ArticleJournal of the National Cancer Institute2016
Elevated Bladder Cancer in Northern New England: The Role of Drinking Water and Arsenic.
Open access · bronzeAbstract readComparative Study
In one paragraph
Article in Journal of the National Cancer Institute, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed, 3 pooled it
16.3field-weighted citation impact, top 1% of its field
What it found
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The trial behind it
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Who cites it
78 citing papers in PubMed, 3 syntheses or guidelines pooled it, 149 citations in OpenAlex.
- Environmental Nonessential Element Exposure and Urologic Cancer: A Systematic Review and Meta-Analysis.JAMA network open · 2026Pooled it
- Use of study-specific MOE-like estimates to prioritize health effects from chemical exposure for analysis in human health assessments.Environment international · 2020Pooled it
- Systematic dose-response of environmental epidemiologic studies: Dose and response pre-analysis.Environment international · 2020Pooled it
- Associations between a mixture of trace elements and bladder cancer occurrence: A study of possible reverse causation.Environmental epidemiology (Philadelphia, Pa.) · 2026Article
- Pentachlorophenol enhances bladder cancer cell invasion through altered protein stability.iScience · 2026Article
- Not just splitting hairs-monitoring environmental chemical exposures, their biological effects and their social determinants with hair shafts and follicles: a narrative review.Environmental health : a global access science source · 2026Review
- The miR-125a-5p/IRF4 Axis Mediates Sodium Arsenite-Induced M2 Macrophage Polarization.Biomolecules · 2025Article
- Public Health Concerns at the Intersection of Drinking Water Contamination and Low Healthcare Access in Maine.Maine policy review · 2025Article
- pXRF Skeletal Measurements as an Assessment Tool for Environmental Exposure to Lajes Field-Derived Contaminants (Terceira Island, Azores, Portugal).Biological trace element research · 2025Article
- Lifetime water arsenic, genetic susceptibility, and bladder cancer in the New England Bladder Cancer Study.JNCI cancer spectrum · 2025Article
- Association of arsenic exposure with PDGF-BB in vitro and in a South Texas population exposed through drinking water.Toxicology and applied pharmacology · 2025Article
- Drinking water source and exposure to regulated water contaminants in the California Teachers Study cohort.Journal of exposure science & environmental epidemiology · 2025Article
- The modifying effect of dietary index for gut microbiota on the association between urinary arsenic exposure and bladder cancer risk: a nationwide cohort study.Frontiers in nutrition · 2025Article
- Education Fosters Action: Community Science Advances Arsenic Abatement in Maine and New Hampshire.Environmental health perspectives · 2024Article
- Quantified retrospective biomonitoring of fetal and infant elemental exposure using LA-ICP-MS analysis of deciduous dentin in three contrasting human cohorts.Journal of exposure science & environmental epidemiology · 2024Article
- A Mixed Methods Approach to Understanding the Public Health Impact of a School-Based Citizen Science Program to Reduce Arsenic in Private Well Water.Environmental health perspectives · 2024Article
- Risk Factors Associated with Urothelial Bladder Cancer.International journal of environmental research and public health · 2024Review
- Modeling Historic Arsenic Exposures and Spatial Risk for Bladder Cancer.Statistics in biosciences · 2024Article
- Epidemiology, Pattern, and Survival of Multiple Primary Malignant Neoplasms in Southeast Iran: Results of Kerman Population-Based Cancer Registry 2014-2020.Asian Pacific journal of cancer prevention : APJCP · 2024Article
- Association of Domestic Water Hardness with All-Cause and Cause-Specific Cancers: Evidence from 447,996 UK Biobank Participants.Environmental health perspectives · 2024Article
18 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
24 authors at 1 institution in 1 country.
