Evidence map›Paper›PMID 27142970›Full record

Trial reportDer Orthopade2016

What is the optimal approach for tranexamic acid application in patients with unilateral total hip arthroplasty?

Ying Zhang, Leilei Zhang, Xianghao Ma, Yudong Jia, Huichao Wang, Yingjie Zhu, Youwen Liu

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Der Orthopade, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
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  5. Review
  6. Article
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  9. Toxicity of tranexamic acid (TXA) to intra-articular tissue in orthopaedic surgery: a scoping review.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2021
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  18. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ying ZhangMedical Center of Hip, Luoyang Orthopedic Traumatology Hospital, No. 82, South Qiming Road, 471002, Henan, China.
Leilei ZhangMedical Center of Hip, Luoyang Orthopedic Traumatology Hospital, No. 82, South Qiming Road, 471002, Henan, China.
Xianghao MaMedical Center of Hip, Luoyang Orthopedic Traumatology Hospital, No. 82, South Qiming Road, 471002, Henan, China.
Yudong JiaMedical Center of Hip, Luoyang Orthopedic Traumatology Hospital, No. 82, South Qiming Road, 471002, Henan, China.
Huichao WangMedical Center of Hip, Luoyang Orthopedic Traumatology Hospital, No. 82, South Qiming Road, 471002, Henan, China.
Yingjie ZhuMedical Center of Hip, Luoyang Orthopedic Traumatology Hospital, No. 82, South Qiming Road, 471002, Henan, China.
Youwen LiuMedical Center of Hip, Luoyang Orthopedic Traumatology Hospital, No. 82, South Qiming Road, 471002, Henan, China. liuyouwenzhenggu@sina.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeIn the total hip arthroplasty (THA), the optimal administration route of tranexamic acid (TXA) remains controversial. This study was designed to investigate the impact of topical injection of TXA on blood loss during primary unilateral THA as well as short-term safety and adverse side effects compared with intravenous administration of TXA. MATERIAL AND

methodsIn this study, 75 patients who underwent unilateral THA were randomly divided into 3 groups receiving intra-articular TXA (IA group), intravenous TXA (IV group) or no TXA (control group C). Blood loss, postoperative drainage, covert blood loss, total blood volume, the number of blood transfusions after surgery and transfusion rate, incidence of deep venous thrombosis and pulmonary embolism were recorded and evaluated in the three groups after 1 week and 1 month.

resultsThere were significant differences in the quantity of postoperative drainage, covert blood loss, total blood volume, the number of blood transfusions after surgery and transfusion rates between the three groups (P < 0.05), but blood loss during surgery showed no significant differences among the three groups (P > 0.05). In the IV group, 1 patient suffered from deep venous thrombosis of the lower limbs and in the C group, 2 patients suffered from superficial venous thrombosis of the lower limbs 2 and 4 days after surgery, respectively. In the IA group no complications occurred during the follow-up period.

conclusionPreoperative intravenous TXA and postoperative topical TXA significantly reduced postoperative blood loss and transfusion rates among the patients who underwent primary unilateral THA and the short-term safety was good. The data suggest that topical injection of TXA is safer and more effective, without postoperative complications.

Indexed as

AdultAntifibrinolytic AgentsArthroplasty, Replacement, HipBlood Loss, SurgicalDose-Response Relationship, DrugDrug Administration ScheduleFemaleHumansMaleMiddle AgedOsteonecrosisPostoperative HemorrhageTranexamic AcidTreatment OutcomeAntifibrinolytic AgentsTranexamic AcidAdverse effectsOrthopedicsOsteonecrosis of the femoral headRandomized controlled studySafety

Identifiers

PMID27142970

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.