ArticleHuman brain mapping2016
The functional connectome of cognitive reserve.
Article in Human brain mapping, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 1 of them a synthesis that pooled it.
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Who cites it
63 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A Systematic Review for Functional Neuroimaging Studies of Cognitive Reserve Across the Cognitive Aging Spectrum.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2018Pooled it
- Efficacy of oxcarbazepine in treating focal epilepsy based on resting-state EEG functional connectivity and power spectral analyses.Acta epileptologica · 2026Article
- The multi-dimensional spectrum of radiologically isolated syndrome: a systematic review of cognitive and psychosocial evidence.Acta neurologica Belgica · 2026Review
- Modeling and evaluating longitudinal brain maintenance and cognitive reserve using episodic memory, brain structure, and functional connectivity in older adults.GeroScience · 2026Article
- Do cognitive reserve proxies capture a common neural signature? A systematic review and meta-analysis of task-based fMRI studies.Psychoradiology · 2026Review
- Modelling cognitive outcomes in the UK Biobank: Education, noradrenaline and frontoparietal networks.PloS one · 2026Article
- Sex differences in brain network functional connectivity and their association with gene expression profiles in major depressive disorder: a REST-meta-MDD project-based study.Brain imaging and behavior · 2025Article
- Associations between serum lipid levels and cognitive impairment in hypertensive patients: a case-control study.BMC neurology · 2025Article
- Precision Surgery for Glioblastomas.Journal of personalized medicine · 2025Review
- Article
- Cognitive and physical activities are associated with cognitive resilience in a memory clinic cohort.Brain communications · 2025Article
- Beyond Focal Lesions: Dynamical Network Effects of White Matter Hyperintensities.Human brain mapping · 2024Article
- Does functional system segregation mediate the effects of lifestyle on cognition in older adults?Neurobiology of aging · 2024Article
- Association between sleep quality and cognitive impairment in older adults hypertensive patients in China: a case-control study.Frontiers in public health · 2024Article
- Cerebral Small Vessel Disease: Early-Life Antecedents and Long-Term Implications for the Brain, Aging, Stroke, and Dementia.Hypertension (Dallas, Tex. : 1979) · 2024Review
- Brain network correlates of affective symptoms in aMCI.Aging brain · 2024Article
- Short communication: Lifetime musical activity and resting-state functional connectivity in cognitive networks.PloS one · 2024Article
- The rising role of cognitive reserve and associated compensatory brain networks in spinocerebellar ataxia type 2.Journal of neurology · 2023Article
- Connectome-based predictive modelling of cognitive reserve using task-based functional connectivity.The European journal of neuroscience · 2023Article
- People with Primary Progressive Multiple Sclerosis Have a Lower Number of Central Memory T Cells and HLA-DRCells · 2023Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cognitive Reserve (CR) designates the brain's capacity to actively cope with insults through a more efficient use of its resources/networks. It was proposed in order to explain the discrepancies between the observed cognitive ability and the expected capacity for an individual. Typical proxies of CR include education and Intelligence Quotient but none totally account for the variability of CR and no study has shown if the brain's greater efficiency associated with CR can be measured. We used a validated model to estimate CR from the residual variance in memory and general executive functioning, accounting for both brain anatomical (i.e., gray matter and white matter signal abnormalities volume) and demographic variables (i.e., years of formal education and sex). Functional connectivity (FC) networks and topological properties were explored for associations with CR. Demographic characteristics, mainly accounted by years of formal education, were associated with higher FC, clustering, local efficiency and strength in parietal and occipital regions and greater network transitivity. Higher CR was associated with a greater FC, local efficiency and clustering of occipital regions, strength and centrality of the inferior temporal gyrus and higher global efficiency. Altogether, these findings suggest that education may facilitate the brain's ability to form segregated functional groups, reinforcing the view that higher education level triggers more specialized use of neural processing. Additionally, this study demonstrated for the first time that CR is associated with more efficient processing of information in the human brain and reinforces the existence of a fine balance between segregation and integration. Hum Brain Mapp 37:3310-3322, 2016.. © 2016 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.