Dalsu BarisDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD (DB [formerly], LEBF, JSC, MHW, NR, LEM, CS [formerly], RNH, JFF, DTS); Geisel School of Medicine at Dartmouth, Hanover, NH (RW, AS, MRK); Maine Cancer Registry, Augusta, ME (MS, CC [formerly]); US Geological Survey, Pembroke, NH (JA), Reston, VA (GR); Colorado State University, Fort Collins, CO (JN); Dartmouth College, Hanover, NH (BJ); Information Management Services, Calverton, MD (AT); New Hampshire State Cancer Registry, Concord, NH (GMH); New Hampshire State Occupational Surveillance Program, Concord, NH (KRA); Vermont Department of Health, Burlington, VT (RM, AJ). dalsubaris@gmail.com silvermd@mail.nih.gov.
Richard WaddellDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD (DB [formerly], LEBF, JSC, MHW, NR, LEM, CS [formerly], RNH, JFF, DTS); Geisel School of Medicine at Dartmouth, Hanover, NH (RW, AS, MRK); Maine Cancer Registry, Augusta, ME (MS, CC [formerly]); US Geological Survey, Pembroke, NH (JA), Reston, VA (GR); Colorado State University, Fort Collins, CO (JN); Dartmouth College, Hanover, NH (BJ); Information Management Services, Calverton, MD (AT); New Hampshire State Cancer Registry, Concord, NH (GMH); New Hampshire State Occupational Surveillance Program, Concord, NH (KRA); Vermont Department of Health, Burlington, VT (RM, AJ).
Laura E Beane FreemanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD (DB [formerly], LEBF, JSC, MHW, NR, LEM, CS [formerly], RNH, JFF, DTS); Geisel School of Medicine at Dartmouth, Hanover, NH (RW, AS, MRK); Maine Cancer Registry, Augusta, ME (MS, CC [formerly]); US Geological Survey, Pembroke, NH (JA), Reston, VA (GR); Colorado State University, Fort Collins, CO (JN); Dartmouth College, Hanover, NH (BJ); Information Management Services, Calverton, MD (AT); New Hampshire State Cancer Registry, Concord, NH (GMH); New Hampshire State Occupational Surveillance Program, Concord, NH (KRA); Vermont Department of Health, Burlington, VT (RM, AJ).
Molly SchwennDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD (DB [formerly], LEBF, JSC, MHW, NR, LEM, CS [formerly], RNH, JFF, DTS); Geisel School of Medicine at Dartmouth, Hanover, NH (RW, AS, MRK); Maine Cancer Registry, Augusta, ME (MS, CC [formerly]); US Geological Survey, Pembroke, NH (JA), Reston, VA (GR); Colorado State University, Fort Collins, CO (JN); Dartmouth College, Hanover, NH (BJ); Information Management Services, Calverton, MD (AT); New Hampshire State Cancer Registry, Concord, NH (GMH); New Hampshire State Occupational Surveillance Program, Concord, NH (KRA); Vermont Department of Health, Burlington, VT (RM, AJ).
Joanne S ColtDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD (DB [formerly], LEBF, JSC, MHW, NR, LEM, CS [formerly], RNH, JFF, DTS); Geisel School of Medicine at Dartmouth, Hanover, NH (RW, AS, MRK); Maine Cancer Registry, Augusta, ME (MS, CC [formerly]); US Geological Survey, Pembroke, NH (JA), Reston, VA (GR); Colorado State University, Fort Collins, CO (JN); Dartmouth College, Hanover, NH (BJ); Information Management Services, Calverton, MD (AT); New Hampshire State Cancer Registry, Concord, NH (GMH); New Hampshire State Occupational Surveillance Program, Concord, NH (KRA); Vermont Department of Health, Burlington, VT (RM, AJ).
Joseph D AyotteDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD (DB [formerly], LEBF, JSC, MHW, NR, LEM, CS [formerly], RNH, JFF, DTS); Geisel School of Medicine at Dartmouth, Hanover, NH (RW, AS, MRK); Maine Cancer Registry, Augusta, ME (MS, CC [formerly]); US Geological Survey, Pembroke, NH (JA), Reston, VA (GR); Colorado State University, Fort Collins, CO (JN); Dartmouth College, Hanover, NH (BJ); Information Management Services, Calverton, MD (AT); New Hampshire State Cancer Registry, Concord, NH (GMH); New Hampshire State Occupational Surveillance Program, Concord, NH (KRA); Vermont Department of Health, Burlington, VT (RM, AJ).
