ArticleJournal of Indian Society of Periodontology
Periodontal pocket as a potential reservoir of high risk human papilloma virus: A pilot study.
Article in Journal of Indian Society of Periodontology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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Who cites it
6 citing papers in PubMed, 16 citations in OpenAlex.
- Role of viruses in periodontitis: An extensive review of herpesviruses, human immunodeficiency virus, coronavirus-19, papillomavirus and hepatitis viruses.World journal of virology · 2024Review
- Molecular Screening for High-Risk Human Papillomaviruses in Patients with Periodontitis.Viruses · 2023Article
- Investigation of the Relationship between Oral Human Papillomavirus Infection and Oral Health.Journal of dentistry (Shiraz, Iran) · 2022Article
- Is Human Papilloma Virus Infection Linked to Periodontitis? A Narrative Review.Current oral health reports · 2019Article
- Periodontitis and oral human papillomavirus infection among Hispanic adults.Papillomavirus research (Amsterdam, Netherlands) · 2018Article
- High HPV16 E6 viral load in the oral cavity is associated with an increased number of bacteria: A preliminary study.Biomedical reports · 2018Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimHuman papilloma viruses (HPVs) are small DNA viruses that have been identified in periodontal pocket as well as gingival sulcus. High risk HPVs are also associated with a subset of head and neck carcinomas. HPV detection in periodontium has previously involved DNA detection. This study attempts to: (a) Detect the presence or absence of high risk HPV in marginal periodontiun by identifying E6/E7 messenger RNA (mRNA) in cells from samples obtained by periodontal pocket scraping. (b) Detect the percentage of HPV E6/E7 mRNA in cells of pocket scrapings, which is responsible for producing oncoproteins E6 and E7. MATERIALS AND
methodsPocket scrapings from the periodontal pockets of eight subjects with generalized chronic periodontitis were taken the detection of presence or absence of E6, E7 mRNA was performed using in situ hybridization and flow cytometry.
resultsHPV E6/E7 mRNA was detected in four of the eight samples.
conclusionPresence of high risk human papillomaviruses in periodontal pockets patients of diagnosed with chronic periodontitis, not suffering from head and neck squamous cell carcinoma in the present day could link periodontitis to HPV related squamous cell carcinoma. Prevalence studies are needed detecting the presence of HPV in marginal periodontium as well as prospective studies of HPV positive periodontitis patients are required to explore this possible link.
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