Evidence map›Paper›PMID 27142302›Full record

ReviewNutrition reviews2016

Reduced DHA transfer in diabetic pregnancies: mechanistic basis and long-term neurodevelopmental implications.

Michelle P Judge, Sharon G Casavant, Juliana A M Dias, Jacqueline M McGrath

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nutrition reviews, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Molecular pathways in placental-fetal development and disruption.Molecular and cellular endocrinology · 2024
    Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Michelle P JudgeM.P Judge, S.G. Casavant, J.A.M. Dias, and J.M. McGrath are with the University of Connecticut, School of Nursing, Storrs, Connecticut, USA. J.M. McGrath and S.G. Casavant are with the Connecticut Children's Medical Center, Hartford, Connecticut, USA.J.A.M. Dias is with the Nursing Department, Federal University of Ceará, Fortaleza Ceará, Brazil. michelle.judge@uconn.edu.
Sharon G CasavantM.P Judge, S.G. Casavant, J.A.M. Dias, and J.M. McGrath are with the University of Connecticut, School of Nursing, Storrs, Connecticut, USA. J.M. McGrath and S.G. Casavant are with the Connecticut Children's Medical Center, Hartford, Connecticut, USA.J.A.M. Dias is with the Nursing Department, Federal University of Ceará, Fortaleza Ceará, Brazil.
Juliana A M DiasM.P Judge, S.G. Casavant, J.A.M. Dias, and J.M. McGrath are with the University of Connecticut, School of Nursing, Storrs, Connecticut, USA. J.M. McGrath and S.G. Casavant are with the Connecticut Children's Medical Center, Hartford, Connecticut, USA.J.A.M. Dias is with the Nursing Department, Federal University of Ceará, Fortaleza Ceará, Brazil.
Jacqueline M McGrathM.P Judge, S.G. Casavant, J.A.M. Dias, and J.M. McGrath are with the University of Connecticut, School of Nursing, Storrs, Connecticut, USA. J.M. McGrath and S.G. Casavant are with the Connecticut Children's Medical Center, Hartford, Connecticut, USA.J.A.M. Dias is with the Nursing Department, Federal University of Ceará, Fortaleza Ceará, Brazil.
University of Connecticut · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Infants born to diabetic mothers have a higher frequency of impaired neurodevelopment. The omega-3 or n-3 fatty acid docosahexaenoic acid (DHA) is an important structural component of neural tissue and is critical for fetal brain development. Maternal DHA supplementation during pregnancy is linked to better infant neurodevelopment; however, maternal-fetal transfer of DHA is reduced in women with diabetes. Evidence of mechanisms explaining altered maternal-fetal DHA transfer in this population is limited. This review explores existing evidence underpinning reduced maternal-fetal DHA transfer in maternal fuel metabolism in this population. Further research is necessary to evaluate the role of peroxisome proliferator-activated receptors in modulating placental fatty acid binding and maternal-fetal DHA transfer. Considerations for clinical practice include a diet high in DHA and/or provision of supplemental DHA to obstetric diabetic patients within minimum guidelines.

Indexed as

Fetal DevelopmentMaternal-Fetal ExchangeBrainDiabetes MellitusDocosahexaenoic AcidsFemaleHumansNeuroprotective AgentsPlacentaPregnancyPregnancy in DiabeticsDocosahexaenoic AcidsNeuroprotective Agentsaltered omega-3 transferdiabetesinfant developmental outcomesomega-3 fatty acidsPPARpregestational type 2 diabetes.

Identifiers

PMID27142302
PMCPMC4892301
OpenAlexW2346508815

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.