Mary H WardDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD (DB [formerly], LEBF, JSC, MHW, NR, LEM, CS [formerly], RNH, JFF, DTS); Geisel School of Medicine at Dartmouth, Hanover, NH (RW, AS, MRK); Maine Cancer Registry, Augusta, ME (MS, CC [formerly]); US Geological Survey, Pembroke, NH (JA), Reston, VA (GR); Colorado State University, Fort Collins, CO (JN); Dartmouth College, Hanover, NH (BJ); Information Management Services, Calverton, MD (AT); New Hampshire State Cancer Registry, Concord, NH (GMH); New Hampshire State Occupational Surveillance Program, Concord, NH (KRA); Vermont Department of Health, Burlington, VT (RM, AJ).
John NuckolsDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD (DB [formerly], LEBF, JSC, MHW, NR, LEM, CS [formerly], RNH, JFF, DTS); Geisel School of Medicine at Dartmouth, Hanover, NH (RW, AS, MRK); Maine Cancer Registry, Augusta, ME (MS, CC [formerly]); US Geological Survey, Pembroke, NH (JA), Reston, VA (GR); Colorado State University, Fort Collins, CO (JN); Dartmouth College, Hanover, NH (BJ); Information Management Services, Calverton, MD (AT); New Hampshire State Cancer Registry, Concord, NH (GMH); New Hampshire State Occupational Surveillance Program, Concord, NH (KRA); Vermont Department of Health, Burlington, VT (RM, AJ).
Alan SchnedDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD (DB [formerly], LEBF, JSC, MHW, NR, LEM, CS [formerly], RNH, JFF, DTS); Geisel School of Medicine at Dartmouth, Hanover, NH (RW, AS, MRK); Maine Cancer Registry, Augusta, ME (MS, CC [formerly]); US Geological Survey, Pembroke, NH (JA), Reston, VA (GR); Colorado State University, Fort Collins, CO (JN); Dartmouth College, Hanover, NH (BJ); Information Management Services, Calverton, MD (AT); New Hampshire State Cancer Registry, Concord, NH (GMH); New Hampshire State Occupational Surveillance Program, Concord, NH (KRA); Vermont Department of Health, Burlington, VT (RM, AJ).
Brian JacksonDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD (DB [formerly], LEBF, JSC, MHW, NR, LEM, CS [formerly], RNH, JFF, DTS); Geisel School of Medicine at Dartmouth, Hanover, NH (RW, AS, MRK); Maine Cancer Registry, Augusta, ME (MS, CC [formerly]); US Geological Survey, Pembroke, NH (JA), Reston, VA (GR); Colorado State University, Fort Collins, CO (JN); Dartmouth College, Hanover, NH (BJ); Information Management Services, Calverton, MD (AT); New Hampshire State Cancer Registry, Concord, NH (GMH); New Hampshire State Occupational Surveillance Program, Concord, NH (KRA); Vermont Department of Health, Burlington, VT (RM, AJ).
Castine ClerkinDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD (DB [formerly], LEBF, JSC, MHW, NR, LEM, CS [formerly], RNH, JFF, DTS); Geisel School of Medicine at Dartmouth, Hanover, NH (RW, AS, MRK); Maine Cancer Registry, Augusta, ME (MS, CC [formerly]); US Geological Survey, Pembroke, NH (JA), Reston, VA (GR); Colorado State University, Fort Collins, CO (JN); Dartmouth College, Hanover, NH (BJ); Information Management Services, Calverton, MD (AT); New Hampshire State Cancer Registry, Concord, NH (GMH); New Hampshire State Occupational Surveillance Program, Concord, NH (KRA); Vermont Department of Health, Burlington, VT (RM, AJ).
