Evidence map›Paper›PMID 27144213›Full record

ArticleNeurology(R) neuroimmunology & neuroinflammation2016

IL-17 production by CSF lymphocytes as a biomarker for cerebral vasculitis.

Vivien Thom, Sabrina Schmid, Mathias Gelderblom, Romy Hackbusch, Manuela Kolster, Simon Schuster, Götz Thomalla, Oliver Keminer, Ole Pleß, Christian Bernreuther and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology(R) neuroimmunology & neuroinflammation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 34 citations in OpenAlex.

  1. Biomarkers in Primary Systemic Vasculitides: Narrative Review.International journal of molecular sciences · 2026
    Review
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  14. Primary angiitis of the central nervous system: diagnosis and treatment.Therapeutic advances in neurological disorders · 2018
    Review
  15. Review
  16. Alphabet soup.Neurology(R) neuroimmunology & neuroinflammation · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Vivien ThomDepartments of Immunology (V.T., R.H., M.K., E.T.), Neurology (V.T., S.S., M.G., S.S., G.T., C.G., T.M.), Neuropathology (C.B., M.G.), and Medical Biometry and Epidemiology (K.W.), University Medical Center Hamburg-Eppendorf; and IME Screening Port (O.K., O.P.), Fraunhofer Institute for Molecular Biology and Applied Ecology, Hamburg, Germany.
Sabrina SchmidDepartments of Immunology (V.T., R.H., M.K., E.T.), Neurology (V.T., S.S., M.G., S.S., G.T., C.G., T.M.), Neuropathology (C.B., M.G.), and Medical Biometry and Epidemiology (K.W.), University Medical Center Hamburg-Eppendorf; and IME Screening Port (O.K., O.P.), Fraunhofer Institute for Molecular Biology and Applied Ecology, Hamburg, Germany.
Mathias GelderblomDepartments of Immunology (V.T., R.H., M.K., E.T.), Neurology (V.T., S.S., M.G., S.S., G.T., C.G., T.M.), Neuropathology (C.B., M.G.), and Medical Biometry and Epidemiology (K.W.), University Medical Center Hamburg-Eppendorf; and IME Screening Port (O.K., O.P.), Fraunhofer Institute for Molecular Biology and Applied Ecology, Hamburg, Germany.
Romy HackbuschDepartments of Immunology (V.T., R.H., M.K., E.T.), Neurology (V.T., S.S., M.G., S.S., G.T., C.G., T.M.), Neuropathology (C.B., M.G.), and Medical Biometry and Epidemiology (K.W.), University Medical Center Hamburg-Eppendorf; and IME Screening Port (O.K., O.P.), Fraunhofer Institute for Molecular Biology and Applied Ecology, Hamburg, Germany.
Manuela KolsterDepartments of Immunology (V.T., R.H., M.K., E.T.), Neurology (V.T., S.S., M.G., S.S., G.T., C.G., T.M.), Neuropathology (C.B., M.G.), and Medical Biometry and Epidemiology (K.W.), University Medical Center Hamburg-Eppendorf; and IME Screening Port (O.K., O.P.), Fraunhofer Institute for Molecular Biology and Applied Ecology, Hamburg, Germany.
Simon SchusterDepartments of Immunology (V.T., R.H., M.K., E.T.), Neurology (V.T., S.S., M.G., S.S., G.T., C.G., T.M.), Neuropathology (C.B., M.G.), and Medical Biometry and Epidemiology (K.W.), University Medical Center Hamburg-Eppendorf; and IME Screening Port (O.K., O.P.), Fraunhofer Institute for Molecular Biology and Applied Ecology, Hamburg, Germany.
Götz ThomallaDepartments of Immunology (V.T., R.H., M.K., E.T.), Neurology (V.T., S.S., M.G., S.S., G.T., C.G., T.M.), Neuropathology (C.B., M.G.), and Medical Biometry and Epidemiology (K.W.), University Medical Center Hamburg-Eppendorf; and IME Screening Port (O.K., O.P.), Fraunhofer Institute for Molecular Biology and Applied Ecology, Hamburg, Germany.
Oliver KeminerDepartments of Immunology (V.T., R.H., M.K., E.T.), Neurology (V.T., S.S., M.G., S.S., G.T., C.G., T.M.), Neuropathology (C.B., M.G.), and Medical Biometry and Epidemiology (K.W.), University Medical Center Hamburg-Eppendorf; and IME Screening Port (O.K., O.P.), Fraunhofer Institute for Molecular Biology and Applied Ecology, Hamburg, Germany.
