Evidence map›Paper›PMID 27140518›Full record

ArticleTransplantation2017

Outcomes of Solid Organ Transplants After Simultaneous Solid Organ and Vascularized Composite Allograft Procurements: A Nationwide Analysis.

Mario A Aycart, Muayyad Alhefzi, Gaurav Sharma, Nicco Krezdorn, Ericka M Bueno, Simon G Talbot, Matthew J Carty, Stefan G Tullius, Bohdan Pomahac

Abstract read
In one paragraph

Article in Transplantation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mario A Aycart1 Division of Plastic Surgery, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA. 2 Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA. 3 Division of Transplant Surgery, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Muayyad Alhefzi
Gaurav Sharma
Nicco Krezdorn
Ericka M Bueno
Simon G Talbot
Matthew J Carty
Stefan G Tullius
Bohdan Pomahac

Funding

ADVANCED TRAINING IN SURGICAL ONCOLOGYT32CA009535 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BUENO, RAPHAEL · 1985 to 2015
$3.5M
Consequences of Aging on Immune Response and Transplant OutcomeR01AG039449 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI TULLIUS, STEFAN GUNTHER · 2012 to 2016
$1.6M
NCI NIH HHS T32 CA009535NIA NIH HHS R01 AG039449
6 · The paper itself

Abstract

backgroundCurrent knowledge of the impact of facial vascularized composite allograft (VCA) procurement on the transplantation outcomes of the concomitantly recovered solid organs is limited to isolated case reports and short-term results. Here we report on a nationwide analysis of facial allograft donor surgery experience and long-term outcomes of the concomitantly recovered solid organs and their recipients.

methodsThere were 10 facial VCA procurements in organ donors between December 2008 and October 2014. We identified the population of subjects who received solid organs from these 10 donors using the Scientific Registry of Transplant Recipients. We retrospectively reviewed operative characteristics, intraoperative parameters, and postoperative outcomes.

resultsSix of 10 donor surgeries were performed at outside institutions, all on brain-dead donors. Mean operative duration for facial VCA recovery was 6.9 hours (range, 4-13.25 hours). A total of 36 solid organs were recovered and transplanted into 35 recipients. Survival rates for kidney and liver recipients were 100% and 90% at a median follow-up of 33 and 27.5 months, respectively (range, 6-72 months). Graft survival rates for kidneys and livers were 15 of 16 (94%) and 9 of 10 (90%), respectively. Recipient and graft survival rates for hearts and lungs were 75% (n = 4) and 100% (n = 3) at mean follow-up time of 14.75 and 16 months, respectively. A liver recipient died at 22 months from unknown causes and a heart recipient died of leukemia at 10 months.

conclusionsFacial VCA procurement does not appear to adversely affect the outcomes of transplant recipients of concomitantly recovered solid organ allografts.

Indexed as

Composite Tissue AllograftsGraft SurvivalTissue DonorsAdultFacial TransplantationFemaleHumansMaleMiddle AgedOperative TimeOrgan TransplantationPostoperative ComplicationsRegistriesRetrospective StudiesRisk AssessmentRisk Factors

Identifiers

PMID27140518
PMCPMC6347371

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.