Nathaniel RothmanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD (DB [formerly], LEBF, JSC, MHW, NR, LEM, CS [formerly], RNH, JFF, DTS); Geisel School of Medicine at Dartmouth, Hanover, NH (RW, AS, MRK); Maine Cancer Registry, Augusta, ME (MS, CC [formerly]); US Geological Survey, Pembroke, NH (JA), Reston, VA (GR); Colorado State University, Fort Collins, CO (JN); Dartmouth College, Hanover, NH (BJ); Information Management Services, Calverton, MD (AT); New Hampshire State Cancer Registry, Concord, NH (GMH); New Hampshire State Occupational Surveillance Program, Concord, NH (KRA); Vermont Department of Health, Burlington, VT (RM, AJ).
Lee E MooreDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD (DB [formerly], LEBF, JSC, MHW, NR, LEM, CS [formerly], RNH, JFF, DTS); Geisel School of Medicine at Dartmouth, Hanover, NH (RW, AS, MRK); Maine Cancer Registry, Augusta, ME (MS, CC [formerly]); US Geological Survey, Pembroke, NH (JA), Reston, VA (GR); Colorado State University, Fort Collins, CO (JN); Dartmouth College, Hanover, NH (BJ); Information Management Services, Calverton, MD (AT); New Hampshire State Cancer Registry, Concord, NH (GMH); New Hampshire State Occupational Surveillance Program, Concord, NH (KRA); Vermont Department of Health, Burlington, VT (RM, AJ).
Anne TaylorDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD (DB [formerly], LEBF, JSC, MHW, NR, LEM, CS [formerly], RNH, JFF, DTS); Geisel School of Medicine at Dartmouth, Hanover, NH (RW, AS, MRK); Maine Cancer Registry, Augusta, ME (MS, CC [formerly]); US Geological Survey, Pembroke, NH (JA), Reston, VA (GR); Colorado State University, Fort Collins, CO (JN); Dartmouth College, Hanover, NH (BJ); Information Management Services, Calverton, MD (AT); New Hampshire State Cancer Registry, Concord, NH (GMH); New Hampshire State Occupational Surveillance Program, Concord, NH (KRA); Vermont Department of Health, Burlington, VT (RM, AJ).
Gilpin RobinsonDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD (DB [formerly], LEBF, JSC, MHW, NR, LEM, CS [formerly], RNH, JFF, DTS); Geisel School of Medicine at Dartmouth, Hanover, NH (RW, AS, MRK); Maine Cancer Registry, Augusta, ME (MS, CC [formerly]); US Geological Survey, Pembroke, NH (JA), Reston, VA (GR); Colorado State University, Fort Collins, CO (JN); Dartmouth College, Hanover, NH (BJ); Information Management Services, Calverton, MD (AT); New Hampshire State Cancer Registry, Concord, NH (GMH); New Hampshire State Occupational Surveillance Program, Concord, NH (KRA); Vermont Department of Health, Burlington, VT (RM, AJ).
Gm Monawar HosainDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD (DB [formerly], LEBF, JSC, MHW, NR, LEM, CS [formerly], RNH, JFF, DTS); Geisel School of Medicine at Dartmouth, Hanover, NH (RW, AS, MRK); Maine Cancer Registry, Augusta, ME (MS, CC [formerly]); US Geological Survey, Pembroke, NH (JA), Reston, VA (GR); Colorado State University, Fort Collins, CO (JN); Dartmouth College, Hanover, NH (BJ); Information Management Services, Calverton, MD (AT); New Hampshire State Cancer Registry, Concord, NH (GMH); New Hampshire State Occupational Surveillance Program, Concord, NH (KRA); Vermont Department of Health, Burlington, VT (RM, AJ).
Karla R ArmentiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD (DB [formerly], LEBF, JSC, MHW, NR, LEM, CS [formerly], RNH, JFF, DTS); Geisel School of Medicine at Dartmouth, Hanover, NH (RW, AS, MRK); Maine Cancer Registry, Augusta, ME (MS, CC [formerly]); US Geological Survey, Pembroke, NH (JA), Reston, VA (GR); Colorado State University, Fort Collins, CO (JN); Dartmouth College, Hanover, NH (BJ); Information Management Services, Calverton, MD (AT); New Hampshire State Cancer Registry, Concord, NH (GMH); New Hampshire State Occupational Surveillance Program, Concord, NH (KRA); Vermont Department of Health, Burlington, VT (RM, AJ).
