Observational studyThe Journal of clinical endocrinology and metabolism2016
Association of Hypoalbuminemia With Osteoporosis: Analysis of the National Health and Nutrition Examination Survey.
Observational study in The Journal of clinical endocrinology and metabolism, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 58 citations in OpenAlex.
- Association of composite inflammatory indicators with osteoporosis and sarcopenia in type 2 diabetes mellitus: the mediating role of inflammation.Journal of endocrinological investigation · 2026Article
- Factors associated with intracapsular versus extracapsular hip fracture patterns in elderly patients following low-energy falls: a retrospective analysis from a single tertiary-care center in China.Frontiers in medicine · 2026Article
- The impact of catalpol on osteogenic differentiation of the jaw bone marrow mesenchymal stem cells on the basis of network pharmacology, molecular docking and experimental validation.BMC oral health · 2025Article
- The effect of hypersensitive C-reactive protein to albumin ratio on the risk of fragility fracture in the Chinese male population.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025Article
- Canola Protein Hydrolysates Show Osteogenic Activity in MC3T3-E1 Cells.Journal of food science · 2025Article
- Association Between the Nutritional Inflammatory Index and Obstructive Sleep Apnea Risk: Insights from the NHANES 2015-2020 and Mendelian Randomization Analyses.Healthcare (Basel, Switzerland) · 2025Article
- Association between the Triglyceride-glucose index and fragility fractures among US adults: insights from NHANES.Diabetology & metabolic syndrome · 2025Article
- Association between Geriatric Nutritional Risk Index and all-cause mortality in individuals with osteoporotic fractures: a retrospective cohort study.Aging clinical and experimental research · 2025Article
- Development of an Online Nomogram for Predicting Postoperative Hypoalbuminemia in Older Adults Following Femoral Neck Fractures.Clinical interventions in aging · 2025Article
- The relationship between preoperative hypoalbuminemia and postoperative subsyndromal delirium in elderly hip fracture patients: a prospective study.Frontiers in medicine · 2025Article
- Neutrophil-to-albumin ratio: a novel predictor of osteoporosis in rheumatoid arthritis.Frontiers in immunology · 2025Article
- The association between the albumin to globulin ratio and thoracic spine bone mineral density in adolescents: NHANES 2011-2016.Frontiers in nutrition · 2025Article
- Relationship between albumin and osteoporosis in patients with type 2 diabetes mellitus.Frontiers in endocrinology · 2025Article
- Is it time to Reassess The Role of Preoperative HypoalbuminemiaAmong Geriatric Distal Femur Fracture Patients?Archives of orthopaedic and trauma surgery · 2024Article
- Association of geriatric nutritional risk index with bone mineral density and osteoporosis in postmenopausal elderly women with T2DM.Asia Pacific journal of clinical nutrition · 2024Article
- The predictive value of albumin to alkaline phosphatase ratio for vertebral refractures in postmenopausal women.Journal of bone and mineral metabolism · 2024Article
- High C-reactive protein-to-albumin ratio levels are associated with osteoporosis in patients with primary biliary cholangitis.Frontiers in endocrinology · 2024Article
- Association between advanced lung cancer inflammation index and osteoporosis in patients with type 2 diabetes mellitus: evidence from NHANES.Frontiers in endocrinology · 2024Article
- Relationships among body weight, lipids and bone mass in elderly individuals with fractures: A case-control study.World journal of orthopedics · 2023Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
contextThe association of hypoalbuminemia with osteoporosis in human studies is controversial.
objectiveWe tested the independent association between hypoalbuminemia and osteoporosis in a national dataset.
designThis is a cross-sectional observation. SETTING AND
participantsParticipants are individuals selected from the National Health and Nutrition Examination Survey (NHANES) with available clinical, laboratory, and densitometry data from the 2005-2010 and 2013-2014 cycles. EXPOSURE: Exposure is hypoalbuminemia defined as serum albumin <3.5 g/dL.
main outcome measureOsteoporosis is defined as bone mineral density of ≤2.5 SD below the mean peak bone mass of young, healthy adults. Analysis took into account the hidden variance and the weighting methodology pertinent to analysis of NHANES.
resultsOverall, 15 539 individuals were included. The mean age was 48.6 years (SE = 0.27). Fifty percent of the individuals were male, and 10.2% were of the black race. There was a graded decrease in the rate of osteoporosis from 15.2% at albumin <3.5 g/dL to 2.6% at albumin >4 g/dL (P = .007) at the femoral neck and from 11.0 to 1.4% at total femur (P = .009). In a fully adjusted model, the odds of osteoporosis with hypoalbuminemia were 5.37-fold (95% confidence interval [CI], 1.43 to 20.20; P = .014) at the femoral neck, 12.46-fold (95% CI, 3.24 to 48.01; P < .001) at total femur, and 4.59-fold (95% CI, 1.49 to 14.16; P = .025) at the lumbar spine higher as compared to albumin >4 mg/dL.
conclusionIn the NHANES dataset, we report an independent association of osteoporosis with hypoalbuminemia at different anatomical sites.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.