Evidence map›Paper›PMID 27142678›Full record

ArticleEuropean journal of human genetics : EJHG2016

Genetic variants in RBFOX3 are associated with sleep latency.

Najaf Amin, Karla V Allebrandt, Ashley van der Spek, Bertram Müller-Myhsok, Karin Hek, Maris Teder-Laving, Caroline Hayward, Tõnu Esko, Josine G van Mill, Hamdi Mbarek and 64 more

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Article in European journal of human genetics : EJHG, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  18. Genetic Influences on Evening Preference Overlap with Those for Bipolar Disorder in a Sample of Mexican Americans and American Indians.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2017
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

74 authors.

Najaf AminUnit of Genetic Epidemiology, Department of Epidemiology, Erasmus University Medical Centre, Rotterdam, The Netherlands.
Karla V AllebrandtInstitute of Medical Psychology, Ludwig-Maximilians-University, Munich, Germany.
Ashley van der SpekUnit of Genetic Epidemiology, Department of Epidemiology, Erasmus University Medical Centre, Rotterdam, The Netherlands.
Bertram Müller-MyhsokMax-Planck-Institute of Psychiatry, Munich, Germany.
Karin HekDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Maris Teder-LavingEstonian Genome Center, University of Tartu and Estonian Biocenter, Tartu, Estonia.
Caroline HaywardMedical Research Council, Human Genetics Unit, IGMM, University of Edinburgh, Edinburgh, Scotland.
Tõnu EskoEstonian Genome Center, University of Tartu and Estonian Biocenter, Tartu, Estonia.
Josine G van MillDepartment of Psychiatry, VU University Medical Center Amsterdam, Amsterdam, The Netherlands.
Hamdi MbarekDepartment of Biological Psychology, VU University, Amsterdam, The Netherlands.
Nathaniel F WatsonDepartment of Neurology, University of Washington, Seattle, WA, USA.
Scott A MelvilleDepartment of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA.
Fabiola M Del GrecoCenter for Biomedicine, European Academy of Bolzano, Bolzano, Italy - Affiliated Institute of the University of Lübeck, Lübeck, Germany.
Enda M ByrneQueensland Brain Institute, University of Queensland, Brisbane, QLD, Australia.
Edwin OoleCenter for Biomics, Erasmus Medical Center, Rotterdam, The Netherlands.
Ivana KolcicSchool of Medicine, University of Split, Split, Croatia.
Ting-Hsu ChenVA Boston Healthcare System, Boston University, Boston, MA, USA.
Daniel S EvansCalifornia Pacific Medical Center Research Institute, San Francisco, CA, USA.
Josef CoreshDepartments of Epidemiology, Biostatistics, and Medicine, Johns Hopkins University, Baltimore, MD, USA.
Nicole VogelzangsDepartment of Psychiatry, VU University Medical Center Amsterdam, Amsterdam, The Netherlands.
Juha KarjalainenDepartment of Genetics, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands.
Gonneke WillemsenDepartment of Biological Psychology, VU University, Amsterdam, The Netherlands.
Sina A GharibUniversity of Washington Medicine Sleep Center, Seattle, WA, USA.
Lina ZgagaMedical Research Council, Human Genetics Unit, IGMM, University of Edinburgh, Edinburgh, Scotland.
Evelin MihailovEstonian Genome Center, University of Tartu and Estonian Biocenter, Tartu, Estonia.
Katie L StoneCalifornia Pacific Medical Center Research Institute, San Francisco, CA, USA.
Harry CampbellCentre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland.
Rutger Ww BrouwerCenter for Biomics, Erasmus Medical Center, Rotterdam, The Netherlands.
Ayse DemirkanUnit of Genetic Epidemiology, Department of Epidemiology, Erasmus University Medical Centre, Rotterdam, The Netherlands.
Aaron IsaacsUnit of Genetic Epidemiology, Department of Epidemiology, Erasmus University Medical Centre, Rotterdam, The Netherlands.
Zoran DogasDepartment of Neuroscience and Sleep Medicine Centre, University of Split School of Medicine, Split, Croatia.
Kristin D MarcianteCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Susan CampbellMedical Research Council, Human Genetics Unit, IGMM, University of Edinburgh, Edinburgh, Scotland.
Fran BoroveckiCentre for Functional Genomics and Department of Neurology, Faculty of Medicine, University of Zagreb, Zagreb, Croatia.
Annemarie I LuikDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Man LiDepartment of Epidemiology, Johns Hopkins University, Baltimore, MD, USA.
Jouke Jan HottengaDepartment of Biological Psychology, VU University, Amsterdam, The Netherlands.
Jennifer E HuffmanMedical Research Council, Human Genetics Unit, IGMM, University of Edinburgh, Edinburgh, Scotland.
Mirjam Cgn van den HoutCenter for Biomics, Erasmus Medical Center, Rotterdam, The Netherlands.
Steven R CummingsCalifornia Pacific Medical Center Research Institute, San Francisco, CA, USA.
Yurii S AulchenkoUnit of Genetic Epidemiology, Department of Epidemiology, Erasmus University Medical Centre, Rotterdam, The Netherlands.
Philip R GehrmanDepartment of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA.
André G UitterlindenDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Heinz-Erich WichmannInstitute of Epidemiology I, Helmholtz Zentrum Munich-German Research Center for Environmental Health, Neuherberg, Germany.
Martina Müller-NurasyidInstitute of Epidemiology I, Helmholtz Zentrum Munich-German Research Center for Environmental Health, Neuherberg, Germany.
Rudolf Sn FehrmannDepartment of Genetics, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands.
Grant W MontgomeryQueensland Institute of Medical Research, Brisbane, QLD, Australia.
Albert HofmanDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Wen Hong Linda KaoDepartment of Epidemiology, Johns Hopkins University, Baltimore, MD, USA.
Ben A OostraUnit of Genetic Epidemiology, Department of Epidemiology, Erasmus University Medical Centre, Rotterdam, The Netherlands.
Alan F WrightMedical Research Council, Human Genetics Unit, IGMM, University of Edinburgh, Edinburgh, Scotland.
Jacqueline M VinkDepartment of Biological Psychology, VU University, Amsterdam, The Netherlands.
James F WilsonMedical Research Council, Human Genetics Unit, IGMM, University of Edinburgh, Edinburgh, Scotland.
Peter P PramstallerCenter for Biomedicine, European Academy of Bolzano, Bolzano, Italy - Affiliated Institute of the University of Lübeck, Lübeck, Germany.
Andrew A HicksCenter for Biomedicine, European Academy of Bolzano, Bolzano, Italy - Affiliated Institute of the University of Lübeck, Lübeck, Germany.
Ozren PolasekSchool of Medicine, University of Split, Split, Croatia.
Naresh M PunjabiDepartment of Pulmonary Medicine and Epidemiology, Johns Hopkins University, Baltimore, MD, USA.
Susan RedlineDepartment of Medicine, Brigham and Women's Hospital and Beth Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Bruce M PsatyCardiovascular Health Research Unit, Departments of Medicine, Epidemiology and Health Services, University of Washington, Seattle, WA, USA.
Andrew C HeathDepartment of Psychiatry, Washington University, St Louis, MO, USA.
Martha MerrowInstitute of Medical Psychology, Ludwig-Maximilians-University, Munich, Germany.
Gregory J TranahCalifornia Pacific Medical Center Research Institute, San Francisco, CA, USA.
Daniel J GottliebDepartment of Medicine, Brigham and Women's Hospital and Beth Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Dorret I BoomsmaDepartment of Biological Psychology, VU University, Amsterdam, The Netherlands.
Nicholas G MartinQueensland Institute of Medical Research, Brisbane, QLD, Australia.
Igor RudanCentre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland.
Henning TiemeierDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Wilfred Fj van IJckenCenter for Biomics, Erasmus Medical Center, Rotterdam, The Netherlands.
Brenda W PenninxDepartment of Psychiatry, VU University Medical Center Amsterdam, Amsterdam, The Netherlands.
Andres MetspaluEstonian Genome Center, University of Tartu and Estonian Biocenter, Tartu, Estonia.
Thomas MeitingerInstitute of Human Genetics, Helmholtz Zentrum München, Neuherberg, Germany.
Lude FrankeDepartment of Genetics, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands.
Till RoennebergInstitute of Medical Psychology, Ludwig-Maximilians-University, Munich, Germany.
Cornelia M van DuijnUnit of Genetic Epidemiology, Department of Epidemiology, Erasmus University Medical Centre, Rotterdam, The Netherlands.

