Evidence map›Paper›PMID 27142633›Full record

ArticleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2016

Oncologic and Perioperative Outcomes Following Selective Application of Laparoscopic Pancreaticoduodenectomy for Periampullary Malignancies.

Daniel Delitto, Casey M Luckhurst, Brian S Black, John L Beck, Thomas J George, George A Sarosi, Ryan M Thomas, Jose G Trevino, Kevin E Behrns, Steven J Hughes

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 13 pooled it
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 13 syntheses or guidelines pooled it, 74 citations in OpenAlex.

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  6. Laparoscopic PancreaticoduodenectomyFrontiers in oncology · 2021
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  16. Practice guidelines for managing extrahepatic biliary tract cancers.Annals of hepato-biliary-pancreatic surgery · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Daniel DelittoDepartment of Surgery, College of Medicine, University of Florida Health Science Center, Gainesville, FL, 32610, USA.
Casey M LuckhurstDepartment of Surgery, College of Medicine, University of Florida Health Science Center, Gainesville, FL, 32610, USA.
Brian S BlackDepartment of Surgery, College of Medicine, University of Florida Health Science Center, Gainesville, FL, 32610, USA.
John L BeckDepartment of Radiology, College of Medicine, University of Florida Health Science Center, Gainesville, FL, 32610, USA.
Thomas J GeorgeDepartment of Medicine, College of Medicine, University of Florida Health Science Center, Gainesville, FL, 32610, USA.
George A SarosiDepartment of Surgery, College of Medicine, University of Florida Health Science Center, Gainesville, FL, 32610, USA.
Ryan M ThomasDepartment of Surgery, College of Medicine, University of Florida Health Science Center, Gainesville, FL, 32610, USA.
Jose G TrevinoDepartment of Surgery, College of Medicine, University of Florida Health Science Center, Gainesville, FL, 32610, USA.
Kevin E BehrnsDepartment of Surgery, College of Medicine, University of Florida Health Science Center, Gainesville, FL, 32610, USA.
Steven J HughesDepartment of Surgery, College of Medicine, University of Florida Health Science Center, Gainesville, FL, 32610, USA. steven.hughes@surgery.ufl.edu.
University of Florida Health Science Center · USNorth Florida/South Georgia Veterans Health System · US

Funding

Surgical Oncology Research TrainingT32CA106493 · NCI · UNIVERSITY OF FLORIDA · PI BEHRNS, KEVIN E. · 2005 to 2014
$1.1M
NCI NIH HHS T32 CA106493
6 · The paper itself

Abstract

backgroundData are sparse regarding patient selection criteria or evaluating oncologic outcomes following laparoscopic pancreaticoduodenectomy (LPD). Having prospectively limited LPD to patients with resectable disease defined by National Comprehensive Cancer Network (NCCN) criteria, we evaluated perioperative and long-term oncologic outcomes of LPD compared to a similar cohort of open pancreaticoduodenectomy (OPD).

methodsConsecutive patients (November 2010-February 2014) undergoing pancreaticoduodenectomy (PD) for periampullary adenocarcinoma were reviewed. Patients were excluded from further analysis for benign pathology, conversion to OPD for portal vein resection, and contraindications for LPD not related to their malignancy. Outcomes of patients undergoing LPD were analyzed in an intention-to-treat manner against a cohort of patients undergoing OPD.

resultsThese selection criteria resulted in offering LPD to 77 % of all cancer patients. Compared to the OPD cohort, LPD was associated with significant reductions in wound infections (16 vs. 34 %; P = 0.038), pancreatic fistula (17 vs. 36 %; P = 0.032), and median hospital stay (9 vs. 12 days; P = 0.025). Overall survival (OS) was not statistically different between patients undergoing LPD vs. OPD for periampullary adenocarcinoma (median OS 27.9 vs. 23.5 months; P = 0.955) or pancreatic adenocarcinoma (N = 28 vs. 22 patients; median OS 20.7 vs. 21.1 months; P = 0.703).

conclusionsThe selective application of LPD for periampullary malignancies results in a high degree of eligibility as well as significant reductions in length of stay, wound infections, and pancreatic fistula. Overall survival after LPD is similar to OPD.

Indexed as

AdenocarcinomaAgedAmpulla of VaterBile Duct NeoplasmsCarcinoma, Pancreatic DuctalCholangiocarcinomaCommon Bile Duct NeoplasmsDuodenal NeoplasmsFemaleHumansLaparoscopyMaleMiddle AgedPancreaticoduodenectomyPatient SelectionRetrospective StudiesLaparoscopicLong-term outcomesMinimally invasiveOverall survivalPancreatic cancerPancreaticoduodenectomyPancreatic surgeryPeriampullary malignancy

Identifiers

PMID27142633
PMCPMC6033586
OpenAlexW2346020240

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.