Ole PleßDepartments of Immunology (V.T., R.H., M.K., E.T.), Neurology (V.T., S.S., M.G., S.S., G.T., C.G., T.M.), Neuropathology (C.B., M.G.), and Medical Biometry and Epidemiology (K.W.), University Medical Center Hamburg-Eppendorf; and IME Screening Port (O.K., O.P.), Fraunhofer Institute for Molecular Biology and Applied Ecology, Hamburg, Germany.
Christian BernreutherDepartments of Immunology (V.T., R.H., M.K., E.T.), Neurology (V.T., S.S., M.G., S.S., G.T., C.G., T.M.), Neuropathology (C.B., M.G.), and Medical Biometry and Epidemiology (K.W.), University Medical Center Hamburg-Eppendorf; and IME Screening Port (O.K., O.P.), Fraunhofer Institute for Molecular Biology and Applied Ecology, Hamburg, Germany.
Markus GlatzelDepartments of Immunology (V.T., R.H., M.K., E.T.), Neurology (V.T., S.S., M.G., S.S., G.T., C.G., T.M.), Neuropathology (C.B., M.G.), and Medical Biometry and Epidemiology (K.W.), University Medical Center Hamburg-Eppendorf; and IME Screening Port (O.K., O.P.), Fraunhofer Institute for Molecular Biology and Applied Ecology, Hamburg, Germany.
Karl WegscheiderDepartments of Immunology (V.T., R.H., M.K., E.T.), Neurology (V.T., S.S., M.G., S.S., G.T., C.G., T.M.), Neuropathology (C.B., M.G.), and Medical Biometry and Epidemiology (K.W.), University Medical Center Hamburg-Eppendorf; and IME Screening Port (O.K., O.P.), Fraunhofer Institute for Molecular Biology and Applied Ecology, Hamburg, Germany.
Christian GerloffDepartments of Immunology (V.T., R.H., M.K., E.T.), Neurology (V.T., S.S., M.G., S.S., G.T., C.G., T.M.), Neuropathology (C.B., M.G.), and Medical Biometry and Epidemiology (K.W.), University Medical Center Hamburg-Eppendorf; and IME Screening Port (O.K., O.P.), Fraunhofer Institute for Molecular Biology and Applied Ecology, Hamburg, Germany.
Tim MagnusDepartments of Immunology (V.T., R.H., M.K., E.T.), Neurology (V.T., S.S., M.G., S.S., G.T., C.G., T.M.), Neuropathology (C.B., M.G.), and Medical Biometry and Epidemiology (K.W.), University Medical Center Hamburg-Eppendorf; and IME Screening Port (O.K., O.P.), Fraunhofer Institute for Molecular Biology and Applied Ecology, Hamburg, Germany.
Eva TolosaDepartments of Immunology (V.T., R.H., M.K., E.T.), Neurology (V.T., S.S., M.G., S.S., G.T., C.G., T.M.), Neuropathology (C.B., M.G.), and Medical Biometry and Epidemiology (K.W.), University Medical Center Hamburg-Eppendorf; and IME Screening Port (O.K., O.P.), Fraunhofer Institute for Molecular Biology and Applied Ecology, Hamburg, Germany.
Universität Hamburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo explore the possibility of using interleukin-17 (IL-17) production by CD4+ T cells in the CSF as a potential biomarker for cerebral vasculitis in stroke patients.

methodsIn this consecutive case study, we performed prospective analysis of CSF and blood in patients admitted to a university medical center with symptoms of stroke and suspected cerebral vasculitis. Flow cytometry was performed for intracellular detection of inflammatory cytokines in peripheral blood lymphocytes and expanded T cells from CSF.

resultsCSF CD4+ lymphocytes from patients with cerebral vasculitis showed significantly higher levels of the proinflammatory cytokine IL-17 compared to patients with stroke not due to vasculitis or with other, noninflammatory neurologic diseases. There was no difference in the production of interferon-γ in the CSF and no overall differences in the relative frequencies of peripheral immune cells.

conclusionsIntracellular IL-17 in CSF cells is potentially useful in discriminating cerebral vasculitis as a rare cause in patients presenting with ischemic stroke. CLASSIFICATION OF EVIDENCE: This study provides Class II evidence that an increased proportion of IL-17-producing CD4+ cells in CSF of patients presenting with stroke symptoms is indicative of cerebral vasculitis (sensitivity 73%, 95% confidence interval [CI] 39-94%; specificity 100%, 95% CI 74%-100%).

Identifiers

PMID27144213
PMCPMC4841502
OpenAlexW2309534678

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