Evidence map›Paper›PMID 27144100›Full record

ArticleAdipocyte

A short bout of HFD promotes long-lasting hepatic lipid accumulation.

Fausto Chiazza, Tenagne D Challa, Fabrizio C Lucchini, Daniel Konrad, Stephan Wueest

Open access · goldAbstract read
In one paragraph

Article in Adipocyte. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.4field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
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  5. A macrophage-collagen fragment axis mediates subcutaneous adipose tissue remodeling in mice.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
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  10. Functional Effects of EPS-ProducingFrontiers in microbiology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 6 countries.

Fausto ChiazzaDivision of Pediatric Endocrinology and Diabetology; Zurich, Switzerland; Children's ResearchCenter; University Children's Hospital; Zurich, Switzerland; Department of Drug Science and Technology; University of Turin; Italy.
Tenagne D ChallaDivision of Pediatric Endocrinology and Diabetology; Zurich, Switzerland; Children's ResearchCenter; University Children's Hospital; Zurich, Switzerland.
Fabrizio C LucchiniDivision of Pediatric Endocrinology and Diabetology; Zurich, Switzerland; Children's ResearchCenter; University Children's Hospital; Zurich, Switzerland; ZurichCenter for Integrative Human Physiology; University of Zurich; Zurich, Switzerland.
Daniel KonradDivision of Pediatric Endocrinology and Diabetology; Zurich, Switzerland; Children's ResearchCenter; University Children's Hospital; Zurich, Switzerland; ZurichCenter for Integrative Human Physiology; University of Zurich; Zurich, Switzerland.
Stephan WueestDivision of Pediatric Endocrinology and Diabetology; Zurich, Switzerland; Children's ResearchCenter; University Children's Hospital; Zurich, Switzerland.
Uniwersytecki Szpital Dziecięcy · PLChildren's Clinical University Hospital · LVDiabetes Australia · AUPRG S&Tech (South Korea)

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A short bout of high fat diet (HFD) impairs glucose tolerance and induces hepatic steatosis in mice. Here, we aimed to elaborate on long-lasting effects of short-term high fat feeding. As expected, one week of HFD significantly impaired glucose tolerance. Intriguingly, recovery feeding with a standard rodent diet for 8 weeks did not fully normalize glucose tolerance. In addition, mice exposed to a short bout of HFD revealed significantly increased liver fat accumulation paralleled by elevated portal free fatty acid levels after 8 weeks of recovery feeding compared to exclusively chow-fed littermates. In conclusion, a short bout of HFD has long-lasting effects on hepatic lipid accumulation and glucose tolerance.

Indexed as

diabetes mellitusinsulin resistanceliverportal hypothesissteatosis

Identifiers

PMID27144100
PMCPMC4836456
OpenAlexW2262058213

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.