Plastic Change along the Intact Crossed Pathway in Acute Phase of Cerebral Ischemia Revealed by Optical Intrinsic Signal Imaging.

Xiaoli Guo, Yongzhi He, Hongyang Lu, Yao Li, Xin Su, Ying Jiang, Shanbao Tong

Abstract read

In one paragraph

Article in Neural plasticity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Xiaoli GuoSchool of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.

Yongzhi HeSchool of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.

Hongyang LuSchool of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.

Yao LiSchool of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.

Xin SuSchool of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.

Ying JiangSchool of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.

Shanbao TongSchool of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The intact crossed pathway via which the contralesional hemisphere responds to the ipsilesional somatosensory input has shown to be affected by unilateral stroke. The aim of this study was to investigate the plasticity of the intact crossed pathway in response to different intensities of stimulation in a rodent photothrombotic stroke model. Using optical intrinsic signal imaging, an overall increase of the contralesional cortical response was observed in the acute phase (≤48 hours) after stroke. In particular, the contralesional hyperactivation is more prominent under weak stimulations, while a strong stimulation would even elicit a depressed response. The results suggest a distinct stimulation-response pattern along the intact crossed pathway after stroke. We speculate that the contralesional hyperactivation under weak stimulations was due to the reorganization for compensatory response to the weak ipsilateral somatosensory input.

Indexed as

AnimalsBrain IschemiaDisease Models, AnimalFunctional LateralityMaleNeuronal PlasticityOptical ImagingRatsRats, Sprague-DawleyStroke

Identifiers

PMID27144032

DOI10.1155/2016/1923160

PMCPMC4837289

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.