SynthesisJournal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale2016
The role of transoral robotic surgery, transoral laser microsurgery, and lingual tonsillectomy in the identification of head and neck squamous cell carcinoma of unknown primary origin: a systematic review.
Synthesis in Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 100 citations in OpenAlex.
- Occult squamous cell carcinoma presenting as oligometastatic lymphadenopathy. A systematic review with a case report.Oncology reviews · 2026Pooled it
- A systematic review on Transoral robotic surgery (TORS) for carcinoma of unknown primary origin: Has tongue base mucosectomy become indispensable?Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery · 2020Pooled it
- Article
- The Effectiveness of Tonsillectomy in the Diagnostic Workup of Squamous Cell Carcinoma Unknown Primary in the Head and Neck Based on p16 Immunohistochemistry.Medicina (Kaunas, Lithuania) · 2024Article
- Predictors for Success and Failure in Transoral Robotic Surgery-A Retrospective Study in the North of the Netherlands.Cancers · 2024Article
- The Role of Trans Oral Robotic Surgery in the Carcinoma of Unknown Primary: A New Evidence in the Horizon?Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2024Article
- Head and Neck Squamous Cell Carcinoma of Unknown Primary: A Diagnostic Work-Up.The oncologist · 2024Article
- Head and neck squamous cell carcinoma with heterotopic ossification, lymphovascular invasion, and nodal and pulmonary metastases in a 23-year-old Morgan gelding.The Canadian veterinary journal = La revue veterinaire canadienne · 2023Article
- Improved diagnostic accuracy of hybrid positron emission tomography (PET) with tumor-specific radiotracer for head and neck squamous cell carcinoma staging.Translational cancer research · 2023Article
- Transoral Robotic Surgery for Head and Neck Cancer: Advances and Residual Knowledge Gaps.Journal of clinical medicine · 2023Review
- Is There Room for Microsurgery in Robotic Surgery?Revista brasileira de ortopedia · 2022Article
- Intraoperative delineation of p16+ oropharyngeal carcinoma of unknown primary origin with fluorescence lifetime imaging: Preliminary report.Head & neck · 2022Article
- [Role of Robotic Surgery in ENT].Wiener medizinische Wochenschrift (1946) · 2022Article
- Cervical squamous cell carcinoma of unknown primary: Oncological outcomes and prognostic factors.Frontiers in oncology · 2022Article
- Transoral Robotic Surgery.Indian journal of surgical oncology · 2021Review
- Review
- Approach to the Patient with Unknown Primary Squamous Cell Carcinoma of the Head and Neck.Current treatment options in oncology · 2020Review
- Carcinoma of unknown primary detected by whole-body diffusion-weighted imaging: A case report and review of the literature.Radiology case reports · 2020Article
- Metastatic Squamous Cell Carcinoma to the Cervical Lymph Nodes From an Unknown Primary Cancer: Management in the HPV Era.Frontiers in oncology · 2020Review
- Supervised Autonomous Electrosurgery via Biocompatible Near-Infrared Tissue Tracking Techniques.IEEE transactions on medical robotics and bionics · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSquamous cell carcinoma of the head and neck can present as a cervical metastasis from an unknown primary site. Recently, transoral robotic surgery (TORS) and transoral laser microsurgery (TLM) have been incorporated in the workup of unknown primary tumors.
methodsWe searched MEDLINE, EMBASE, Cochrane, and CINAHL from inception to June 2015 for all English-language studies that utilized TORS, TLM, or lingual tonsillectomy in the approach to an unknown primary.
resultsOf 217 identified studies, eight were reviewed. TORS/TLM identified the primary tumor in 111/139 (80 %) patients overall, and 36/54 (67 %) patients with no remarkable findings following physical exam, radiologic imaging, and panendoscopy with directed biopsies. Lingual tonsillectomy identified the primary tumor in 18/25 (72 %) patients with no findings. Hemorrhage (5 %) was the most common perioperative complication.
conclusionLingual tonsillectomy using new approaches such as TORS/TLM may improve the identification of occult primary tumors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.