ArticleNeurobiology of aging2016
The impact of aging, hearing loss, and body weight on mouse hippocampal redox state, measured in brain slices using fluorescence imaging.
Article in Neurobiology of aging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- Duration of Caloric Restriction Modulates Brain Redox Adaptation and Frailty During Aging.International journal of molecular sciences · 2026Article
- Age-related ultrastructural differences in the dorsal cortex of the inferior colliculus in the fischer brown Norway rat.Neurobiology of aging · 2026Article
- Auditory-limbic-cerebellum interactions and cognitive impairments in noise-induced hearing loss.CNS neuroscience & therapeutics · 2023Article
- Neuroprotective Effects ofAntioxidants (Basel, Switzerland) · 2022Article
- Amelioration of Age-Related Multiple Neuronal Impairments and Inflammation in High-Fat Diet-Fed Rats: The Prospective Multitargets of Geraniol.Oxidative medicine and cellular longevity · 2022Article
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- Sensory and memory processing in old female and male Wistar rat brain, and its relationship with the cortical and hippocampal redox state.GeroScience · 2021Article
- Does hearing loss lead to dementia? A review of the literature.Hearing research · 2021Review
- Inflammation and Insulin Resistance as Risk Factors and Potential Therapeutic Targets for Alzheimer's Disease.Frontiers in neuroscience · 2021Review
- Age-related murine hippocampal CA1 laminae oxidative stress measured in vivo by QUEnch-assiSTed (QUEST) MRI: impact of isoflurane anesthesia.GeroScience · 2020Article
- Aging and Central Auditory Disinhibition: Is It a Reflection of Homeostatic Downregulation or Metabolic Vulnerability?Brain sciences · 2019Review
- Article
- Piperlongumine decreases cognitive impairment and improves hippocampal function in aged mice.International journal of molecular medicine · 2018Article
- Article
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Authors and funding
4 authors at 1 institution in 1 country.
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Abstract
The relationships between oxidative stress in the hippocampus and other aging-related changes such as hearing loss, cortical thinning, or changes in body weight are not yet known. We measured the redox ratio in a number of neural structures in brain slices taken from young and aged mice. Hearing thresholds, body weight, and cortical thickness were also measured. We found striking aging-related increases in the redox ratio that were isolated to the stratum pyramidale, while such changes were not observed in thalamus or cortex. These changes were driven primarily by changes in flavin adenine dinucleotide, not nicotinamide adenine dinucleotide hydride. Multiple regression analysis suggested that neither hearing threshold nor cortical thickness independently contributed to this change in hippocampal redox ratio. However, body weight did independently contribute to predicted changes in hippocampal redox ratio. These data suggest that aging-related changes in hippocampal redox ratio are not a general reflection of overall brain oxidative state but are highly localized, while still being related to at least one marker of late aging, weight loss at the end of life.
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Registered trials
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