ArticleBiology open2016
Activation of PI3K signaling prevents aminoglycoside-induced hair cell death in the murine cochlea.
Article in Biology open, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 28 citations in OpenAlex.
- Effects of Insulin-Like Growth Factor (IGF-1) in Patients with Sensorineural Hearing Loss.The journal of international advanced otology · 2021Trial
- Zebrafish neuromast development: a target for endocrine disrupting chemicals?Frontiers in toxicology · 2026Article
- Comparative Cochlear Transcriptomics in Echolocating Bats and Mouse Reveals Hras as Protector Against Noise-Induced Hearing Loss.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- PTEN inhibitor bisperoxovanadium protects against noise-induced hearing loss.Neural regeneration research · 2023Article
- Rare-variant association analysis reveals known and new age-related hearing loss genes.European journal of human genetics : EJHG · 2023Article
- 6'-sialyllactose ameliorates the ototoxic effects of the aminoglycoside antibiotic neomycin in susceptible mice.Frontiers in immunology · 2023Article
- Article
- mTOR Signaling in the Inner Ear as Potential Target to Treat Hearing Loss.International journal of molecular sciences · 2021Review
- FGF20-FGFR1 signaling through MAPK and PI3K controls sensory progenitor differentiation in the organ of Corti.Developmental dynamics : an official publication of the American Association of Anatomists · 2021Article
- Key Signaling Pathways Regulate the Development and Survival of Auditory Hair Cells.Neural plasticity · 2021Review
- Single-Cell Fluorescence Analysis of Pseudotemporal Ordered Cells Provides Protein Expression Dynamics for Neuronal Differentiation.Frontiers in cell and developmental biology · 2019Article
- Tuberous sclerosis complex-mediated mTORC1 overactivation promotes age-related hearing loss.The Journal of clinical investigation · 2018Article
- Innovative pharmaceutical approaches for the management of inner ear disorders.Drug delivery and translational research · 2018Review
- Distinct effects on the dendritic arbor occur by microbead versus bath administration of brain-derived neurotrophic factor.Cellular and molecular life sciences : CMLS · 2017Article
- NEUROG1 Regulates CDK2 to Promote Proliferation in Otic Progenitors.Stem cell reports · 2017Article
- Activation of CHK1 in Supporting Cells Indirectly Promotes Hair Cell Survival.Frontiers in cellular neuroscience · 2017Article
- PI3K and Inhibitor of Apoptosis Proteins Modulate Gentamicin- Induced Hair Cell Death in the Zebrafish Lateral Line.Frontiers in cellular neuroscience · 2017Article
- Protein Synthesis Inhibition and Activation of the c-Jun N-Terminal Kinase Are Potential Contributors to Cisplatin Ototoxicity.Frontiers in cellular neuroscience · 2017Article
- Non-autonomous Cellular Responses to Ototoxic Drug-Induced Stress and Death.Frontiers in cellular neuroscience · 2017Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Loss of sensory hair cells of the inner ear due to aminoglycoside exposure is a major cause of hearing loss. Using an immortalized multipotent otic progenitor (iMOP) cell line, specific signaling pathways that promote otic cell survival were identified. Of the signaling pathways identified, the PI3K pathway emerged as a strong candidate for promoting hair cell survival. In aging animals, components for active PI3K signaling are present but decrease in hair cells. In this study, we determined whether activated PI3K signaling in hair cells promotes survival. To activate PI3K signaling in hair cells, we used a small molecule inhibitor of PTEN or genetically ablated PTEN using a conditional knockout animal. Hair cell survival was challenged by addition of gentamicin to cochlear cultures. Hair cells with activated PI3K signaling were more resistant to aminoglycoside-induced hair cell death. These results indicate that increased PI3K signaling in hair cells promote survival and the PI3K signaling pathway is a target for preventing aminoglycoside-induced hearing loss.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.