ArticleInternational journal of reproductive biomedicine2015
Serum levels of lycopene, beta-carotene, and retinol and their correlation with sperm DNA damage in normospermic and infertile men.
Article in International journal of reproductive biomedicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
11 citing papers in PubMed, 29 citations in OpenAlex.
- Dietary Lycopene Mitigates Reproductive Impairment in Heat-Stressed Rongchang Boars: Roles of Antioxidant, Anti-Inflammatory and Nrf2 Pathway.Antioxidants (Basel, Switzerland) · 2026Article
- Lycopene in male infertility.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- The role of diet and food supplements in infertility management in the Eastern Mediterranean Region: A narrative review.International journal of reproductive biomedicine · 2025Review
- Dietary Melatonin Boosts Reproduction and Growth Performance of Ornamental Fish Giant Danio (Aquaculture nutrition · 2025Article
- Joint and individual associations between multiple vitamins and sperm quality in adult men.Frontiers in nutrition · 2025Article
- Lycopene: A Potent Antioxidant with Multiple Health Benefits.Journal of nutrition and metabolism · 2024Review
- Neonatal vitamin A supplementation improves sheep fertility potential.Frontiers in veterinary science · 2024Article
- Lycopene as a Natural Antioxidant Used to Prevent Human Health Disorders.Antioxidants (Basel, Switzerland) · 2020Review
- Crocin Improves the Quality of Cryopreserved Goat Semen in Different Breeds.Animals : an open access journal from MDPI · 2020Article
- Water- and Fat-Soluble Antioxidants in Human Seminal Plasma and Serum of Fertile Males.Antioxidants (Basel, Switzerland) · 2019Article
- Association between seminal plasma neopterin and oxidative stress in male infertility: A case-control study.International journal of reproductive biomedicine · 2018Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOxidative stress in reproductive system leads to sperm DNA damage and sperm membrane lipid peroxidation and may play an important role in the pathogenesis of male infertility, especially in idiopathic cases. Antioxidants such as carotenoids function against free radical damages.
objectiveThe aim of this study was to determine the levels of lycopene, beta-carotene and retinol in serum and their relationship with sperm DNA damage and lipid peroxidation in infertile and normospermic males. MATERIALS AND
methodsSixty two infertile men and 71 normospermic men participated in this study. Blood and semen samples were collected from all subjects. Sperm DNA damage was measured using TUNEL method. Carotenoids, retinol, and malonedildehyde in serum were also determined.
resultsDNA fragmentation was higher in infertile group comparing to control group. Serum levels of lycopene, beta-carotene and, vitamin A in infertile men were significantly lower than normospermic men (p< 0.001, =0.005, and =0.003 respectively). While serum MDA was not significantly different between two groups, MDA in seminal plasma of infertile men was significantly higher than control group (p< 0.001).
conclusionWe concluded that lycopene, beta-carotene, and retinol can reduce sperm DNA fragmentation and lipid peroxidation through their antioxidant effect. Therefore the DNA fragmentation assay and determination of antioxidants factors such as lycopene, beta-carotene and retinol, along with sperm analysis can be useful in diagnosis and treatment of men with idiopathic infertility.
Indexed as
Identifiers
27141539PMC4827510W2275976442What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.