ArticleScientific reports2016
Microgravity Induction of TRAIL Expression in Preosteoclast Cells Enhances Osteoclast Differentiation.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 33 citations in OpenAlex.
- Effects of microgravity mechanotransduction in bone tissue and cells: systematic review on primary cilium-dependent mechanisms.NPJ microgravity · 2026Article
- Review
- Exosomes from Microvascular Endothelial Cells under Mechanical Unloading Inhibit Osteogenic Differentiation via miR-92b-3p/ELK4 Axis.Journal of personalized medicine · 2022Article
- Tetrandrine inhibits RANKL-induced osteoclastogenesis by promoting the degradation of TRAIL.Molecular medicine (Cambridge, Mass.) · 2022Article
- Simulated Galactic Cosmic Rays Modify Mitochondrial Metabolism in Osteoclasts, Increase Osteoclastogenesis and Cause Trabecular Bone Loss in Mice.International journal of molecular sciences · 2021Article
- Osteoclasts and Microgravity.Life (Basel, Switzerland) · 2020Review
- The Influence of Radiation on Bone and Bone Cells-Differential Effects on Osteoclasts and Osteoblasts.International journal of molecular sciences · 2020Review
- Sclerostin expression in trabecular bone is downregulated by osteoclasts.Scientific reports · 2020Article
- Osteoclast Multinucleation: Review of Current Literature.International journal of molecular sciences · 2020Review
- Juglanin Inhibits Osteoclastogenesis in Ovariectomized Mice via the Suppression of NF-κB Signaling Pathways.Frontiers in pharmacology · 2020Article
- A novel method for bone fatigue monitoring and prediction.Bone reports · 2019Article
- Rapid Morphological and Cytoskeletal Response to Microgravity in Human Primary Macrophages.International journal of molecular sciences · 2019Article
- Gene Expression in Osteoblasts and Osteoclasts Under Microgravity Conditions: A Systematic Review.Current genomics · 2019Review
- Radix Paeoniae Rubra stimulates osteoclast differentiation by activation of the NF-κB and mitogen-activated protein kinase pathways.BMC complementary and alternative medicine · 2018Article
- Gene expression studies using a miniaturized thermal cycler system on board the International Space Station.PloS one · 2018Article
- Combined Effects of Simulated Microgravity and Radiation Exposure on Osteoclast Cell Fusion.International journal of molecular sciences · 2017Article
- Vitamin D Modulation of TRAIL Expression in Human Milk and Mammary Epithelial Cells.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Evidence indicates that astronauts experience significant bone loss in space. We previously showed that simulated microgravity (μXg) using the NASA developed rotary cell culture system (RCCS) enhanced bone resorbing osteoclast (OCL) differentiation. However, the mechanism by which μXg increases OCL formation is unclear. RANK/RANKL signaling pathway is critical for OCL differentiation. Tumor necrosis factor-related apoptosis inducing ligand (TRAIL) has been shown to increase osteoclastogenesis. We hypothesize that TRAIL may play an important role in μXg enhanced OCL differentiation. In this study, we identified by RT profiler PCR array screening that μXg induces high levels of TRAIL expression in murine preosteoclast cells in the absence of RANKL stimulation compared to ground based (Xg) cultures. We further identified that μXg elevated the adaptor protein TRAF-6 and fusion genes OC-STAMP and DC-STAMP expression in preosteoclast cells. Interestingly, neutralizing antibody against TRAIL significantly reduced μXg induced OCL formation. We further identified that over-expression of pTRAIL in RAW 264.7 cells enhanced OCL differentiation. These results indicate that TRAIL signaling plays an important role in the μXg increased OCL differentiation. Therefore, inhibition of TRAIL expression could be an effective countermeasure for μXg induced bone loss.
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