ArticlePloS one2016
The TNFα-Transgenic Rat: Hippocampal Synaptic Integrity, Cognition, Function, and Post-Ischemic Cell Loss.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
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- The Memory Orchestra: Contribution of Astrocytes.Neuroscience bulletin · 2023Review
- Beneficial effects of arthrocen on neuroinflammation and behavior like depression in stroke in a murine model.Food science & nutrition · 2023Article
- Global trends and prospects about synaptic plasticity in Alzheimer's disease: a bibliometric analysis.Frontiers in aging neuroscience · 2023Review
- Microglia in Alzheimer's disease: pathogenesis, mechanisms, and therapeutic potentials.Frontiers in aging neuroscience · 2023Review
- Inflammation at the crossroads of COVID-19, cognitive deficits and depression.Neuropharmacology · 2022Review
- Microglia regulation of synaptic plasticity and learning and memory.Neural regeneration research · 2022Review
- Learning Deficits Induced by High-Calorie Feeding in the Rat are Associated With Impaired Brain Kynurenine Pathway Metabolism.International journal of tryptophan research : IJTR · 2022Article
- Paracetamol (acetaminophen) rescues cognitive decline, neuroinflammation and cytoskeletal alterations in a model of post-operative cognitive decline (POCD) in middle-aged rats.Scientific reports · 2021Article
- Microglia Polarization in Alzheimer's Disease: Mechanisms and a Potential Therapeutic Target.Frontiers in aging neuroscience · 2021Review
- Tumour Necrosis Factor in Neuroplasticity, Neurogenesis and Alcohol Use Disorder.Brain plasticity (Amsterdam, Netherlands) · 2020Review
- Tumor Necrosis Factor-Alpha Alters Electrophysiological Properties of Rabbit Hippocampal Neurons.Journal of Alzheimer's disease : JAD · 2019Article
- Tumor Necrosis Factor and Interleukin-1Neural plasticity · 2018Review
- Infectious immunity in the central nervous system and brain function.Nature immunology · 2017Review
- The role of cytokines in modulating learning and memory and brain plasticity.Brain and neuroscience advancesReview
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The cytokine, tumor necrosis factor α (TNFα), is a key regulator of neuroinflammation linked to numerous neurodegenerative conditions and diseases. The present study used transgenic rats that overexpress a murine TNFα gene, under the control of its own promoter, to investigate the impact of chronically elevated TNFα on hippocampal synaptic function. Neuronal viability and cognitive recovery in TNFα Tg rats were also determined following an ischemic insult arising from reversible middle cerebral artery occlusion (MCAO). Basal CA3-CA1 synaptic strength, recorded in acute brain slices, was not significantly different between eight-week-old TNFα Tg rats and non-Tg rats. In contrast, slices from TNFα Tg rats showed significantly greater levels of long-term potentiation (LTP) in response to 100 Hz stimulation, suggesting that synaptic networks may be hyperexcitable in the context of elevated TNFα. Cognitive and motor deficits (assessed on the Morris Water Maze and Rotarod task, respectively) were present in TNFα Tg rats in the absence of significant differences in the loss of cortical and hippocampal neurons. TNF overexpression exacerbated MCAO-dependent deficits on the rotarod, but ameliorated cortical neuron loss in response to MCAO.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.