Evidence map›Paper›PMID 27140337›Full record

SynthesisInternational journal of cardiology2016

64 slice-coronary computed tomography sensitivity and specificity in the evaluation of coronary artery bypass graft stenosis: A meta-analysis.

Umberto Barbero, Mario Iannaccone, Fabrizio d'Ascenzo, Cristina Barbero, Abdirashid Mohamed, Umberto Annone, Sara Benedetto, Dario Celentani, Marco Gagliardi, Claudio Moretti and 1 more

Registry-linked trialAbstract readComparative StudyMeta-AnalysisReview
PubMed Publisher
In one paragraph

Synthesis in International journal of cardiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03265041 (Predictors of Long Term Graft Patency After Coronary Artery Bypass Graft Surgery), which is not on this map. Cited by 35 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03265041 completednot on this mapstarted 2018, after this paper: background citation

Predictors of Long Term Graft Patency After Coronary Artery Bypass Graft Surgery (Multi-slice CT Coronary Angiography Study Validated by Coronary Angiography)

TypeobservationalSponsorAssiut UniversityRan2018 to 2020Enrolled40ConditionsCoronary Artery DiseaseArmsmulti-slice CT coronary angiography and coronary angiography
3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  6. Guideline for Chronic Coronary Syndrome - 2025.Arquivos brasileiros de cardiologia · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Umberto BarberoCardiology Department, Città Della Salute e della Scienza Hospital, Turin, Italy. Electronic address: u.barbero@gmail.com.
Mario IannacconeCardiology Department, Città Della Salute e della Scienza Hospital, Turin, Italy.
Fabrizio d'AscenzoCardiology Department, Città Della Salute e della Scienza Hospital, Turin, Italy.
Cristina BarberoCardiac Surgery Department, Città Della Salute e della Scienza Hospital, Turin, Italy.
Abdirashid MohamedCardiology Department, Città Della Salute e della Scienza Hospital, Turin, Italy.
Umberto AnnoneCardiology Department, Città Della Salute e della Scienza Hospital, Turin, Italy.
Sara BenedettoCardiology Department, Città Della Salute e della Scienza Hospital, Turin, Italy.
Dario CelentaniCardiology Department, Città Della Salute e della Scienza Hospital, Turin, Italy.
Marco GagliardiCardiology Department, Città Della Salute e della Scienza Hospital, Turin, Italy.
Claudio MorettiCardiology Department, Città Della Salute e della Scienza Hospital, Turin, Italy.
Fiorenzo GaitaCardiology Department, Città Della Salute e della Scienza Hospital, Turin, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A non-invasive approach to define grafts patency and stenosis in the follow-up of coronary artery bypass graft (CABG) patients may be an interesting alternative to coronary angiography. 64-slice-coronary computed tomography is nowadays a diffused non-invasive method that permits an accurate evaluation of coronary stenosis, due to a high temporal and spatial resolution. However, its sensitivity and specificity in CABG evaluation has to be clearly defined, since published studies used different protocols and scanners. We collected all studies investigating patients with stable symptoms and previous CABG and reporting the comparison between diagnostic performances of invasive coronary angiography and 64-slice-coronary computed tomography. As a result, sensitivity and specificity of 64-slice-coronary computed tomography for CABG occlusion were 0.99 (95% CI 0.97-1.00) and 0.99 (95% CI: 0.99-1.00) with an area under the curve (AUC) of 0.99. 64-slice-coronary computed tomography sensitivity and specificity for the presence of any CABG stenosis >50% were 0.98 (95% CI: 0.97-0.99) and 0.98 (95% CI: 0.96-0.98), while AUC was 0.99. At meta-regression, neither the age nor the time from graft implantation had effect on sensitivity and specificity of 64-slice-coronary computed tomography detection of significant CABG stenosis or occlusion. In conclusion 64-slice-coronary computed tomography confirmed its high sensitivity and specificity in CABG stenosis or occlusion evaluation.

Indexed as

Area Under CurveCoronary AngiographyCoronary Artery BypassCoronary StenosisFemaleHumansMaleSensitivity and SpecificityTomography, X-Ray ComputedCoronary artery by-pass graftCoronary artery diseaseCoronary artery stenosisCoronary computed tomography

Identifiers

PMID27140337

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.