ArticleInternational journal of biological sciences2016
Ecological Trade-offs between Migration and Reproduction Are Mediated by the Nutrition-Sensitive Insulin-Signaling Pathway.
Article in International journal of biological sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 45 citations in OpenAlex.
- A single-cell atlas of alternative wing development in two hemipteran species.Nature communications · 2026Article
- The role of phenylalanine and tyrosine in longevity: a cohort and Mendelian randomization study.Aging · 2025Article
- The maternal vGluT2 and embryonic mGluR3 signaling relay system controls offspring wing dimorphism in pea aphid.iScience · 2025Article
- Energy Reserve Allocation in the Trade-Off between Migration and Reproduction in Fall Armyworm.Insects · 2024Article
- Article
- ChIP-seq profiling of H3K4me3 and H3K27me3 in an invasive insect,Frontiers in genetics · 2023Article
- The transcription factor Zfh1 acts as a wing-morph switch in planthoppers.Nature communications · 2022Article
- Fluctuating Asymmetry in the Polymorphic Sand Cricket (Insects · 2022Article
- Vestigial mediates the effect of insulin signaling pathway on wing-morph switching in planthoppers.PLoS genetics · 2021Article
- Association between host wing morphology polymorphism andEcology and evolution · 2020Article
- Sex-specific associations of insulin resistance with chronic kidney disease and kidney function: a bi-directional Mendelian randomisation study.Diabetologia · 2020Article
- Quantifying flight aptitude variation in wild Anopheles gambiae in order to identify long-distance migrants.Malaria journal · 2020Article
- Cell Cycle Progression Determines Wing Morph in the Polyphenic Insect Nilaparvata lugens.iScience · 2020Article
- Larval mannitol diets increase mortality, prolong development and decrease adult body sizes in fruit flies (Biology open · 2020Article
- Identification of genes underlying phenotypic plasticity of wing size via insulin signaling pathway by network-based analysis in Sogatella furcifera.BMC genomics · 2019Article
- Comparative transcriptomic analysis of a wing-dimorphic stonefly reveals candidate wing loss genes.EvoDevo · 2019Article
- Sex-specific Mendelian randomization study of genetically predicted insulin and cardiovascular events in the UK Biobank.Communications biology · 2019Article
- Integration of metabolomics and expression of enolase-phosphatase 1 links to hepatocellular carcinoma progression.Theranostics · 2019Article
- Genotyping-by-sequencing supports a genetic basis for wing reduction in an alpine New Zealand stonefly.Scientific reports · 2018Article
- Eco-evolutionary causes and consequences of temporal changes in intratumoural blood flow.Nature reviews. Cancer · 2018Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Crowding and changes in food availability are two critical environmental conditions that impact an animal's trajectory toward either migration or reproduction. Many insects facing this challenge have evolved wing polyphenisms. When conditions favor reproduction, wing polyphenic species produce adults that either have no wings or short, non-functional wings. Facultative wing growth reflects a physiological and evolutionary trade-off between migration and reproduction, triggered by environmental conditions. How environmental cues are transduced to produce these alternative forms, and their associated ecological shift from migration to reproduction, remains an important unsolved problem in evolutionary ecology. The brown planthopper, a wing polymorphic insect exhibiting strong trade-offs in investment between migration and reproduction, is one of the most serious rice pests in Asia. In this study, we investigated the function of four genes in the insulin-signaling pathway known to couple nutrition with growth, PI3 Kinase (PI3K), PDK1, Akt (Protein Kinase B), and the forkhead gene FOXO. Using a combination of RNA interference and pharmacological inhibitor treatment, we show that all four genes contribute to tissue level regulation of wing polymorphic development in this insect. As predicted, silencing of the NlPI3K, NlAkt and NlPDK1 through dsRNA and with the pharmacological inhibitor Perifosine resulted in short-winged brown planthoppers, whereas knockdown of NlFOXO resulted in long-winged planthoppers. Morphometric analyses confirm that phenotypes from our manipulations mimic what would be found in nature, i.e., major parameters such as bristle number, wing area and body weight are not significantly different from non-experimental animals. Taken together, these data implicate the insulin-signaling pathway in the transduction of environmental factors into condition-dependent patterns of wing growth in insects.
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