Evidence map›Paper›PMID 27140407›Full record

ArticleImmunotherapy2016

Adoptive transfer of aminobisphonate-expanded Vγ9Vδ2+ T cells does not control HIV replication in a humanized mouse model.

Bhawna Poonia

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunotherapy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Bhawna PooniaInstitute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, USA.
University of Maryland, Baltimore · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimVγ9Vδ2 γδ T cells have effector potential against several cancers and infectious agents. Whether these cells control HIV replication was tested in humanized mouse model.

methodsNOD SCID gamma mice engrafted with human peripheral blood mononuclear cells (PBMCs) and infected with HIVBAL were treated with zoledronate-expanded Vγ9Vδ2 T cells either alone or in combination with an anti-HIV envelope antibody b12.

resultsSevere depletion of CD4+CCR5+ T cells was observed in PBMCs of all infected mice. HIV plasma p24 levels were comparable in all infected groups with no decrease in plasma viremia achieved by adoptive transfer of cells.

conclusionAutologous transfer of ex vivo expanded Vγ9Vδ2 T cells may not be a successful treatment choice for controlling HIV replication in vivo.

Indexed as

Adoptive TransferAnimalsAntibodies, MonoclonalCD4-Positive T-LymphocytesCell ProliferationDiphosphonatesDisease Models, AnimalHIV-1HIV Core Protein p24HIV Envelope Protein gp120HIV InfectionsHumansImidazolesMiceMice, Inbred NODMice, SCIDAntibodies, MonoclonalCCR5 protein, mouseDiphosphonatesHIV Core Protein p24HIV Envelope Protein gp120Imidazolesp24 protein, Human Immunodeficiency Virus Type 1Receptors, Antigen, T-Cell, gamma-deltaReceptors, CCR5T-cell receptor Vdelta2, humanT-cell receptor Vgamma9, humanZoledronic Acidgamma deltaHIVhumanized mouseVγ9Vδ2

Identifiers

PMID27140407
PMCPMC5705801
OpenAlexW2346155464

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.