Evidence map›Paper›PMID 27144618›Full record

ArticleGastroenterology2016

Fundamentals of Neurogastroenterology: Basic Science.

Stephen Vanner, Beverley Greenwood-Van Meerveld, Gary Mawe, Terez Shea-Donohue, Elena F Verdu, Jackie Wood, David Grundy

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Gastroenterology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04716738 (Sexual Dysfunction, Quality of Life and Visceral Hyperalgesia in Women With Irritable Bowel Syndrome), which is not on this map. Cited by 52 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 2 pooled it
21.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04716738 unknown statusnot on this mapstarted 2023, after this paper: background citation

Sexual Dysfunction, Quality of Life and Visceral Hyperalgesia in Women With Irritable Bowel Syndrome

Typeobservational_patient_registrySponsorHospital General de MexicoRan2023 to 2023Enrolled20ConditionsIrritable Bowel Syndrome, Sexual DysfunctionArmsBlood analyses and coprological
3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 2 syntheses or guidelines pooled it, 363 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 7 institutions in 3 countries.

Stephen VannerGastrointestinal Diseases Research Unit, Kingston General Hospital, Kingston, Ontario, Canada. Electronic address: vanners@hdh.kari.net.
Beverley Greenwood-Van MeerveldOklahoma Center for Neuroscience, Department of Physiology, VA Medical Center, University of Oklahoma, Health Sciences Center, Oklahoma City, Oklahoma.
Gary MaweDepartment of Neurological Sciences, Pharmacology and Medicine Division, Gastroenterology and Hepatology, University of Vermont, Burlington, Vermont.
Terez Shea-DonohueDepartment of Medicine and Physiology, University of Maryland, School of Medicine, Baltimore, Maryland.
Elena F VerduFarncombe Family Digestive Health Research Institute, McMaster University, Health Sciences Center, Hamilton, Ontario, Canada.
Jackie WoodDepartment of Physiology and Cell Biology, The Ohio State University, Columbus, Ohio.
David GrundyDepartment of Biomedical Science, University of Sheffield, Sheffield, United Kingdom.
Kingston General Hospital · CAPopulation Health Research Institute · CAThe Ohio State University · USUniversity of Maryland, Baltimore · USUniversity of Oklahoma Health Sciences Center · USUniversity of Sheffield · GBUniversity of Vermont · US

Funding

Neuronal Excitability and Motility in ColitisR01DK062267 · NIDDK · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI MAWE, GARY M · 2002 to 2016
$3.3M
Novel Cytokine Regulation of Gut Function and InflammationR01DK083418 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI SHEA-DONOHUE, TEREZ · 2009 to 2013
$1.5M
Central Mechanisms Modulating Visceral SensitivityI01BX002188 · VA · OKLAHOMA CITY VA MEDICAL CENTER · PI HOUCHEN, COURTNEY WAYNE · 2013 to 2022
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BLR&D Research Career Scientist Award ApplicationIK6BX003610 · VA · OKLAHOMA CITY VA MEDICAL CENTER · PI GREENWOOD-VAN MEERVELD, BEVERLEY · 2017 to 2021
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BLRD VA I01 BX002188BLRD VA IK6 BX003610NIDDK NIH HHS R01 DK062267NIDDK NIH HHS R01 DK083418
6 · The paper itself

Abstract

This review examines the fundamentals of neurogastroenterology that may underlie the pathophysiology of functional GI disorders (FGIDs). It was prepared by an invited committee of international experts and represents an abbreviated version of their consensus document that will be published in its entirety in the forthcoming book and online version entitled ROME IV. It emphasizes recent advances in our understanding of the enteric nervous system, sensory physiology underlying pain, and stress signaling pathways. There is also a focus on neuroimmmune signaling and intestinal barrier function, given the recent evidence implicating the microbiome, diet, and mucosal immune activation in FGIDs. Together, these advances provide a host of exciting new targets to identify and treat FGIDs and new areas for future research into their pathophysiology.

Indexed as

enteric nervous systemmucosal barrier functionneuroimmune signalingsensory physiology

Identifiers

PMID27144618
PMCPMC5673591
OpenAlexW2065638022

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.