ArticleAntimicrobial agents and chemotherapy2016
Previous Antibiotic Exposure Increases Risk of Infection with Extended-Spectrum-β-Lactamase- and AmpC-Producing Escherichia coli and Klebsiella pneumoniae in Pediatric Patients.
Article in Antimicrobial agents and chemotherapy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 51 citations in OpenAlex.
- Two-Year Outcomes of Postoperative Spine Infection: Implant Retention and Predictors of Treatment Failure.Open forum infectious diseases · 2026Article
- New perspectives on extracorporeal life support: expert teams and precise selection of candidates are transforming pediatric cancer and hematopoietic cell transplantation care.Frontiers in oncology · 2025Article
- Comparison of Outcomes in Neonates Receiving Cefepime or Ceftazidime.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2023Article
- Pathogenicity Islands in UropathogenicAntibiotics (Basel, Switzerland) · 2022Article
- Carbapenem-Resistant Organisms Isolated in Surgical Site Infections in Benin: A Public Health Problem.Tropical medicine and infectious disease · 2022Article
- Management of Pediatric Urinary Tract Infections: A Delphi Study.Antibiotics (Basel, Switzerland) · 2022Article
- Treatment and Epidemiology of Third-Generation Cephalosporin-Resistant Urinary Tract Infections.Pediatrics · 2022Article
- Antibiotic exposure and acquisition of antibiotic-resistant gram-negative bacteria among outpatients at a US Veterans Affairs medical center.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2022Article
- Risk of Multidrug Resistant Bacteria Acquisition in Patients with DeclaredJournal of immunology research · 2022Article
- Retrospective 8-Year Study on the Antibiotic Resistance of Uropathogens in Children Hospitalised for Urinary Tract Infection in the Emilia-Romagna Region, Italy.Antibiotics (Basel, Switzerland) · 2021Article
- Novel chromosomal insertions of ISEcp1-blaAntimicrobial resistance and infection control · 2021Article
- Antibiotic Resistance in Pediatric Infections: Global Emerging Threats, Predicting the Near Future.Antibiotics (Basel, Switzerland) · 2021Review
- Whole Genome Sequencing Detects Minimal Clustering Among Escherichia coli Sequence Type 131-H30 Isolates Collected From United States Children's Hospitals.Journal of the Pediatric Infectious Diseases Society · 2021Article
- Prior Antibiotic Therapy and the Onset of Healthcare-Associated Infections Sustained by Multidrug-ResistantAntibiotics (Basel, Switzerland) · 2021Article
- Prevalence, serotyping and drug susceptibility patterns ofWorld journal of biological chemistry · 2020Article
- Multidrug-resistant organisms in urinary tract infections in children.Pediatric nephrology (Berlin, Germany) · 2020Review
- A Decision Tree Using Patient Characteristics to Predict Resistance to Commonly Used Broad-Spectrum Antibiotics in Children With Gram-Negative Bloodstream Infections.Journal of the Pediatric Infectious Diseases Society · 2020Article
- A Clinical Prediction Scoring System for Cephalosporin Resistance Among Enteric Uropathogens: Indications and Practicality.Open forum infectious diseases · 2019Article
- Influence of antibiotic pressure on multi-drug resistantAntimicrobial resistance and infection control · 2019Observational
- Efficacy of a Postprescription Review of Broad-Spectrum Antimicrobial Agents With Feedback: A 4-Year Experience of Antimicrobial Stewardship at a Tertiary Care Center.Open forum infectious diseases · 2018Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
Abstract
The objective of this study was to determine whether antibiotic exposure is associated with extended-spectrum-beta-lactamase- or AmpC-producing Escherichia coli or Klebsiella pneumoniae infections in children. We collected extended-spectrum-beta-lactamase- or AmpC-producing E. coli or K. pneumoniae isolates and same-species susceptible controls from normally sterile sites of patients aged ≤21 years, along with associated clinical data, at four free-standing pediatric centers. After controlling for potential confounders, the relative risk of having an extended-spectrum-beta-lactamase-producing isolate rather than a susceptible isolate was 2.2 times higher (95% confidence interval [CI], 1.49 to 3.35) among those with antibiotic exposure in the 30 days prior to infection than in those with no antibiotic exposure. The results were similar when analyses were limited to exposure to third-generation cephalosporins, other broad-spectrum beta-lactams, or trimethoprim-sulfamethoxazole. Conversely, the relative risk of having an AmpC-producing versus a susceptible isolate was not significantly elevated with any antibiotic exposure in the 30 days prior to infection (adjusted relative risk ratio, 1.12; 95% CI, 0.65 to 1.91). However, when examining subgroups of antibiotics, the relative risk of having an AmpC-producing isolate was higher for patients with exposure to third-generation cephalosporins (adjusted relative risk ratio, 4.48; 95% CI, 1.75 to 11.43). Dose-response relationships between antibiotic exposure and extended-spectrum-beta-lactamase-producing or AmpC-producing isolates were not demonstrated. These results reinforce the need to study and implement pediatric antimicrobial stewardship strategies, and they indicate that epidemiological studies of third-generation cephalosporin-resistant E. coli and K. pneumoniae isolates should include resistance mechanisms when possible.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.