ArticleMolecules (Basel, Switzerland)2016
Design, Synthesis and Evaluation of Antiproliferative Activity of New Benzimidazolehydrazones.
Article in Molecules (Basel, Switzerland), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Hydrazone-heterocyclic hybrids as promising anticancer agents: a comprehensive review.RSC advances · 2026Review
- Recent achievements in the synthesis of benzimidazole derivatives.RSC advances · 2023Review
- A Review of Approaches to the Metallic and Non-Metallic Synthesis of Benzimidazole (BnZ) and Their Derivatives for Biological Efficacy.Molecules (Basel, Switzerland) · 2023Review
- Heteroaromatic Diazirines Are Essential Building Blocks for Material and Medicinal Chemistry.Molecules (Basel, Switzerland) · 2023Review
- Design, Synthesis and Evaluation of New Multifunctional Benzothiazoles as Photoprotective, Antioxidant and Antiproliferative Agents.Molecules (Basel, Switzerland) · 2022Article
- Modulation Effect on Tubulin Polymerization, Cytotoxicity and Antioxidant Activity of 1H-Benzimidazole-2-Yl Hydrazones.Molecules (Basel, Switzerland) · 2022Article
- New Potential Agents for Malignant Melanoma Treatment-Most Recent Studies 2020-2022.International journal of molecular sciences · 2022Review
- Benzothiazole Derivatives as Multifunctional Antioxidant Agents for Skin Damage: Structure-Activity Relationship of a Scaffold Bearing a Five-Membered Ring System.Antioxidants (Basel, Switzerland) · 2022Article
- Synthesis of Benzimidazole-Sulfonyl Derivatives and Their Biological Activities.Biochemistry research international · 2022Review
- Synthesis, Crystal Structure and Bioactivity of Phenazine-1-carboxylic Acylhydrazone Derivatives.Molecules (Basel, Switzerland) · 2021Article
- Synthesis of Antimicrobial Benzimidazole-Pyrazole Compounds and Their Biological Activities.Antibiotics (Basel, Switzerland) · 2021Review
- In-Vitro Evaluation of Antioxidant, Antiproliferative and Photo-Protective Activities of Benzimidazolehydrazone Derivatives.Pharmaceuticals (Basel, Switzerland) · 2020Article
- Benzimidazole scaffolds as promising antiproliferative agents: a review.BMC chemistry · 2019Review
- Synthesis and In Vitro Anticancer Activity of Novel Dehydroabietic Acid-Based Acylhydrazones.Molecules (Basel, Switzerland) · 2017Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The synthesis and antiproliferative activity of new benzimidazole derivatives bearing an hydrazone mojety at the 2-position is described. The new N'-(4-arylidene)-1H-benzo[d]imidazole-2-carbohydrazides were evaluated for their cytostatic activity toward the murine leukemia (L1210), human T-cell leukemia (CEM), human cervix carcinoma (HeLa) and human pancreas carcinoma cells (Mia Paca-2). A preliminary structure-activity relationship could be defined. Some of the compounds possess encouraging and consistent antiproliferative activity, having IC50 values in the low micromolar range.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.