ArticleJournal of investigative medicine high impact case reports
Ectopic ACTH Production Leading to Diagnosis of Underlying Medullary Thyroid Carcinoma.
Article in Journal of investigative medicine high impact case reports. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- Management of ectopic Cushing syndrome in medullary thyroid carcinoma: from case reports to systematic literature review.Frontiers in endocrinology · 2026Pooled it
- Intestinal Perforation in ACTH-Dependent Cushing's Syndrome.BioMed research international · 2019Trial
- Article
- Adrenal incidentalomas, cortisol secretion and cancer: is there a real crosstalk?Frontiers in endocrinology · 2023Article
- Pharmacological management of severe Cushing's syndrome: the role of etomidate.Therapeutic advances in endocrinology and metabolism · 2022Review
- Metastatic medullary thyroid carcinoma presenting as ectopic Cushing's syndrome.Endocrinology, diabetes & metabolism case reports · 2021Article
- Multiple hormone secretion may indicate worse prognosis in patients with ectopic Cushing's syndrome.Hormones (Athens, Greece) · 2020Article
- Sporadic Medullary Thyroid Carcinoma with Paraneoplastic Cushing Syndrome.Case reports in endocrinology · 2019Article
- Ectopic Cushing Syndrome due to Metastatic Medullary Thyroid Cancer.AACE endocrinology and diabetesArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Medullary thyroid carcinoma (MTC) has been described as a source of ectopic ACTH secretion in patients with Cushing's syndrome. This is an infrequent association, occurring in less than 1% of MTC cases. Among these, it is even more unusual for an initial diagnosis of hypercortisolism to lead to the discovery of underlying MTC. Here we present a case of a patient with weakness, diarrhea, and hypokalemia who was found first to have Cushing's syndrome and later diagnosed with metastatic MTC. The patient was treated initially with oral agents to control his hypercortisolism, then with an etomidate infusion after experiencing intestinal perforation. He also received vandetanib therapy targeting his underlying malignancy, as this has been shown to reverse clinical signs of Cushing's syndrome in patients with MTC and subsequent ectopic ACTH secretion. Bilateral adrenalectomy was ultimately required. Medullary thyroid carcinoma should be considered in patients presenting with Cushing's syndrome due to ectopic ACTH secretion, and a multimodality treatment approach is often required.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.