Evidence map›Paper›PMID 27143922›Full record

ArticleOncoTargets and therapy2016

Smad3 and phospho-Smad3 are potential markers of invasive nonfunctioning pituitary adenomas.

Chunhui Liu, Zhenye Li, Dan Wu, Chuzhong Li, Yazhuo Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in OncoTargets and therapy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Clinical and Pathological Aspects of Silent Pituitary Adenomas.The Journal of clinical endocrinology and metabolism · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Chunhui LiuBeijing Neurosurgical Institute, Capital Medical University, Beijing, People's Republic of China; Beijing Institute for Brain Disorders, Brain Tumor Center, Beijing, People's Republic of China.
Zhenye LiBeijing Neurosurgical Institute, Capital Medical University, Beijing, People's Republic of China; Beijing Institute for Brain Disorders, Brain Tumor Center, Beijing, People's Republic of China; Department of Neurosurgery, Beijing Tiantan hospital, Capital Medical University, Beijing, People's Republic of China.
Dan WuDepartment of Neurology, Beijing Renhe Hospital, Beijing, People's Republic of China.
Chuzhong LiBeijing Neurosurgical Institute, Capital Medical University, Beijing, People's Republic of China; Beijing Institute for Brain Disorders, Brain Tumor Center, Beijing, People's Republic of China; Department of Neurosurgery, Beijing Tiantan hospital, Capital Medical University, Beijing, People's Republic of China.
Yazhuo ZhangBeijing Neurosurgical Institute, Capital Medical University, Beijing, People's Republic of China; Beijing Institute for Brain Disorders, Brain Tumor Center, Beijing, People's Republic of China; Department of Neurosurgery, Beijing Tiantan hospital, Capital Medical University, Beijing, People's Republic of China.
Beijing Institute of Neurosurgery · CNBeijing Tian Tan Hospital · CNChinese Institute for Brain Research · CN

Funding

Prefrontal-Accumbens Glutamate and Ethanol Escalation in Adolescent and Adult C57R01AA020610 · NIAAA · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI MELENDEZ, ROBERTO I · 2014 to 2018
$1.8M
NIAAA NIH HHS R01 AA020610
6 · The paper itself

Abstract

backgroundTransforming growth factor-β (TGF-β) signaling plays important roles in tumor development. Nevertheless, the roles of TGF-β/Smad signaling in nonfunctioning pituitary adenomas (NFPAs) have not been fully studied.

methodsTumor samples were obtained from patients who had NFPAs and underwent endoscopic transsphenoidal surgery or craniotomy at Beijing Tiantan Hospital from March 2008 to December 2012. Immunohistochemistry was performed to determine the expression of Smad transducer proteins in NFPAs. Ki-67 was evaluated as an indicator of the proliferative activity of NFPAs.

resultsA total of 161 patients with NFPAs were identified; 59 (36.6%) had invasive NFPAs and 102 (63.4%) had noninvasive NFPAs. Protein levels of Smad3 and phospho-Smad3 (p-Smad3) were significantly lower in patients with invasive NFPAs than in patients with noninvasive NFPAs (P<0.05 and P<0.01, respectively). The Ki-67 index was markedly greater in invasive NFPAs than in noninvasive NFPAs (P<0.05) and was significant correlated with p-Smad3 levels (P<0.05, r=-0.702).

conclusionA low level of Smad3 and p-Smad3 proteins was associated with the invasion of NFPAs.

Indexed as

invasionKi-67nonfunctioning pituitary adenomaSmadtransforming growth factor-β

Identifiers

PMID27143922
PMCPMC4846076
OpenAlexW2338823688

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.