Richard McCoyDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD (DB [formerly], LEBF, JSC, MHW, NR, LEM, CS [formerly], RNH, JFF, DTS); Geisel School of Medicine at Dartmouth, Hanover, NH (RW, AS, MRK); Maine Cancer Registry, Augusta, ME (MS, CC [formerly]); US Geological Survey, Pembroke, NH (JA), Reston, VA (GR); Colorado State University, Fort Collins, CO (JN); Dartmouth College, Hanover, NH (BJ); Information Management Services, Calverton, MD (AT); New Hampshire State Cancer Registry, Concord, NH (GMH); New Hampshire State Occupational Surveillance Program, Concord, NH (KRA); Vermont Department of Health, Burlington, VT (RM, AJ).
Claudine SamanicDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD (DB [formerly], LEBF, JSC, MHW, NR, LEM, CS [formerly], RNH, JFF, DTS); Geisel School of Medicine at Dartmouth, Hanover, NH (RW, AS, MRK); Maine Cancer Registry, Augusta, ME (MS, CC [formerly]); US Geological Survey, Pembroke, NH (JA), Reston, VA (GR); Colorado State University, Fort Collins, CO (JN); Dartmouth College, Hanover, NH (BJ); Information Management Services, Calverton, MD (AT); New Hampshire State Cancer Registry, Concord, NH (GMH); New Hampshire State Occupational Surveillance Program, Concord, NH (KRA); Vermont Department of Health, Burlington, VT (RM, AJ).
Robert N HooverDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD (DB [formerly], LEBF, JSC, MHW, NR, LEM, CS [formerly], RNH, JFF, DTS); Geisel School of Medicine at Dartmouth, Hanover, NH (RW, AS, MRK); Maine Cancer Registry, Augusta, ME (MS, CC [formerly]); US Geological Survey, Pembroke, NH (JA), Reston, VA (GR); Colorado State University, Fort Collins, CO (JN); Dartmouth College, Hanover, NH (BJ); Information Management Services, Calverton, MD (AT); New Hampshire State Cancer Registry, Concord, NH (GMH); New Hampshire State Occupational Surveillance Program, Concord, NH (KRA); Vermont Department of Health, Burlington, VT (RM, AJ).
Joseph F FraumeniDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD (DB [formerly], LEBF, JSC, MHW, NR, LEM, CS [formerly], RNH, JFF, DTS); Geisel School of Medicine at Dartmouth, Hanover, NH (RW, AS, MRK); Maine Cancer Registry, Augusta, ME (MS, CC [formerly]); US Geological Survey, Pembroke, NH (JA), Reston, VA (GR); Colorado State University, Fort Collins, CO (JN); Dartmouth College, Hanover, NH (BJ); Information Management Services, Calverton, MD (AT); New Hampshire State Cancer Registry, Concord, NH (GMH); New Hampshire State Occupational Surveillance Program, Concord, NH (KRA); Vermont Department of Health, Burlington, VT (RM, AJ).
Alison JohnsonDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD (DB [formerly], LEBF, JSC, MHW, NR, LEM, CS [formerly], RNH, JFF, DTS); Geisel School of Medicine at Dartmouth, Hanover, NH (RW, AS, MRK); Maine Cancer Registry, Augusta, ME (MS, CC [formerly]); US Geological Survey, Pembroke, NH (JA), Reston, VA (GR); Colorado State University, Fort Collins, CO (JN); Dartmouth College, Hanover, NH (BJ); Information Management Services, Calverton, MD (AT); New Hampshire State Cancer Registry, Concord, NH (GMH); New Hampshire State Occupational Surveillance Program, Concord, NH (KRA); Vermont Department of Health, Burlington, VT (RM, AJ).