Funding

CHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5M
Integrative Resource to Develop Translational Strategies to Promote LongevityU24AG051129 · NIA · CALIFORNIA PACIFIC MED CTR RES INSTITUTE · PI CUMMINGS, STEVEN RON, EVANS, DANIEL SPENCER · 2015 to 2019
$5.3M
Circadian rhythm genes and sleep disturbances in the elderlyR01AG030474 · NIA · CALIFORNIA PACIFIC MED CTR RES INSTITUTE · PI TRANAH, GREGORY J. · 2008 to 2010
$1.4M
Medical Research Council MC_PC_U127561128NHLBI NIH HHS R01 HL105756NIA NIH HHS R01 AG030474NIA NIH HHS U24 AG051129Parkinson's UK K-1206
6 · The paper itself

Abstract

Time to fall asleep (sleep latency) is a major determinant of sleep quality. Chronic, long sleep latency is a major characteristic of sleep-onset insomnia and/or delayed sleep phase syndrome. In this study we aimed to discover common polymorphisms that contribute to the genetics of sleep latency. We performed a meta-analysis of genome-wide association studies (GWAS) including 2 572 737 single nucleotide polymorphisms (SNPs) established in seven European cohorts including 4242 individuals. We found a cluster of three highly correlated variants (rs9900428, rs9907432 and rs7211029) in the RNA-binding protein fox-1 homolog 3 gene (RBFOX3) associated with sleep latency (P-values=5.77 × 10(-08), 6.59 × 10(-)(08) and 9.17 × 10(-)(08)). These SNPs were replicated in up to 12 independent populations including 30 377 individuals (P-values=1.5 × 10(-)(02), 7.0 × 10(-)(03) and 2.5 × 10(-)(03); combined meta-analysis P-values=5.5 × 10(-07), 5.4 × 10(-07) and 1.0 × 10(-07)). A functional prediction of RBFOX3 based on co-expression with other genes shows that this gene is predominantly expressed in brain (P-value=1.4 × 10(-316)) and the central nervous system (P-value=7.5 × 10(-)(321)). The predicted function of RBFOX3 based on co-expression analysis with other genes shows that this gene is significantly involved in the release cycle of neurotransmitters including gamma-aminobutyric acid and various monoamines (P-values<2.9 × 10(-11)) that are crucial in triggering the onset of sleep. To conclude, in this first large-scale GWAS of sleep latency we report a novel association of variants in RBFOX3 gene. Further, a functional prediction of RBFOX3 supports the involvement of RBFOX3 with sleep latency.

Indexed as

Polymorphism, Single NucleotideAntigens, NuclearBrainHumansNerve Tissue ProteinsSleepSynaptic TransmissionAntigens, NuclearNerve Tissue Proteinsneuronal nuclear antigen NeuN, human

Identifiers

PMID27142678
PMCPMC5027680

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