ReviewNeurotoxicity research2016
Ototoxicity of Divalent Metals.
Review in Neurotoxicity research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 47 citations in OpenAlex.
- Environmental exposure to lead and cadmium and hearing loss in Chinese adults: A case-control study.PloS one · 2020Trial
- Salidroside in heavy metal toxicity: a mechanistic review of antioxidant, anti-inflammatory, and anti-apoptotic pathways.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026Review
- Peripheral and central auditory impairment linked to heavy metal exposure in Nicaraguan children from artisanal mining communities.Journal of global health · 2026Article
- Effects of polychlorinated biphenyls on the peripheral and central auditory systems.Hearing research · 2025Review
- Article
- Developmental cadmium exposure disrupts zebrafish vestibular calcium channels interfering with otolith formation and inner ear function.Neurotoxicology · 2023Article
- 2-Hydroxypropyl-β-cyclodextrin Ototoxicity in Adult Rats: Rapid Onset and Massive Destruction of Both Inner and Outer Hair Cells Above a Critical Dose.Neurotoxicity research · 2020Article
- Environmental Exposures and Hearing Loss.International journal of environmental research and public health · 2020Article
- Influence of In Vitro Electrical Stimulation on Survival of Spiral Ganglion Neurons.Neurotoxicity research · 2019Article
- Association between cadmium exposure and hearing impairment: a population-based study in Korean adults.Yeungnam University journal of medicine · 2019Article
- Auditory and Histopathological Effects of Topical Mercurochrome Treatment in Rats with Tympanic Membrane Perforation.The journal of international advanced otology · 2019Article
- Factors Associated With High Blood Lead Levels in a Sample of 100 Children in Tehran.Clinical medicine insights. Pediatrics · 2019Article
- Hearing loss, lead (Pb) exposure, and noise: a sound approach to ototoxicity exploration.Journal of toxicology and environmental health. Part B, Critical reviews · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Excess exposure to both essential and non-essential heavy metals can lead to a variety of adverse clinical conditions which selectively affect a variety of organs and cells in the body. The diverse, but highly specific nature of the symptoms produced by each metal indicates that they can interact with a restricted population of cellular targets ultimately resulting in unique clinical manifestations. The symptoms, which can be reversible or irreversible, often present with different patterns and outcomes depending on the net accumulated dose of any given metal. There are some common pathological conditions that result from excess exposure to heavy metals which unfortunately have not received widespread recognition and thus, have not been extensively investigated. For example, chronic exposure to several heavy metals such as Co, Mn, Cd, Pb, and Hg has the potential to affect hearing in humans and experimental animals based on previous studies including case reports and ex vivo studies. Understanding exactly how these metals induce hearing deficits is complicated by the fact that the inner ear is an extremely complex system that composed of a diverse collection of sensory, neural, and supporting cells which must act in synchrony to produce a neurophysiological signal terminating in the central auditory system. This review will focus on the anatomical, cellular, and functional changes that occur in the cochlea, the sensory organ for hearing, due to excessive exposure to manganese, cadmium, cobalt, lead, and mercury.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.