Evidence map›Paper›PMID 27143646›Full record

ArticleScientific reports2016

Using Drosophila as an integrated model to study mild repetitive traumatic brain injury.

Ayeh Barekat, Arysa Gonzalez, Ruth E Mauntz, Roxanne W Kotzebue, Brandon Molina, Nadja El-Mecharrafie, Catherine J Conner, Shannon Garza, Girish C Melkani, William J Joiner and 3 more

Abstract read
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In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Review
  6. Quantitative genetics of trauma induced mortality inbioRxiv : the preprint server for biology · 2025
    Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. The Influence of Cannabinoids onCannabis and cannabinoid research · 2024
    Article
  12. Article
  13. TBI and Tau Loss of Function Both Affect Naïve Ethanol Sensitivity inInternational journal of molecular sciences · 2024
    Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ayeh BarekatDonald P. Shiley BioScience Center, San Diego State University, San Diego, CA, USA.
Arysa GonzalezDonald P. Shiley BioScience Center, San Diego State University, San Diego, CA, USA.
Ruth E MauntzDonald P. Shiley BioScience Center, San Diego State University, San Diego, CA, USA.
Roxanne W KotzebueDonald P. Shiley BioScience Center, San Diego State University, San Diego, CA, USA.
Brandon MolinaDonald P. Shiley BioScience Center, San Diego State University, San Diego, CA, USA.
Nadja El-MecharrafieDonald P. Shiley BioScience Center, San Diego State University, San Diego, CA, USA.
Catherine J ConnerDepartment of Biology, San Diego State University, San Diego, CA, USA.
Shannon GarzaDepartment of Biology, San Diego State University, San Diego, CA, USA.
Girish C MelkaniDepartment of Biology, San Diego State University, San Diego, CA, USA.
William J JoinerDepartment of Pharmacology, University of California San Diego, La Jolla, CA, USA.
Marta M LipinskiShock, Trauma, and Anesthesiology Research (STAR) Center; Department of Anesthesiology, University of Maryland School of Medicine, Baltimore, MD, USA.
Kim D FinleyDonald P. Shiley BioScience Center, San Diego State University, San Diego, CA, USA.
Eric P RatliffDonald P. Shiley BioScience Center, San Diego State University, San Diego, CA, USA.

Funding

Function and Mechanisms of Autophagy-Lysosomal Pathway in Traumatic Brain InjuryR01NS091218 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI LIPINSKI, MARTA M · 2015 to 2019
$1.8M
Age-dependent regulation of clearance and signaling pathwaysR01AG039628 · NIA · SAN DIEGO STATE UNIVERSITY · PI FINLEY, KIM D. · 2011 to 2015
$1.5M
NIA NIH HHS R01 AG039628NINDS NIH HHS R01 NS091218
6 · The paper itself

Abstract

Traumatic brain injury (TBI) is a major cause of morbidity and mortality worldwide. In addition, there has been a growing appreciation that even repetitive, milder forms of TBI (mTBI) can have long-term deleterious consequences to neural tissues. Hampering our understanding of genetic and environmental factors that influence the cellular and molecular responses to injury has been the limited availability of effective genetic model systems that could be used to identify the key genes and pathways that modulate both the acute and long-term responses to TBI. Here we report the development of a severe and mild-repetitive TBI model using Drosophila. Using this system, key features that are typically found in mammalian TBI models were also identified in flies, including the activation of inflammatory and autophagy responses, increased Tau phosphorylation and neuronal defects that impair sleep-related behaviors. This novel injury paradigm demonstrates the utility of Drosophila as an effective tool to validate genetic and environmental factors that influence the whole animal response to trauma and to identify prospective therapies needed for the treatment of TBI.

Indexed as

Disease Models, AnimalDrosophilaAnimalsBrain Injuries, Traumatic

Identifiers

PMID27143646
PMCPMC4855207

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.