Evidence map›Paper›PMID 27144111›Full record

ArticleRespiratory medicine case reports2016

Pulmonary nocardiosis in Chronic Obstructive Pulmonary Disease: A new clinical challenge.

Giorgio Castellana, Anna Grimaldi, Marco Castellana, Claudio Farina, Giuseppe Castellana

Open access · goldAbstract readCase Reports
In one paragraph

Article in Respiratory medicine case reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
9.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Pulmonary Nocardiosis Presenting as Exacerbation of Chronic Pulmonary Disease.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2019
    Article
  8. Article
  9. Article
  10. BMJ case reports · 2019
    Article
  11. Disseminated nocardiosis in an immunocompetent patient.African journal of thoracic and critical care medicine · 2019
    Article
  12. Article
  13. Article
  14. Disseminated Infection ofJournal of cytology
    Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Giorgio CastellanaInstitute of Respiratory Disease, Aldo Moro University of Bari, Piazza Giulio Cesare 11, Bari, Italy.
Anna GrimaldiClinical Laboratory Medicine, P.O. "Di Venere-Triggiano", ASL Bari, Viale A. Moro, Triggiano, Bari, Italy.
Marco CastellanaAldo Moro University of Bari, Piazza Giulio Cesare 11, Bari, Italy.
Claudio FarinaMicrobiology Institute, AO "Papa Giovanni XXIII", Piazza OMS 1, Bergamo, Italy.
Giuseppe CastellanaDistrict Health Center, ASL Bari, Via Edmondo De Amicis 36, Conversano, Bari, Italy.
University of Bari Aldo Moro · ITOspedale Papa Giovanni XXIII · ITOspedale San Bassiano · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pulmonary nocardiosis (PN) is a rare but severe disease caused by Nocardia spp. Despite the traditional description as opportunistic infection, case reports and case series of pulmonary nocardiosis have recently been reported in immunocompetent patients too, in particular among people with chronic pulmonary diseases such as advanced Chronic Obstructive Pulmonary Disease (COPD). PN is characterized by non-specific symptoms and radiological findings; bacteriological culture can be difficult. For the reasons above, diagnosis of PN is challenging, sometimes resulting in a misdiagnosis of tuberculosis. We report an interesting case of PN in a 75-year-old male with COPD. He complained a 3-months history of fatigue, evening rise in body temperature, night sweats, unexplained weight loss of 5 kg, worsening dyspnea, cough and mucopurulent sputum. The chest X-ray showed multiple nodules with cavitations bilaterally in the apical and subclavian regions. Nocardia cyriacigeorgica with 100% identity was identified in three sputum samples. Since the patient has never undergone a systemic and/or inhaled steroid therapy, and has no respiratory failure and comorbidities entailing immunodepression, it is conceivable that, in this immunocompetent patient, the COPD could represent an isolated risk factor for PN. Risk factors, clinical presentations, radiographic findings, differential diagnosis and review of the literature of PN cases in COPD, pointing out the similarities and differences, are also described.

Indexed as

Chronic obstructive pulmonary diseaseChronic Obstructive Pulmonary Disease, COPDHigh Resolution Computed Tomography, HRCTHuman Immunodeficiency Virus, HIVOpportunistic infectionsPulmonary nocardiosisPulmonary Nocardiosis, PNtrimethoprim-sulfamethoxazole, TMP-SMXTuberculosisTuberculosis, TB

Identifiers

PMID27144111
PMCPMC4840429
OpenAlexW2296110887

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.