Evidence map›Paper›PMID 27142685›Full record

ArticleNeurobiology of disease2016

Delayed erythropoietin therapy improves histological and behavioral outcomes after transient neonatal stroke.

Amara Larpthaveesarp, Margaret Georgevits, Donna M Ferriero, Fernando F Gonzalez

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
16.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 54 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Amara LarpthaveesarpDepartment of Pediatrics, University of California San Francisco, San Francisco, CA 94143, United States.
Margaret GeorgevitsDepartment of Pediatrics, University of California San Francisco, San Francisco, CA 94143, United States.
Donna M FerrieroDepartment of Pediatrics, University of California San Francisco, San Francisco, CA 94143, United States; Department of Neurology, University of California San Francisco, San Francisco, CA 94143, United States.
Fernando F GonzalezDepartment of Pediatrics, University of California San Francisco, San Francisco, CA 94143, United States. Electronic address: Fernando.Gonzalez@ucsf.edu.
University of California, San Francisco · US

Funding

White matter injury as predictor of outcome in neonatal brain injuryP50NS035902 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIERO, DONNA M. · 1997 to 2012
$14.0M
Oxidant Mechanisms in Neonatal Brain InjuryR01NS033997 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIERO, DONNA M. · 1996 to 2016
$5.1M
Erythropoietin and Neurogenesis after Neonatal StrokeK08NS064094 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GONZALEZ, FERNANDO FRANCISCO · 2011 to 2015
$863k
NINDS NIH HHS K08 NS064094NINDS NIH HHS P50 NS035902NINDS NIH HHS R01 NS033997
6 · The paper itself

Abstract

background and purposeStroke is a major cause of neonatal morbidity, often with delayed diagnosis and with no accepted therapeutic options. The purpose of this study is to investigate the efficacy of delayed initiation of multiple dose erythropoietin (EPO) therapy in improving histological and behavioral outcomes after early transient ischemic stroke.

methods32 postnatal day 10 (P10) Sprague-Dawley rats underwent sham surgery or transient middle cerebral artery occlusion (tMCAO) for 3h, resulting in injury involving the striatum and parieto-temporal cortex. EPO (1000U/kg per dose×3 doses) or vehicle was administered intraperitoneally starting one week after tMCAO (at P17, P20, and P23). At four weeks after tMCAO, sensorimotor function was assessed in these four groups (6 vehicle-sham, 6 EPO-sham, 10 vehicle-tMCAO and 10 EPO-tMCAO) with forepaw preference in cylinder rearing trials. Brains were then harvested for hemispheric volume and Western blot analysis.

resultsEPO-tMCAO animals had significant improvement in forepaw symmetry in cylinder rearing trials compared to vehicle-tMCAO animals, and did not differ from sham animals. There was also significant preservation of hemispheric brain volume in EPO-tMCAO compared to vehicle-tMCAO animals. No differences in ongoing cell death at P17 or P24 were noted by spectrin cleavage in either EPO-tMCAO or vehicle-tMCAO groups.

conclusionsThese results suggest that delayed EPO therapy improves both behavioral and histological outcomes at one month following transient neonatal stroke, and may provide a late treatment alternative for early brain injury.

Indexed as

AnimalsAnimals, NewbornBrainBrain InjuriesCell DeathErythropoietinHypoxia-Ischemia, BrainInfarction, Middle Cerebral ArteryNeuronsRats, Sprague-DawleyStrokeErythropoietinBrain injuryErythropoietinIschemiaNeonatal strokeNeuroprotection

Identifiers

PMID27142685
PMCPMC4930700
OpenAlexW2344647123

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.