Evidence map›Paper›PMID 27141339›Full record

ArticleOncoimmunology2016

PD-1 expression on dendritic cells suppresses CD8

Tong Seng Lim, Valerie Chew, Je Lin Sieow, Siting Goh, Joe Poh-Sheng Yeong, Ai Ling Soon, Paola Ricciardi-Castagnoli

Open access · goldAbstract read
In one paragraph

Article in Oncoimmunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 129 papers.

0numbers the graph read from it
0cells of the map it votes in
129citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

129 citing papers in PubMed, 178 citations in OpenAlex.

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  13. Myeloid cells in chronic liver inflammation.Cellular & molecular immunology · 2025
    Review
  14. Proteostasis of immune checkpoint receptors.The Biochemical journal · 2025
    Review
  15. Article
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69 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Tong Seng LimSingapore Immunology Network (SIgN), Agency for Science, Technology and Research (ASTAR), 8A Biomedical Grove, IMMUNOS Building #4, BIOPOLIS, Singapore; A. Menarini Biomarkers Singapore Pte Ltd, 30 Pasir Panjang Road, #08-32, Mapletree Business City, Singapore.
Valerie ChewSingHealth Translational Immunology and Inflammation Center (STIIC), Duke-NUS Medical School, The Academia , 20 College Road, Discovery Tower Level 8 , Singapore.
Je Lin SieowSingapore Immunology Network (SIgN), Agency for Science, Technology and Research (ASTAR) , 8A Biomedical Grove, IMMUNOS Building #4, BIOPOLIS , Singapore.
Siting GohSingapore Immunology Network (SIgN), Agency for Science, Technology and Research (ASTAR) , 8A Biomedical Grove, IMMUNOS Building #4, BIOPOLIS , Singapore.
Joe Poh-Sheng YeongSingapore Immunology Network (SIgN), Agency for Science, Technology and Research (ASTAR), 8A Biomedical Grove, IMMUNOS Building #4, BIOPOLIS, Singapore; Department of Pathology, Singapore General Hospital, 20 College Road, Academia, Diagnostics Tower, Singapore.
Ai Ling SoonSingapore Immunology Network (SIgN), Agency for Science, Technology and Research (ASTAR) , 8A Biomedical Grove, IMMUNOS Building #4, BIOPOLIS , Singapore.
Paola Ricciardi-CastagnoliGenomics, Genetics and Biology Innovation Pole (PoloGGB), Piazza Gambuli, Edificio D, 3° Piano, Perugia, Italy; A. Menarini Biomarkers Singapore Pte Ltd, 30 Pasir Panjang Road, #08-32, Mapletree Business City, Singapore.
Agency for Science, Technology and Research · SGDuke-NUS Medical School · SGPolo d’Innovazione di Genomica · ITSingapore General Hospital · SGSingapore Immunology Network · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Programmed death one (PD-1) is a well-established co-inhibitory regulator that suppresses proliferation and cytokine production of T cells. Despite remarkable progress in delineating the functional roles of PD-1 on T lymphocytes, little is known about the regulatory role of PD-1 expressed on myeloid cells such as dendritic cells (DCs). Here, we show that CD8

Indexed as

Antitumor immunitycancer immunotherapydendritic cellhepatocellular carcinomaliver cancerProgrammed death one (PD-1)

Identifiers

PMID27141339
PMCPMC4839350
OpenAlexW1962016368

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.