ArticleThe Journal of experimental medicine2016
Recent thymic emigrants are tolerized in the absence of inflammation.
Article in The Journal of experimental medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 42 citations in OpenAlex.
- Neonatal liver niches program T cell tolerance.bioRxiv : the preprint server for biology · 2026Article
- Measuring thymic output across the human lifespan: a critical challenge in laboratory medicine.GeroScience · 2025Review
- Lung injury induces a polarized immune response by self-antigen-specific CD4Cell reports · 2023Article
- Programmed and environmental determinants driving neonatal mucosal immune development.Immunity · 2023Review
- From thymus to tissues and tumors: A review of T-cell biology.The Journal of allergy and clinical immunology · 2023Review
- The adaptive immune system in early life: The shift makes it count.Frontiers in immunology · 2022Review
- Naïve Regulatory T Cell Subset Is Altered in X-Linked Agammaglobulinemia.Frontiers in immunology · 2021Article
- Tolerization of recent thymic emigrants is required to prevent RBC-specific autoimmunity.Journal of autoimmunity · 2020Article
- Building a T cell compartment: how immune cell development shapes function.Nature reviews. Immunology · 2020Review
- Control of PersistentPathogens (Basel, Switzerland) · 2020Article
- Developmental and cellular age direct conversion of CD4+ T cells into RORγ+ or Helios+ colon Treg cells.The Journal of experimental medicine · 2020Article
- The Plasticity of Newly Formed B Cells.Journal of immunology (Baltimore, Md. : 1950) · 2019Review
- Dissecting the defects in the neonatal CD8Journal of leukocyte biology · 2019Review
- Peripheral blood CD4+ T cell populations by CD25 and Foxp3 expression as a potential biomarker: reflecting inflammatory activity in chronic obstructive pulmonary disease.International journal of chronic obstructive pulmonary disease · 2019Article
- Predicting therapeutic response to fingolimod treatment in multiple sclerosis patients.CNS neuroscience & therapeutics · 2018Article
- Cutting Edge: Glycolytic Metabolism and Mitochondrial Metabolism Are Uncoupled in Antigen-Activated CD8Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Testosterone Protects Against Atherosclerosis in Male Mice by Targeting Thymic Epithelial Cells-Brief Report.Arteriosclerosis, thrombosis, and vascular biology · 2018Article
- The full spectrum of human naive T cells.Nature reviews. Immunology · 2018Review
- Reinterpreting recent thymic emigrant function: defective or adaptive?Current opinion in immunology · 2018Review
- Generation of Tumor Antigen-Specific iPSC-Derived Thymic Emigrants Using a 3D Thymic Culture System.Cell reports · 2018Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
T cell development requires a period of postthymic maturation. Why this is the case has remained a mystery, particularly given the rigors of intrathymic developmental checkpoints, successfully traversed by only ∼5% of thymocytes. We now show that the first few weeks of T cell residence in the lymphoid periphery define a period of heightened susceptibility to tolerance induction to tissue-restricted antigens (TRAs), the outcome of which depends on the context in which recent thymic emigrants (RTEs) encounter antigen. After encounter with TRAs in the absence of inflammation, RTEs exhibited defects in proliferation, diminished cytokine production, elevated expression of anergy-associated genes, and diminished diabetogenicity. These properties were mirrored in vitro by enhanced RTE susceptibility to regulatory T cell-mediated suppression. In the presence of inflammation, RTEs and mature T cells were, in contrast, equally capable of inducing diabetes, proliferating, and producing cytokines. Thus, recirculating RTEs encounter TRAs during a transitional developmental stage that facilitates tolerance induction, but inflammation converts antigen-exposed, tolerance-prone RTEs into competent effector cells.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.