2001 to 2010
$2.5M
NHLBI NIH HHS P01 HL051971NHLBI NIH HHS R01 HL066072NHLBI NIH HHS R01 HL069194NIGMS NIH HHS P20 GM104357
6 · The paper itself

Abstract

Postmenopausal women who have had polycystic ovary syndrome (PCOS) and chronic hyperandrogenemia may be at a greater risk for cardiovascular disease than normoandrogenemic postmenopausal women. The cardiometabolic effect of chronic hyperandrogenemia in women with PCOS after menopause is unclear. The present study was performed to test the hypothesis that chronic hyperandrogenemia in aging female rats would have more deleterious effects on metabolic function, blood pressure, and renal function than in normoandrogenemic age-matched females. Female Sprague Dawley were implanted continuously, beginning at 4-5 weeks, with dihydrotestosterone (postmenopausal hyperandrogenemic female [PMHAF]) or placebo pellets (controls), and were studied at 13 months of age. Plasma DHT was 3-fold higher, and estradiol was 90% lower in PMHAF than controls. Body weights were higher; EchoMRI showed greater fat and lean mass; and computed tomography showed more sc and visceral adiposity in PMHAF, but with similar femur length compared with controls. Insulin resistance was present in PMHAF with higher plasma insulin, normal fasting blood glucose, abnormal oral glucose tolerance test, and higher nonfasting blood glucose. Blood pressure (radiotelemetry) was significantly higher and heart rate was lower, and renal function (glomerular filtration rate) was reduced by 40% in PMHAF. Thus the aging chronically hyperandrogenemic female rat is a new model of postmenopausal PCOS, which exhibits insulin resistance and visceral obesity, hypertension, and impairment in renal function. This new model provides a unique tool to study the deleterious effects of chronic androgen excess in postmenopausal females rats.

Indexed as

PostmenopauseAnimalsBlood GlucoseBody WeightCardiovascular DiseasesDisease Models, AnimalFemaleGlucose Tolerance TestHyperandrogenismInsulin ResistancePolycystic Ovary SyndromeRatsRats, Sprague-DawleyBlood Glucose

Identifiers

PMID27145003
PMCPMC4929551

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.