ArticleAvicenna journal of medical biotechnology
Distribution and Diversity of hmw1A Among Invasive Nontypeable Haemophilus influenzae Isolates in Iran.
Article in Avicenna journal of medical biotechnology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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Who cites it
3 citing papers in PubMed, 7 citations in OpenAlex.
- Immunization with HMW1 and HMW2 adhesins protects against colonization by heterologous strains of nontypeableProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Frequency of virulence-associated genotypes ofHeliyon · 2021Article
- Vaccine Candidates against Nontypeable Haemophilus influenzae: a ReviewIranian biomedical journal · 2017Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe pathogenesis of nontypeable Haemophilus influenzae (NTHi) begins with adhesion to the rhinopharyngeal mucosa. Almost 38-80% of NTHi clinical isolates produce proteins that belong to the High Molecular Weight (HMW) family of adhesins, which are believed to facilitate colonization.
methodsIn the present study, the prevalence of hmwA, which encodes the HMW adhesin, was determined for a collection of 32 NTHi isolates. Restriction Fragment Length Polymorphism (RFLP) was performed to advance our understanding of hmwA binding sequence diversity.
resultsThe results demonstrated that hmwA was detected in 61% of NTHi isolates. According to RFLP, isolates were divided into three groups.
conclusionBased on these observations, it is hypothesized that some strains of nontypeable Haemophilus influenzae infect some specific areas more than other parts.
Indexed as
Identifiers
27141269PMC4842248W2380287357What OpenQuestion holds
Registered trials
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