ArticleProceedings of the National Academy of Sciences of the United States of America2016
Living biofouling-resistant membranes as a model for the beneficial use of engineered biofilms.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 73 citations in OpenAlex.
- Current Trends and Biotechnological Innovations in Biofouling Control of RO Membranes in Desalination Systems.Membranes · 2025Review
- Engineered Marine Biofilms for Ocean Environment Monitoring.ACS synthetic biology · 2025Article
- Strength in diversity: unlocking the full potential of engineered living materials with multistrain collaboration.FEMS microbiology reviews · 2025Review
- Optogenetic patterning generates multi-strain biofilms with spatially distributed antibiotic resistance.Nature communications · 2024Article
- Biomimetic Wearable Sensors: Emerging Combination of Intelligence and Electronics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Energy and nutrient recovery from municipal and industrial waste and wastewater-a perspective.Journal of industrial microbiology & biotechnology · 2024Review
- Nitric oxide-secreting probiotics as sustainable bio-cleaners for reverse osmosis membrane systems.Environmental science and pollution research international · 2022Review
- Article
- Engineering controllable biofilms for biotechnological applications.Microbial biotechnology · 2021Article
- Review
- Surface waves control bacterial attachment and formation of biofilms in thin layers.Science advances · 2020Article
- Coral Reef Microorganisms in a Changing Climate.iScience · 2020Review
- Importance of the biofilm matrix for the erosion stability ofRSC advances · 2019Article
- Editorial: Quorum Network (Sensing/Quenching) in Multidrug-Resistant Pathogens.Frontiers in cellular and infection microbiology · 2019Article
- Regulating exopolysaccharide gene wcaF allows control of Escherichia coli biofilm formation.Scientific reports · 2018Article
- Review
- Engineered Living Materials: Prospects and Challenges for Using Biological Systems to Direct the Assembly of Smart Materials.Advanced materials (Deerfield Beach, Fla.) · 2018Review
- Biofilm Lithography enables high-resolution cell patterning via optogenetic adhesin expression.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Membrane Bioreactor (MBR) Technology for Wastewater Treatment and Reclamation: Membrane Fouling.Membranes · 2016Review
- Controlling biofilms using synthetic biology approaches.Biotechnology advancesReview
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Membrane systems are used increasingly for water treatment, recycling water from wastewater, during food processing, and energy production. They thus are a key technology to ensure water, energy, and food sustainability. However, biofouling, the build-up of microbes and their polymeric matrix, clogs these systems and reduces their efficiency. Realizing that a microbial film is inevitable, we engineered a beneficial biofilm that prevents membrane biofouling, limiting its own thickness by sensing the number of its cells that are present via a quorum-sensing circuit. The beneficial biofilm also prevents biofilm formation by deleterious bacteria by secreting nitric oxide, a general biofilm dispersal agent, as demonstrated by both short-term dead-end filtration and long-term cross-flow filtration tests. In addition, the beneficial biofilm was engineered to produce an epoxide hydrolase so that it efficiently removes the environmental pollutant epichlorohydrin. Thus, we have created a living biofouling-resistant membrane system that simultaneously reduces biofouling and provides a platform for biodegradation of persistent organic pollutants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.