ReviewNeural plasticity2016
The Contribution of Thalamocortical Core and Matrix Pathways to Sleep Spindles.
Review in Neural plasticity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 73 citations in OpenAlex.
- Trial
- Single-cell reconstruction of whole-brain efferent projections from mouse ventral posteromedial thalamus.Brain informatics · 2026Article
- Sleep Spindle Abnormalities in Preschool Children With Autism Spectrum Disability: Insights From Nap Polysomnography.Autism research : official journal of the International Society for Autism Research · 2025Article
- Increased Sleep Spindles in Regions Engaged during Motor Learning Predict Memory Consolidation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Neural Correlates of Huntington's Disease Based on Electroencephalography (EEG): A Mechanistic Review and Discussion of Excitation and Inhibition (E/I) Imbalance.Journal of clinical medicine · 2025Review
- The Cortical Structural Model Extends to Thalamocortical Connections.The European journal of neuroscience · 2025Article
- Differential expression of spatiotemporal sleep spindle clusters in aging.Sleep advances : a journal of the Sleep Research Society · 2025Article
- SPINDILOMETER: a model describing sleep spindles on EEG signals for polysomnography.Physical and engineering sciences in medicine · 2024Article
- Memory ability and retention performance relate differentially to sleep depth and spindle type.iScience · 2023Article
- Article
- Sleep spindles, stress and PTSD: The state of the science and future directions.Neurobiology of stress · 2023Article
- Sleep spindles in primates: Modeling the effects of distinct laminar thalamocortical connectivity in core, matrix, and reticular thalamic circuits.Network neuroscience (Cambridge, Mass.) · 2023Article
- Assessment of Cognitive Function with Sleep Spindle Characteristics in Adults with Epilepsy.Neural plasticity · 2023Article
- Relay and higher-order thalamic nuclei show an intertwined functional association with cortical-networks.Communications biology · 2022Article
- Article
- Pathways for Memory, Cognition and Emotional Context: Hippocampal, Subgenual Area 25, and Amygdalar Axons Show Unique Interactions in the Primate Thalamic Reuniens Nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- A Novel Approach to Estimating the Cortical Sources of Sleep Spindles Using Simultaneous EEG/MEG.Frontiers in neurology · 2022Article
- Cross-Frequency Slow Oscillation-Spindle Coupling in a Biophysically Realistic Thalamocortical Neural Mass Model.Frontiers in computational neuroscience · 2022Article
- Auditory stimulation during sleep suppresses spike activity in benign epilepsy with centrotemporal spikes.Cell reports. Medicine · 2021Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
Sleep spindles arise from the interaction of thalamic and cortical neurons. Neurons in the thalamic reticular nucleus (TRN) inhibit thalamocortical neurons, which in turn excite the TRN and cortical neurons. A fundamental principle of anatomical organization of the thalamocortical projections is the presence of two pathways: the diffuse matrix pathway and the spatially selective core pathway. Cortical layers are differentially targeted by these two pathways with matrix projections synapsing in superficial layers and core projections impinging on middle layers. Based on this anatomical observation, we propose that spindles can be classified into two classes, those arising from the core pathway and those arising from the matrix pathway, although this does not exclude the fact that some spindles might combine both pathways at the same time. We find evidence for this hypothesis in EEG/MEG studies, intracranial recordings, and computational models that incorporate this difference. This distinction will prove useful in accounting for the multiple functions attributed to spindles, in that spindles of different types might act on local and widespread spatial scales. Because spindle mechanisms are often hijacked in epilepsy and schizophrenia, the classification proposed in this review might provide valuable information in defining which pathways have gone awry in these neurological disorders.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.