ArticlePloS one2016
Elevated Serum Uric Acid Is Associated with Greater Bone Mineral Density and Skeletal Muscle Mass in Middle-Aged and Older Adults.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.
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Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.
- The association between serum uric acid level and the risk of fractures: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017Pooled it
- Opposing associations of muscle and fat mass changes on serum uric acid levels: a 2-year longitudinal cohort study.The Korean journal of internal medicine · 2026Article
- Low initial body fat percentage exacerbates skeletal muscle loss and increases the risk of hyperuricemia during high-altitude acclimatization in young men.Frontiers in nutrition · 2026Article
- Muscle quality index and hyperuricemia: adipose tissue as a mediator.Frontiers in endocrinology · 2025Article
- The dual association of serum uric acid with the functional outcomes of patients after hip arthroplasty: 1-year follow-up study.Frontiers in surgery · 2025Article
- The impact of uric acid on musculoskeletal diseases: clinical associations and underlying mechanisms.Frontiers in endocrinology · 2025Review
- Inverse association between uric acid levels and muscle quality index in adults: a cross-sectional analysis of NHANES 2011-2014.BMC public health · 2024Article
- Skeletal muscle mass and quality in gout patients versus non-gout controls: A computed tomography imaging study.Joint bone spine · 2024Article
- Cohort Profile: Guangzhou Nutrition and Health Study (GNHS): A Population-based Multi-omics Study.Journal of epidemiology · 2024Article
- L-shaped association between lean body mass to visceral fat mass ratio with hyperuricemia: a cross-sectional study.Lipids in health and disease · 2024Article
- The correlations of serum uric acid with lean mass, fat mass and grip strength in adolescents aged 12-19 years.Frontiers in endocrinology · 2024Article
- Cross-sectional analysis of the correlation between serum uric acid and trabecular bone score: NHANES 2005-2008.Scientific reports · 2023Article
- Associations of early pregnancy serum uric acid levels with risk of gestational diabetes and birth outcomes: a retrospective cohort study.BMC endocrine disorders · 2023Article
- Excessively Increased Skeletal Muscle Mass of the Bilateral Lower Limbs is Associated with Hyperuricemia in Females with Polycystic Ovarian Syndrome.Reproductive sciences (Thousand Oaks, Calif.) · 2023Article
- Association between serum uric acid levels and bone mineral density in patients with osteoporosis: a cross-sectional study.BMC musculoskeletal disorders · 2023Article
- Associations Between Low Serum Urate, Body Composition, and Mortality.Arthritis & rheumatology (Hoboken, N.J.) · 2023Article
- Association between serum uric acid level and bone mineral density in men more than 50 years of age.Frontiers in endocrinology · 2023Observational
- Causality between urate levels with sarcopenia-related traits: a bi-directional Mendelian randomization study.Frontiers in endocrinology · 2023Article
- Risk factors of osteoporosis in elderly inpatients: A cross-sectional single-centre study.Frontiers in aging · 2023Article
- Relationship between bone mineral density and hyperuricemia in obesity: A cross-sectional study.Frontiers in endocrinology · 2023Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivePrevious studies have suggested a positive link between serum uric acid (UA) and bone mineral density (BMD). In this study, we re-examined the association between UA and BMD and further explored whether this was mediated by skeletal muscle mass in a general Chinese population.
methodThis community-based cross-sectional study was conducted among 3079 (963 men and 2116 women) Chinese adults aged 40-75 years. Face-to-face interviews and laboratory analyses were performed to determine serum UA and various covariates. Dual-energy X-ray absorptiometry was used to assess the BMD and appendicular skeletal muscle mass. The skeletal muscle mass index (SMI = ASM/Height(2), kg/m(2)) for the total limbs, arms, and legs was then calculated.
resultsThe serum UA was graded and, in general, was significantly and positively associated with the BMD and muscle mass, after adjustment for multiple covariates in the total sample. Compared with participants in lowest quartile of UA, those participants in highest quartile showed a 2.3%(whole body), 4.1%(lumbar spine), 2.4%(total hip), and 2.0% (femoral neck) greater BMDs. The mean SMIs in the highest (vs. lowest) quartile increased by 2.7% (total), 2.5% (arm), 2.7% (leg) respectively. In addition, path analysis suggested that the favorable association between UA and BMD might be mediated by increasing SMI.
conclusionThe elevated serum UA was associated with a higher BMD and a greater muscle mass in a middle-aged and elderly Chinese population and the UA-BMD association was partly mediated by muscle mass.
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