ArticleProceedings of the National Academy of Sciences of the United States of America2016
Dopamine pathway is highly diverged in primate species that differ markedly in social behavior.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 40 citations in OpenAlex.
- Distribution of Serotonergic Transporter Innervation in the Nucleus Accumbens and Ventral Pallidum Is Highly Conserved Among Primates.The Journal of comparative neurology · 2025Article
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- Neuroendocrine mechanisms contributing to the coevolution of sociality and communication.Frontiers in neuroendocrinology · 2023Review
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- Genomic signatures of high-altitude adaptation and chromosomal polymorphism in geladas.Nature ecology & evolution · 2022Article
- The nucleus accumbens and ventral pallidum exhibit greater dopaminergic innervation in humans compared to other primates.Brain structure & function · 2021Article
- Comparative analysis reveals distinctive epigenetic features of the human cerebellum.PLoS genetics · 2021Article
- The 4 D's of Pellagra and Progress.International journal of tryptophan research : IJTR · 2020Review
- Human-specific mutations in VMAT1 confer functional changes and multi-directional evolution in the regulation of monoamine circuits.BMC evolutionary biology · 2019Article
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- Evolution of DNA Methylation in Papio Baboons.Molecular biology and evolution · 2019Article
- Nicotinamide as Independent Variable for Intelligence, Fertility, and Health: Origin of Human Creative Explosions?International journal of tryptophan research : IJTR · 2019Review
- The comparative genomics and complex population history ofScience advances · 2019Article
- Non-invasive genotyping with a massively parallel sequencing panel for the detection of SNPs in HPA-axis genes.Scientific reports · 2018Article
- A neurochemical hypothesis for the origin of hominids.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Tetrahydrobiopterin regulates monoamine neurotransmitter sulfonation.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Genes, dopamine pathways, and sociality in primates.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
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4 authors at 3 institutions in 1 country.
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Abstract
In the endeavor to associate genetic variation with complex traits, closely related taxa are particularly fruitful for understanding the neurophysiological and genetic underpinnings of species-specific attributes. Similarity to humans has motivated research into nonhuman primate models, yet few studies of wild primates have investigated immediate causal factors of evolutionarily diverged social behaviors. Neurotransmitter differences have been invoked to explain the distinct behavioral suites of two baboon species in Awash, Ethiopia, which differ markedly in social behavior despite evolutionary propinquity. With this natural experiment, we test the hypothesis that genomic regions associated with monoamine neurotransmitters would be highly differentiated, and we identify a dopamine pathway as an outlier, highlighting the system as a potential cause of species-specific social behaviors. Dopamine levels and resultant variation in impulsivity were likely under differential selection in the species due to social system structure differences, with either brash or circumspect social behavior advantageous to secure mating opportunities depending on the social backdrop. Such comparative studies into the causes of the behavioral agendas that create and interact with social systems are of particular interest, and differences in temperament related to boldness and associated with dopamine variation likely played important roles in the evolution of all social, behaviorally complex animals, including baboons and humans.
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