ReviewNeuroscience bulletin2016
Molecular, Functional, and Structural Imaging of Major Depressive Disorder.
Review in Neuroscience bulletin, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 80 citations in OpenAlex.
- Neurocognitive Graphs of First-Episode Schizophrenia and Major Depression Based on Cognitive Features.Neuroscience bulletin · 2018Trial
- Abnormal gray matter volume and structural covariance network of basal ganglia-limbic system in patients with major depression disorder.Frontiers in neurology · 2025Article
- Progress in the application of molecular imaging in psychiatric disorders.Psychoradiology · 2023Article
- Evaluation of brain structure and metabolism in currently depressed adults with a history of childhood trauma.Translational psychiatry · 2022Article
- Returning to basic principles to develop more effective treatments for central nervous system disorders.Experimental biology and medicine (Maywood, N.J.) · 2022Article
- Volatile Organic Compounds From Breath Differ Between Patients With Major Depression and Healthy Controls.Frontiers in psychiatry · 2022Article
- Neural activity in adults with major depressive disorder differs from that in healthy individuals: A resting-state functional magnetic resonance imaging study.Frontiers in psychiatry · 2022Article
- Significance of Brain Glucose Hypometabolism, Altered Insulin Signal Transduction, and Insulin Resistance in Several Neurological Diseases.Frontiers in endocrinology · 2022Review
- Age-Related Decrease in Default-Mode Network Functional Connectivity Is Accelerated in Patients With Major Depressive Disorder.Frontiers in aging neuroscience · 2021Article
- Botulinum Neurotoxin Therapy for Depression: Therapeutic Mechanisms and Future Perspective.Frontiers in psychiatry · 2021Review
- Brain SPECT perfusion and PET metabolism as discordant biomarkers in major depressive disorder.EJNMMI research · 2020Article
- Psilocybin acutely alters the functional connectivity of the claustrum with brain networks that support perception, memory, and attention.NeuroImage · 2020Article
- Depression-Associated GeneCells · 2020Article
- Cortical Thickness in Dutch Police Officers: An Examination of Factors Associated with Resilience.Journal of traumatic stress · 2020Article
- Alleviation of Depression by Glucagon-Like Peptide 1 Through the Regulation of Neuroinflammation, Neurotransmitters, Neurogenesis, and Synaptic Function.Frontiers in pharmacology · 2020Review
- Testing the Mechanism of Action of Computerized Cognitive Training in Young Adults with Depression: Protocol for a Blinded, Randomized, Controlled Treatment Trial.Journal of psychiatry and brain science · 2020Article
- Physical Exercise and Neuroinflammation in Major Depressive Disorder.Molecular neurobiology · 2019Review
- Quantification of Tyrosine Hydroxylase and ErbB4 in the Locus Coeruleus of Mood Disorder Patients Using a Multispectral Method to Prevent Interference with Immunocytochemical Signals by Neuromelanin.Neuroscience bulletin · 2019Article
- Cognitive impairment in depression: recent advances and novel treatments.Neuropsychiatric disease and treatment · 2019Review
- Separate Neural Networks for Gains and Losses in Intertemporal Choice.Neuroscience bulletin · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Major depressive disorder (MDD) is a significant cause of morbidity and mortality worldwide, correlating with genetic susceptibility and environmental risk factors. Molecular, functional, and structural imaging approaches have been increasingly used to detect neurobiological changes, analyze neurochemical correlates, and parse pathophysiological mechanisms underlying MDD. We reviewed recent neuroimaging publications on MDD in terms of molecular, functional, and structural alterations as detected mainly by magnetic resonance imaging (MRI) and positron emission tomography. Altered structure and function of brain regions involved in the cognitive control of affective state have been demonstrated. An abnormal default mode network, as revealed by resting-state functional MRI, is likely associated with aberrant metabolic and serotonergic function revealed by radionuclide imaging. Further multi-modal investigations are essential to clarify the characteristics of the cortical network and serotonergic system associated with behavioral and genetic variations in MDD.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.