ArticleThe Journal of biological chemistry2016
Membranes as Structural Antioxidants: RECYCLING OF MALONDIALDEHYDE TO ITS SOURCE IN OXIDATION-SENSITIVE CHLOROPLAST FATTY ACIDS.
Article in The Journal of biological chemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 72 citations in OpenAlex.
- A hickory diacylglycerol acyltransferase gene coordinates fatty acid metabolism and aluminum tolerance in plants.The New phytologist · 2026Article
- Article
- Leaf Blight inPlants (Basel, Switzerland) · 2025Article
- Impact of gaseous ozone treatment of fish carcasses (Gadus morhua) on the microbiological load and their quality.PloS one · 2025Article
- Antiviral Activity of the Marine HaptophytaMarine drugs · 2024Article
- Processes independent of nonphotochemical quenching protect a high-light-tolerant desert alga from oxidative stress.Plant physiology · 2024Article
- AJournal of pharmaceutical analysis · 2023Article
- Effects of Hydrogen Peroxide on In Vitro Cultures of Tea (Molecules (Basel, Switzerland) · 2022Article
- Lipidomics-Assisted GWAS (lGWAS) Approach for Improving High-Temperature Stress Tolerance of Crops.International journal of molecular sciences · 2022Review
- Comparative transcriptomic analysis and antioxidant defense mechanisms in clusterbean (Cyamopsis tetragonoloba (L.) Taub.) genotypes with contrasting drought tolerance.Functional & integrative genomics · 2022Article
- New Insights into Xanthophylls and Lipidomic Profile Changes Induced by Glucose Supplementation in the Marine DiatomMarine drugs · 2022Article
- Effect of Temperature and Light Intensity on the Polar Lipidome of Endophytic Brown AlgaeMarine drugs · 2022Article
- Glyceroglycolipids in marine algae: A review of their pharmacological activity.Frontiers in pharmacology · 2022Review
- Characterization of Nannochloropsis oceanica Rose Bengal Mutants Sheds Light on Acclimation Mechanisms to High Light When Grown in Low Temperature.Plant & cell physiology · 2021Article
- Evaluation of physiological and biochemical responses of pistachio plants (Pistacia vera L.) exposed to pesticides.Ecotoxicology (London, England) · 2021Article
- Insights Into Walnut Lipid Metabolism From Metabolome and Transcriptome Analysis.Frontiers in genetics · 2021Article
- No Evidence for Trade-Offs Between Lifespan, Fecundity, and Basal Metabolic Rate Mediated by Liver Fatty Acid Composition in Birds.Frontiers in cell and developmental biology · 2021Article
- Ferroptosis in Ovarian Cancer: A Novel Therapeutic Strategy.Frontiers in oncology · 2021Review
- Physiological responses of plants and mites to salicylic acid improve the efficacy of spirodiclofen for controlling Tetranychus urticae (Acari: Tetranychidae) on greenhouse tomatoes.Experimental & applied acarology · 2020Article
- Citric Acid Assisted Phytoremediation of Chromium through Sunflower Plants Irrigated with Tannery Wastewater.Plants (Basel, Switzerland) · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genetic evidence suggests that membranes rich in polyunsaturated fatty acids (PUFAs) act as supramolecular antioxidants that capture reactive oxygen species, thereby limiting damage to proteins. This process generates lipid fragmentation products including malondialdehyde (MDA), an archetypal marker of PUFA oxidation. We observed transient increases in levels of endogenous MDA in wounded Arabidopsis thaliana leaves, raising the possibility that MDA is metabolized. We developed a rigorous ion exchange method to purify enzymatically generated (13)C- and (14)C-MDA. Delivered as a volatile to intact plants, MDA was efficiently incorporated into lipids. Mass spectral and genetic analyses identified the major chloroplast galactolipid: α-linolenic acid (18:3)-7Z,10Z,13Z-hexadecatrienoic acid (16:3)-monogalactosyldiacylglycerol (18:3-16:3-MGDG) as an end-product of MDA incorporation. Consistent with this, the fad3-2 fad7-2 fad8 mutant that lacks tri-unsaturated fatty acids incorporated (14)C-MDA into 18:2-16:2-MGDG. Saponification of (14)C-labeled 18:3-16:3-MGDG revealed 84% of (14)C-label in the acyl groups with the remaining 16% in the head group. 18:3-16:3-MGDG is enriched proximal to photosystem II and is likely a major in vivo source of MDA in photosynthetic tissues. We propose that nonenzymatically generated lipid fragments such as MDA are recycled back into plastidic galactolipids that, in their role as cell protectants, can again be fragmented into MDA.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.