ArticleBacteriophage
Bacteriophage MS2 genomic RNA encodes an assembly instruction manual for its capsid.
Article in Bacteriophage. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 45 citations in OpenAlex.
- A reference genome without a virus: cDNA reconstruction reveals the provenance and function of the MS2 phage sequence.bioRxiv : the preprint server for biology · 2026Article
- Packaging of Single-Stranded RNA in Viruses and Virus-Like Particles.Annual review of biochemistry · 2026Review
- Many paths, similar destinations: viruses and bacterial microcompartments form polyhedra inside cells.Journal of virology · 2026Review
- Review
- Virucidal Efficacy of Organic Acids and Plant Essential Oils.Food and environmental virology · 2025Article
- Article
- Structure and proposed DNA delivery mechanism of a marine roseophage.Nature communications · 2023Article
- One-plasmid double-expression system for preparation of MS2 virus-like particles packaging SARS-CoV-2 RNA.Frontiers in cellular and infection microbiology · 2023Article
- Ribonucleocapsid assembly/packaging signals in the genomes of the coronaviruses SARS-CoV and SARS-CoV-2: detection, comparison and implications for therapeutic targeting.Journal of biomolecular structure & dynamics · 2022Article
- The diversity of protein-protein interaction interfaces within T=3 icosahedral viral capsids.Frontiers in molecular biosciences · 2022Article
- Advancements in protein nanoparticle vaccine platforms to combat infectious disease.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2021Review
- The importance of virion-incorporated cellular RNA-Binding Proteins in viral particle assembly and infectivity.Seminars in cell & developmental biology · 2021Review
- Machine-learning a virus assembly fitness landscape.PloS one · 2021Article
- Visualizing a viral genome with contrast variation small angle X-ray scattering.The Journal of biological chemistry · 2020Article
- Bacteriophage MS2 displays unreported capsid variability assembling T = 4 and mixed capsids.Molecular microbiology · 2020Article
- Investigating the Biological Relevance ofJournal of virology · 2019Article
- Targeting mechanisms of tailed bacteriophages.Nature reviews. Microbiology · 2018Review
- Preparation and Evaluation of Ribonuclease-Resistant Viral HIV RNA Standards Based on Armored RNA TechnologyIranian biomedical journal · 2018Article
- Intracellular RNA-tracking methods.Open biology · 2018Review
- Quantitative characterization of all single amino acid variants of a viral capsid-based drug delivery vehicle.Nature communications · 2018Article
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Authors and funding
14 authors at 3 institutions in 2 countries.
Funding
Abstract
Using RNA-coat protein crosslinking we have shown that the principal RNA recognition surface on the interior of infectious MS2 virions overlaps with the known peptides that bind the high affinity translational operator, TR, within the phage genome. The data also reveal the sequences of genomic fragments in contact with the coat protein shell. These show remarkable overlap with previous predictions based on the hypothesis that virion assembly is mediated by multiple sequences-specific contacts at RNA sites termed Packaging Signals (PSs). These PSs are variations on the TR stem-loop sequence and secondary structure. They act co-operatively to regulate the dominant assembly pathway and ensure cognate RNA encapsidation. In MS2, they also trigger conformational change in the dimeric capsomere creating the A/B quasi-conformer, 60 of which are needed to complete the
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.