ArticleOncotarget2016
microRNA-802/Rnd3 pathway imposes on carcinogenesis and metastasis of fine particulate matter exposure.
Article in Oncotarget, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 38 citations in OpenAlex.
- Review
- Hallmarks of lung cancer driven by inhalable particulate matter: From cell-intrinsic oncogenic traits to microenvironment remodeling.Innovation (Cambridge (Mass.)) · 2026Review
- Rnd3 regulates lung cancer cell invasion and migration independently of ROCK1 signaling via alpha 5 integrin modulation.Life science alliance · 2026Article
- Global impact of air pollution on cancer: causal evidence and health inequities across regions from 1990 to 2021.BMC cancer · 2025Article
- A novel miR-4536-3p inhibition ameliorates Alzheimer's disease by reducing Aβ accumulation and tau phosphorylation.Alzheimer's research & therapy · 2025Article
- Genomic Basis for Individual Differences in Susceptibility to the Neurotoxic Effects of Diesel Exhaust.International journal of molecular sciences · 2022Article
- Increased alveolar epithelial TRAF6 via autophagy-dependent TRIM37 degradation mediates particulate matter-induced lung metastasis.Autophagy · 2022Article
- Role of air pollutants in airway epithelial barrier dysfunction in asthma and COPD.European respiratory review : an official journal of the European Respiratory Society · 2022Review
- The Correlation of PM2.5 Exposure with Acute Attack and Steroid Sensitivity in Asthma.BioMed research international · 2022Review
- HER2-specific chimeric antigen receptor-T cells for targeted therapy of metastatic colorectal cancer.Cell death & disease · 2021Article
- Dysfunction of miR-802 in tumors.Journal of clinical laboratory analysis · 2021Review
- Genomic Approach to the Assessment of Adverse Effects of Particulate Matters on Skin Cancer and Other Disorders and Underlying Molecular Mechanisms.Journal of cancer prevention · 2021Review
- Identification of MYLIP gene and miRNA-802 involved in the growth and metastasis of cervical cancer cells.Cancer biomarkers : section A of Disease markers · 2021Article
- Outdoor air pollution and cancer: An overview of the current evidence and public health recommendations.CA: a cancer journal for clinicians · 2020Review
- MiRNA-802 suppresses proliferation and migration of epithelial ovarian cancer cells by targeting YWHAZ.Journal of ovarian research · 2019Article
- Colonic Injuries Induced by Inhalational Exposure to Particulate-Matter Air Pollution.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2019Article
- Article
- Function of PM2.5 in the pathogenesis of lung cancer and chronic airway inflammatory diseases.Oncology letters · 2018Review
- microRNA-802 inhibits epithelial-mesenchymal transition through targeting flotillin-2 in human prostate cancer.Bioscience reports · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent studies have linked ambient fine particulate matter (PM2.5) to increased lung cancer mortality and morbidity. However, the underlying mechanism causing the adverse effects of PM2.5 is less clear. In the present study, post-transcriptional profiling was used to explore biological pathways involved in PM2.5-induced pulmonary disorders. The carcinogenesis and metastasis of PM2.5 exposure were evaluated by long-term PM2.5 exposure tests. We observed dysregulation of actin in A549 cells line and dysplasia in the lungs of mice exposed to PM2.5. Both PM2.5-exposed cells and animals showed increased Rnd3 expression levels. Moreover, miR-802 mimics rescued actin disorganization in vitro and alveolitis in vivo. Long-term exposure to PM2.5 promoted carcinogenesis and metastasis of pulmonary cells. Decreased miR-802 expression levels in the serum samples of PM2.5-treated mice and individuals from moderately polluted cities were observed. Increased Rnd3 expression levels in lung cancers tissues have been identified by a genome database TCGA, and have been linked to less overall survival probabilities of lung cancer patients. Our findings suggest that dysregulation of actin cytoskeleton and down-regulation of miR-802 expression might be the underlying mechanism involved in the adverse effects of PM2.5 exposure. In addition, long-term exposure to PM2.5 demonstrated strong associations with malignant pulmonary disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.