Evidence map›Paper›PMID 27142103›Full record

ReviewChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2016

Consensus paper on post-operative pediatric cerebellar mutism syndrome: the Iceland Delphi results.

Thora Gudrunardottir, Angela T Morgan, Andrew L Lux, David A Walker, Karin S Walsh, Elizabeth M Wells, Jeffrey H Wisoff, Marianne Juhler, Jeremy D Schmahmann, Robert F Keating and 2 more

Abstract readReviewConsensus Statement
PubMed Publisher
In one paragraph

Review in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
100citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

100 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Association between cerebral perfusion and paediatric postoperative cerebellar mutism syndrome after posterior fossa surgery-a systematic review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021
    Pooled it
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  5. A CBF decrease in the left supplementary motor areas: New insight into postoperative pediatric cerebellar mutism syndrome using arterial spin labeling perfusion MRI.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021
    Trial
  6. Development and validation of a preoperative MRI-based predictive model for cerebellar mutism syndrome in pediatric posterior fossa tumors.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026
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  20. Glucocorticoid use in paediatric posterior fossa tumour surgery and the occurrence of postoperative speech impairment.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025
    Observational

40 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Thora GudrunardottirDepartment of Oncology and Palliation, North Zealand Hospital, Dyrehavevej 29, 3400, Hilleroed, Denmark. info@posteriorfossa.org.
Angela T MorganCentre for Neuroscience of Speech, University of Melbourne, Melbourne, Australia.
Andrew L LuxDepartment of Paediatric Neurology, Bristol Royal Hospital for Children, Bristol, UK.
David A WalkerDepartment of Oncology, Queen's Medical Centre, Nottingham, UK.
Karin S WalshDivision of Neuropsychology, Brain Tumor Institute, Neurofibromatosis Institute, Children's National Health System, Washington, DC, USA.
Elizabeth M WellsDivision of Neurology, Brain Tumor Institute, Children's National Health System, Washington, DC, USA.
Jeffrey H WisoffDivision of Pediatric Neurosurgery, New York University Langone Medical Center, New York, USA.
Marianne JuhlerDepartment of Neurosurgery, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Jeremy D SchmahmannDepartment of Neurology, Ataxia Unit, Cognitive Behavioral Neurology Unit, Laboratory for Neuroanatomy and Cerebellar Neurobiology, Massachusetts General Hospital, Boston, MA, USA.
Robert F KeatingDepartment of Pediatric Neurosurgery, Children's National Health System, Washington, DC, USA.
Coriene Catsman-BerrevoetsDepartment of Pediatric Neurology, Erasmus MC/Sophia Children's Hospital, Rotterdam, The Netherlands.
Iceland Delphi Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionConfusion has surrounded the description of post-operative mutism and associated morbidity in pediatric patients with cerebellar tumors for years. The heterogeneity of definitions and diagnostic features has hampered research progress within the field, and to date, no international guidelines exist on diagnosis, prevention, treatment, or follow-up of this debilitating condition. An international group of clinicians and researchers from multiple relevant disciplines recently formed a cohesive panel to formulate a new working definition and agree upon standardized methods for diagnosis and follow-up.

methodsConsensus was obtained using the modified nominal group technique, involving four rounds of online Delphi questionnaires interspersed with a structured consensus conference with lectures, group work, and open discussion sessions.

resultsA new, proposed definition of "post-operative pediatric CMS" was formed, preliminary recommendations for diagnostic and follow-up procedures were created, two working groups on a new scoring scale and risk prediction and prevention were established, and areas were identified where further information is needed. DISCUSSION: The consensus process was motivated by desire to further research and improve quality of life for pediatric brain tumor patients. The Delphi rounds identified relevant topics and established basic agreement, while face-to-face engagement helped resolve matters of conflict and refine terminology. The new definition is intended to provide a more solid foundation for future clinical and research work. It is thought as a consensus for moving forward and hopefully paves the way to developing a standard approach to this challenging problem with the advent of better scoring methods and ultimate goal of reducing the risk of CMS.

Indexed as

PediatricsCerebellar DiseasesDatabases, FactualHumansIcelandMutismPostoperative ComplicationsRisk FactorsSurveys and QuestionnairesCerebellar cognitive affective syndromeCerebellar mutismCerebellar tumor surgeryChildrenConsensusPosterior fossa syndrome

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.