Margaret R KaragasDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD (DB [formerly], LEBF, JSC, MHW, NR, LEM, CS [formerly], RNH, JFF, DTS); Geisel School of Medicine at Dartmouth, Hanover, NH (RW, AS, MRK); Maine Cancer Registry, Augusta, ME (MS, CC [formerly]); US Geological Survey, Pembroke, NH (JA), Reston, VA (GR); Colorado State University, Fort Collins, CO (JN); Dartmouth College, Hanover, NH (BJ); Information Management Services, Calverton, MD (AT); New Hampshire State Cancer Registry, Concord, NH (GMH); New Hampshire State Occupational Surveillance Program, Concord, NH (KRA); Vermont Department of Health, Burlington, VT (RM, AJ).
Debra T SilvermanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD (DB [formerly], LEBF, JSC, MHW, NR, LEM, CS [formerly], RNH, JFF, DTS); Geisel School of Medicine at Dartmouth, Hanover, NH (RW, AS, MRK); Maine Cancer Registry, Augusta, ME (MS, CC [formerly]); US Geological Survey, Pembroke, NH (JA), Reston, VA (GR); Colorado State University, Fort Collins, CO (JN); Dartmouth College, Hanover, NH (BJ); Information Management Services, Calverton, MD (AT); New Hampshire State Cancer Registry, Concord, NH (GMH); New Hampshire State Occupational Surveillance Program, Concord, NH (KRA); Vermont Department of Health, Burlington, VT (RM, AJ). dalsubaris@gmail.com silvermd@mail.nih.gov.
National Cancer Institute · US
Funding
Cancer Risk and Environmental ExposuresZIACP010125 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI PURDUE, MARK · 2009 to 2025
$41.3MCLINICAL/IMMUNOLOGIC/GENETIC ANALYSES OF AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROMEZ01AI000732 · NIAID · NIAID EXTRAMURAL ACTIVITIES · PI RAO, VEMULKONDA · 1995 to 2008
$1.1MAbstract
backgroundBladder cancer mortality rates have been elevated in northern New England for at least five decades. Incidence rates in Maine, New Hampshire, and Vermont are about 20% higher than the United States overall. We explored reasons for this excess, focusing on arsenic in drinking water from private wells, which are particularly prevalent in the region.
methodsIn a population-based case-control study in these three states, 1213 bladder cancer case patients and 1418 control subjects provided information on suspected risk factors. Log transformed arsenic concentrations were estimated by linear regression based on measurements in water samples from current and past homes. All statistical tests were two-sided.
resultsBladder cancer risk increased with increasing water intake (Ptrend = .003). This trend was statistically significant among participants with a history of private well use (Ptrend = .01). Among private well users, this trend was apparent if well water was derived exclusively from shallow dug wells (which are vulnerable to contamination from manmade sources, Ptrend = .002) but not if well water was supplied only by deeper drilled wells (Ptrend = .48). If dug wells were used pre-1960, when arsenical pesticides were widely used in the region, heavier water consumers (>2.2 L/day) had double the risk of light users (<1.1 L/day, Ptrend = .01). Among all participants, cumulative arsenic exposure from all water sources, lagged 40 years, yielded a positive risk gradient (Ptrend = .004); among the highest-exposed participants (97.5th percentile), risk was twice that of the lowest-exposure quartile (odds ratio = 2.24, 95% confidence interval = 1.29 to 3.89).
conclusionsOur findings support an association between low-to-moderate levels of arsenic in drinking water and bladder cancer risk in New England. In addition, historical consumption of water from private wells, particularly dug wells in an era when arsenical pesticides were widely used, was associated with increased bladder cancer risk and may have contributed to the New England excess.
Indexed as
AdultAgedArsenicCase-Control StudiesDrinkingDrinking WaterFemaleHumansIncidenceMaineMaleMiddle AgedNew HampshireRisk FactorsUnited StatesUrinary Bladder NeoplasmsArsenicDrinking Water
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