ArticleJournal of Zhejiang University. Science. B2016
MACC1 upregulation promotes gastric cancer tumor cell metastasis and predicts a poor prognosis.
Article in Journal of Zhejiang University. Science. B, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 22 citations in OpenAlex.
- Identification and potential mechanism of a novel gastric cancer suppressor tRF-24-6VR8K09LE9.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- Prognostic risk stratification value of MACC1 expression in patients with gastric cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025Article
- Article
- Alpha-fetoprotein can promote gastric cancer progression via upregulation of metastasis-associated colon cancer 1.Oncology letters · 2022Article
- Association of MACC1 expression with lymphatic metastasis in colorectal cancer: A nested case-control study.PloS one · 2021Article
- Close interactions between lncRNAs, lipid metabolism and ferroptosis in cancer.International journal of biological sciences · 2021Review
- MACC1 and HGF are associated with survival in patients with gastric cancer.Oncology letters · 2018Article
- MACC1 facilitates chemoresistance and cancer stem cell‑like properties of colon cancer cells through the PI3K/AKT signaling pathway.Molecular medicine reports · 2017Article
- Article
- Long Noncoding RNA FGD5-AS1 Knockdown Decrease Viability, Migration, and Invasion of Non-Small Cell Lung Cancer (NSCLC) Cells by Regulating the MicroRNA-944/MACC1 Axis.Technology in cancer research & treatmentArticle
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
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Abstract
In various studies, metastasis associated with colon cancer 1 (MACC1) has been frequently reported to be abnormally highly expressed in human lung cancer, colon cancer, and hepatocellular carcinoma. Our study focuses on the association of MACC1 expression with gastric cancer (GC). During our experiment, the MACC1 expression was tested in 105 GC samples using an immunohistochemical (IHC) method. The clinical characteristics and prognosis of these patients were summarized. During analysis, MACC1 distribution in GC samples with distant metastasis was higher than that in normal samples and in tumors with no dissemination. Subsequently, a lower 5-year survival rate had a strong correlation with high MACC1 expression. As a consequence, the present results suggest that MACC1 is more frequently expressed in a poor prognosis phenotype of GC and acts as a promising prognostic prediction parameter for GC.
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