Evidence map›Paper›PMID 27142755›Full record

ArticleJournal of orthopaedic surgery and research2016

Scintigraphic evaluation of the osteoblastic activity of rabbit tibial defects after HYAFF11 membrane application.

Musa Uğur Mermerkaya, Mahmut Nedim Doral, Fatih Karaaslan, Gazi Huri, Seyhan Karacavuş, Burak Kaymaz, Erkan Alkan

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of orthopaedic surgery and research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Biodegradable materials for bone defect repair.Military Medical Research · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Musa Uğur MermerkayaDepartment of Orthopaedics and Traumatology, Medical School, Bozok University, Yozgat, Turkey. drugurmermerkaya@gmail.com.
Mahmut Nedim DoralDepartment of Orthopaedics and Traumatology, Medical School, Hacettepe University, Ankara, Turkey.
Fatih KaraaslanDepartment of Orthopaedics and Traumatology, Medical School, Bozok University, Yozgat, Turkey.
Gazi HuriDepartment of Orthopaedics and Traumatology, Medical School, Hacettepe University, Ankara, Turkey.
Seyhan KaracavuşDepartment of Nuclear Medicine, Medical School, Bozok University, Yozgat, Turkey.
Burak KaymazDepartment of Orthopaedics and Traumatology, Medical School, Çanakkale Onsekiz Mart University, Çanakkale, Turkey.
Erkan AlkanDepartment of Orthopaedics and Traumatology, Yalvaç State Hospital, Isparta, Turkey.
Bozok Universitesi · TRHacettepe University · TRÇanakkale Onsekiz Mart Üniversitesi · TRSivas State Hospital · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAn unfavorable condition for bone healing is the presence of bone defects. Under such conditions, a material can play a role to cover fractured or defective bone. Technological advances now allow for the use of such material. Hyalonect(®) (Fidia Advanced Biopolymers SLR, Italy), a novel membrane comprising knitted fibers of esterified hyaluronan (HYAFF11) can be used to cover fractured or grafted bone and can also serve as a scaffold to keep osteoprogenitor cells in place. The aim of this study was to compare osteoblastic activity by the use of scintigraphic methods in defective rabbit tibias during early-phase bone healing with or without a hyaluronan-based mesh.

methodsTwo groups (A and B) of New Zealand albino rabbits were used; each group included 10 animals. Operations on all rabbits were performed under general anesthesia. We also resected 10-mm bone segments from each animal's tibial diaphysis. After resection, tibias with defects were fixed using Kirschner wires. In group A, no hyaluronan-based mesh was used. In group B, tibial segmental defects were enclosed with a hyaluronan-based mesh. The rabbits were followed up for 4 weeks postoperatively, after which bone scintigraphic studies were performed on each animal to detect and compare osteoblastic activity.

resultsThe mean count in the fracture side of the hyaluronan-based mesh group was significantly higher compared to that of the group A (p = 0.019). However, there was no significant difference between group B and control rabbits with respect to the mean count on the intact bone side (p = 0.437). The bone defect (fracture)/intact bone mean count ratio was significantly higher in group B compared to group A (p = 0.008).

conclusionsA hyaluronan-based mesh plays a role in promoting osteoblastic activity. Hyalonect(®) is suitable for restoring tissue continuity whenever the periosteal membrane is structurally impaired or inadequate. Our results demonstrated that, during early-phase bone healing, osteoblastic activity was increased in bone defect sites when a hyaluronan-based mesh was also used. The most important aspect of this study concerns its scintigraphy-based design. This study is the first to use a scintigraphic method to demonstrate the effectiveness of hyaluronic acid-based material for bone healing.

Indexed as

AnimalsFracture HealingHyaluronic AcidMaleOsteoblastsRabbitsRadionuclide ImagingSurgical MeshTibiaTibial FracturesHyaluronic Acidhyaluronic acid benzyl esterBone healingBone scintigraphyHyaluronan-based meshOsteoblastic activity

Identifiers

PMID27142755
PMCPMC4855359
OpenAlexW2345578878

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.